E. F. Panarin

Water-soluble polymer derivatives of cholesterol

New cholesterol-containing water-soluble polymers based on N-methacryloyl aminoglucose and N-vinylpyrrolidone are synthesized by free-radical copolymerization and polymer-analogous transformations. Binary and ternary copolymers of various composition containing N-allylamine and N,N,N-trimethylaminoethyl methacrylate methyl sulfate units and cholesterol residues are prepared. Luminescently labeled copolymers of the same composition are obtained. Effects of the nature of polymers and the amount of cholesterol in them on the intramolecular mobility of macromolecules in solution are studied with polarized luminescence. When 2–4 mol % of cholesterol residues are incorporated into the copolymer, the intramolecular mobility of macromolecules decreases, thus indicating formation of intramolecular compact structures via interaction of nonpolar cholesterol groups. In copolymers containing charged groups, these structures are looser than those in neutral copolymers. It is shown that macromolecules of cholesterol-containing polymers of various types can interact with each other. 1 This work was supported by the Russian Foundation for Basic Research (project no. 08-03-00324) and the Council for Grants of the President of the Russian Federation for Support of Leading Institutes of Higher Education (NSh-4391.2008.3).

Copolymers of 2-deoxy-2-methacrylamido-D-glucose and unsaturated acids

New copolymers of the vinyl saccharide 2-deoxy-2-methacrylamido-D-glucose (M1) with acrylic and methacrylic (M2) acids differing in composition and molecular mass have been synthesized by free-radical copolymerization. The relative activities of the comonomers are determined. It is found that, for acrylic acid, r 1 = 3.03 ± 0.15 and r 2 = 0.5 ± 0.08 and, for methacrylic acid, r 1 = 1.070 ± 0.1 and r 2 = 1.18 ± 0.13. As is evidenced by potentiometric and viscometric measurements, the vinyl saccharide and acid units are capable of interacting, a circumstance that affects the conformational states of macromolecules.

Characteristics of Aqueous Solutions of Methyl Cellulose-Polymethacrylamidoglucose Mixtures

The characteristics of dilute (0.1%) and moderately concentrated (2%) aqueous solutions of methyl cellulose, polymethacrylamidoglucose, and their blends, and also the composition of films based on them were studied by viscosimetry, rheology, and IR spectroscopy. The effect of the mixture composition on the conditions of gel formation in methyl cellulose solutions was studied.

Copolymers of 2-deoxy-2-methylacrylamido-D-glucose with tertiary and quaternary amino groups

Method for synthesis of graft-copolymers of a vinyl saccharide, 2-deoxy-2-methylacrylamido-D-glucose, and N,N-dimethylaminoethyl methacrylate was developed. Statistical copolymers with a controllable hydrophobic-hydrophilic balance were synthesized by alkylation of a statistical copolymer with various alkyl iodides.

Synthesis of 2-methacryloyl-5-hydroxy-3,3,5-trimethylisoxazolidine and copolymers thereof

Previously unknown 2-methacryloyl-5-hydroxy-3,3,5-trimethylisoxazolidine was prepared by the reaction of 5-hydroxy-3,3,5-trimethylisoxazolidine with methacryloyl chloride. Homopolymers of this compound and its copolymers with N-vinylformamide and N-vinylpyrrolidone were obtained by radical polymerization.

Modification of Vinylformamide by Michael Addition to Methyl Acrylate and Methyl Vinyl Ketone, and Copolymers Derived from the Resulting Products

Vinylformamide reacts with methyl acrylate and methyl vinyl ketone under conditions of base catalysis, following the Michael addition pattern, to give methyl 3-(vinylformylamino)propionate and previously unknown 4-(vinylformylamino)-2-butanone. Radical copolymerization of these compounds with vinylformamide and N-vinylpyrrolidone was studied.