Dwi Setyawan

Identification of Physical Interaction in Binary Systems of Acyclovir – Succinic Acid

Background: Acyclovir, a guanosine analogue antiviral drug with low solubility of water. Due to its poor solubility and permeability, causes low oral bioavailability. Objective: The aim of this research is to investigate the physical interaction in binary systems acyclovir-succinic acid (AS). Methods: The msystem was prepared by solvent evaporation method. Results: Thermogram Differential Scanning Calorimetry showed endothermic peaks at 172.68oC (ethanol) and 171.84oC (methanol). The Powder X-Ray Diffraction (PXRD) pattern of AS was different from pure component and physical mixtures. Furthermore, physical characterization showed the binary system of AS have unique crystal habit by polarization microscope. Conclusion: New crystalline phase is formed from the interaction between acyclovir and succinic acid by solvent evaporation method using ethanol and methanol.

Solid State Characterization of Acyclovir-Nicotinamide Binary Systems using Solvent Evaporation Technique

Objective of the study is to characterize acyclovir-nicotinamide binary systems (AN). Methods ofcocrystallization wassolvent evaporation in equimolar ratio between acyclovir and nicotinamide using ethanoland methanol. The binary systems were characterized by polarization microscope, Differential ScanningCalorimetry (DSC) and Powder X-Ray Diffraction (PXRD). Physical characterization showed that AN binarysystems have unique crystal habit in microscopic. A new endothermic peak appears at 123.69 C. The PXRDpatterns of AN binary systems after cocrystallization are different from pure components which specific peakwasfound on 2θ = 11.27 o (AN in ethanol); 21.05 o (AN in methanol).