E.Brown Robbins

Toxicity of Nicotinic Acid

Summary Nicotinic acid is at least several hundred times less toxic in mice, rats, and guinea pigs than nicotine. Nicotinic acid is devoid of action upon the autonomic ganglia. Nevertheless, repeated administration of large doses, 2 gm. daily, in dogs has resulted in poisoning and deaths.

K-Strophanthin-β, K-Strophanthoside, Periplocymarin, and Periplocin

Summary K-Strophanthin-β is more potent than K-strophanthoside in frogs and cats, while periplocymarin is less potent than periplocin. The decrease in the number of sugar molecules of a cardiac glycoside, therefore, may or may not be accompanied by an increase in activity.