E. A. Yakovenko

Syndrome of autonomic dysfunction in children and adolescents

AIM To study clinical and pathophysiological symptoms of autonomic dysfunction syndrome in children and adolescents and assess the efficacy of its treatment with nooclerin. MATERIAL AND METHODS Fifty-three patients, aged from 10 to 15 years, with autonomic dysfunction syndrome were examined. All patients underwent neurological examination, assessment with the A.M. Veins questionnaire of autonomic disorders, the 10 point Visual Analogous scale for headache and fatigue, the Spielberger-Khanin scale for anxiety, Kerdo index, Hildebrandts coefficient, electrocardiography with clinoorthostatic test, electroencephalography, and TOVA psychophysiological test. RESULTS AND CONCLUSION The signs of the asthenic-autonomic syndrome were characteristic of the clinical picture of disease. EEG results demonstrated the deficit of activation effects, predominance of synchronized effects of thalamic structures which led to the insufficient activation of cortical structures. These data support the high efficacy of nooclerin.

Последствия специфических расстройств речевого развития у детей

AIM To assess cognitive and emotional disorders in children of primary school age who have a history of specific language impairment (SLI). MATERIAL AND METHODS Eighty-six children, aged 7-9 years, who were previously studied at age of 3-6 years with a diagnosis of SLI with a predominant disorder of expressive speech, were examined. Common neurological examination, psychological and psychometric testing were performed. RESULTS AND CONCLUSION Clinical manifestations of the developmental disorder of expressive speech of moderate degree remained in 19.8% of children. In 53.4% of cases, the state of children could be regarded as an organic asthenic disorder. Clinical manifestations of Attention Deficit Hyperactivity Disorder (ADHD) were observed in 24.4% of children. Disorders of the formation of school skills were revealed in 32.5% of children. Thus, the SLI play an important role in the formation of cognitive, emotional and regulatory disorders and can serve as predictors of the development of other neuropsychiatric diseases.

Исследование эффективности цитофлавина в лечении соматоформных расстройств

AIM To study the efficacy of cytoflavin in patients with somatoform disorders (SD). MATERIAL AND METHODS The study included 60 patients with SD, aged from 27 to 43 years. The efficacy was assessed by the results of psychological and neurophysiological examinations. RESULTS AND CONCLUSION The higher efficacy of cytoflavin (the improvement of patients condition in 63,3% of cases) compared to that of ethylmethylhydroxypyridine succinate (56,7% of cases) was found. Patients state was more stable after treatment with cytoflavin.

Сlinical and physiological characteristics and therapy asthenic disorders in adolescents girls

AIM To study clinical and psychophysiological characteristics of asthenic disorders in adolescent girls in the aspect of treatment efficacy of cortexin. MATERIAL AND METHODS Seventy-five women, aged 14-17 years, who were diagnosed with neurasthenia (ICD-10 F.48.0), were examined. Conventional neurological examination, a 10-point Visual Analogue Scale, the Multidimensional Fatigue Inventory (MFI-20), the A.M. Vein questionnaire, the Spielberger-Khanin questionnaire and EEG were used. RESULTS AND CONCLUSION The high level of anxiety resulted in the development of autonomic symptoms and cephalgia. The EEG study showed that women with neurasthenia were characterized by lower alpha-rhythm power in the occipital sites compared with healthy peers. Treatment with cortexin improved patients condition in 80% of cases that was supported by the positive EG dynamics.

Diagnosis and treatment of cognitive impairment in adults with attention deficit hyperactivity disorder

AIM To qualify cognitive impairment in adults with attention deficit hyperactivity disorder (ADHD) and evaluate the efficacy of memoplant in the treatment of this pathology. MATERIAL AND METHODS The authors present the results of the clinical, psychological and electroencephalographic examination of 40 patients with ADHD, aged from 18 to 45 years. All patients received memoplant in dose of 240 mg a day for 8 weeks. RESULTS AND CONCLUSION Adult patients with ADHD were characterized by both subjective and objective disorders of memory and attention. The results of the electroencephalographic study suggested the dysfunction of the frontal-thalamic regulatory system and the lack of non-specific activation of the reticular formation. After treatment, clinical improvement was observed in 24 patients (60.0%). Repeated psychological and neuropsychological examinations showed a reduction of inattention and improvement of memory performance.

