E. A. Rovenstine

Protecting Action of Chemicals Related to Procaine on Ventricular Fibrillation During Cyclopropane Anesthesia

Conclusions The administration of p-amino benzoic acid, the calcium double salt of benzyl succinic and p-amino benzoic acids, or sodium p-amino benzoate prior to a test dose of epinephrine during cyclopropane anesthesia reduced the incidence of ventricular fibrillation. The intracardiac injection of procaine at the time when ventricular fibrillation developed effected a return to normal in a number of cases. Ventricular fibrillation was not ameliorated by the intracardiac injection of the other three p-amino benzoic acid derivatives. The authors wish to express their appreciation for the helpful suggestions of Dr. Arthur C. DeGraff.

Ghromodacryorrhea and Parasympathetic Action of Cyclopropane

Summary The phenomenon of chromodacryorrhea produced by cyclopropane in eserinized white rats indicates that acetylcholine is liberated in mammalian tissues and supports the contention that the drug is a parasympathetic stimulant.

Effects of Spinal Anesthesia upon Venous Pressure in Man

Summary A decrease of venous pressure follows spinal anesthesia accompanied by intercostal paralyses irrespective of arterial pressure changes. A further decrease accompanies a fall of arterial pressure. No consistent changes accompanied low spinal anesthesia.

Influence of Anesthesia on Circulatory Changes in Dogs Subjected to Graded Hemorrhage.

Summary and Conclusions 1. Circulatory responses to graded hemorrhage varied significantly with six anesthetic procedures studied. 2. Of the drugs studied with the criteria used, the changes with cyclopropane most nearly approached those observed in animals receiving only local procaine. 3. The effects of anesthetic drugs must be taken into consideration in evaluating experimental shock studies.

Toxicity of Intravenous Paraldehyde

Conclusions The intravenous administration of paraldehyde as recommended for clinical anesthesia is not without danger. In experimental animals there is a narrow margin of safety (Minimum Anesthetic Dose-Minimum Lethal Dose). Massive diffuse pulmonary hemorrhages and dilatation of the right heart occur when animals are killed with minimum lethal doses. Pulmonary hemorrhages are present in animals having recovered from anesthetic doses.

Circulatory Effects from Cyclopropane Administered After Hemorrhage.

Conclusion Preliminary observations seem to substantiate the clinical impression that cyclopropane is a useful anesthetic agent in the presence of circulatory depression due to rapid hemorrhage.