Emotional impairments and their correction in patients with migraine

AIM To study emotional impairments in patients with migraine and to evaluate the efficiency of Noophen therapy for this pathology. SUBJECTS AND METHODS 63 patients aged 18 to 45 years with migraine without aura were examined. 56 patients used prophylactic antimigraine therapy: Group 1 (n = 26) received metoprolol and Group 2 took metoprolol in combination with Noophen. RESULTS The patients with migraine had a significantly higher level of alexithymia than the controls. Concomitant anxiety disorders were found in 47 (74.6%) cases. The study provided evidence that the treatment was highly effective in Group 2 that exhibited a more pronounced decrease in pain intensity, a greater reduction in the levels of anxiety, and more vital activity. CONCLUSION The results of this study allow a conclusion that emotional impairments are implicated in the pathogenesis and clinical presentations of migraine and that it is appropriate to use Noophen for the treatment of this pathology.

Clinical and neurophysiological heterogeneity of attention deficit hyperactivity disorder

AIM To determine clinical/neurophysiological characteristics of different forms of attention deficit hyperactivity disorder (ADHD) and the efficacy of treatment with cerebrolysin. MATERIAL AND METHODS Sixty children, aged 9 to 12 years, with ADHD were examined using clinical and electroencephalographic methods. Idiopathic and residual-organic forms were compared. RESULTS AND CONCLUSION The study shows significantly higher levels of impulsivity and hyperactivity in children with residual-organic form of the disease. There were significant differences in the amplitude component of engaging in action (P3 Go) and the amplitude of the action suppression component (P3 NOGO) in patients with different forms of ADHD. The high clinical efficacy (improvement in 70.0% of patients with idiopathic form of ADHD and 86.7% of patients with residual-organic form of the disease) was found.

Efficacy of Cortexin in the Treatment of Memory Disorders in Children

Children aged 7–12 years with memory disorders were treated with Cortexin (30 patients) or Encephabol (30 patients). A comparative study of the efficacy and safety of each of these agents was conducted. Cortexin was found to have greater efficacy (improvements in 86.7% of cases) than Encephabol (improvements in 63.3% of cases), supported by neuropsychological and neurophysiological results.

Неврастения: состояние проблемы и подходы к терапии

Objective: to study the efficacy of metaprot in the treatment of neurasthenia. Patients and methods. Thirty patients aged 18 to 45 years with neurasthenia (F48.0) were followed up. The patients were examined using a subjective asthenia rating scale (Multidimensional Fatigue Inventory (MFI-20)), a 10-point anesthesia visual analog scale, Spielberger’s self-report scale modified by Yu.L. Khanin, and a computed Test of Variables of Attention (TOVA). Metaprot was given in a dose of 0.25 g b.i.d. after morning and evening meals as two administrations for 10 days (5 days at a 2-day interval). The results of therapy were assessed on day 30 after its course. Results. There was clinical improvement in 21 (70.0%) patients after metaprot therapy. Evaluation of the patient’s status using the MFI-20 showed a significant improvement in the items of general asthenia, physical asthenia, psychic asthenia, and decreased activity. Psychophysiological examination using the TOVA revealed a significant reduction in response times, as compared to the scores obtained before the treatment, and a decrease in the number of errors in the second half of the test, which allows us to state that there is a reduction in the degree of mental exhaustion and an increase in work capacity after the treatment. Psychological tests showed no significant reduction in anxiety scores. There were no adverse reactions or complications. It has been concluded that it is promising to use metaprot to treat neurasthenia.