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Featured researches published by E. Nelson Bowser.


Metabolism-clinical and Experimental | 1979

Role of endogenous somatostatin in the secretion of parathyroid hormone and calcitonin

Gerald A. Williams; Gary K. Hargis; John W. Ensinck; Subhash C. Kukreja; E. Nelson Bowser; Bruce S. Chertow; Walter J. Henderson

Our previous in vitro and in vivo studies demonstrated that exogenous somatostatin inhibited secretion of both parathyroid hormone (PTH) and calcitonin (CT). This study evaluates the possible role of endogenous somatostatin in PTH and CT secretion. Rats receiving somatostatin antiserum i.v. had significantly greater circulating levels of serum immunoreactive PTH (iPTH) and CT (iCT) than rats receiving normal rabbit serum. In in vitro studies with bovine parathyroid tissue, the addition of somatostatin antiserum to the medium significantly increased PTH secretion from basal, low calcium-stimulated and high calcium-suppressed parathyroid tissue. These combined observations strongly suggest that endogenous somatostatin must have a suppressive effect on PTH and CT secretion. The in vitro observations with isolated parathyroid tissue suggest that somatostatin is synthesized by cells within this tissue. These data strongly suggest that somatostatin is a locally-synthesized hormone that has a role in modulation of both PTH and CT secretion.


Experimental Biology and Medicine | 1978

Effect of long-term administration of epinephrine and propranolol on serum calcium, parathyroid hormone, and calcitonin in the rat.

Alfred N. Harney; Subhash C. Kukreja; Gary K. Hargis; Patricia A. Johnson; E. Nelson Bowser; Gerald A. Willams

Summary Injection of epinephrine to 250-to 300-g rats (0.3 mg/day for 2 weeks, followed by 0.6 mg/day for another 3 weeks) progressively increased the serum PTH and CT, whereas administration of approximately 40 mg of propranolol daily, in drinking water, progressively decreased the serum levels of both these hormones in comparison to control animals. The studies indicate that, similar to the shortterm effects observed in previous studies, long-term modification of β-adrenergic stimuli can affect PTH and CT secretions. The authors thank Mrs Barbara Lovett for her secreterial assistance.


Experimental Biology and Medicine | 1964

AMINO ACID TRANSPORT BY RAT PARATHYROID GLANDS IN VIVO: EFFECT OF LOW CALCIUM DIET.

Gerald A. Williams; Walter J. Henderson; E. Nelson Bowser

SummaryActive transport of α-aminoisobutyric acid by rat parathyroid tissue was much greater than by thyroid tissue under control conditions. Calcium deprivation doubled the parathyroid weight and tripled the α-aminoisobutyric acid transport into parathyroid cells, but had no effect on thyroid cells. The magnitude of this transport phenomenon is apparently a measure of physiologic activity of the parathyroid glands.The authors are indebted to Miss Ethel Hoffeins and Mrs. Joaquina Greene for technical assistance.


Microchemical Journal | 1963

A technique for the determination of weight and water content of minute tissue specimens

E. Nelson Bowser; Walter J. Henderson; Gerald A. Williams

Abstract A technique is described whereby the weight and water content of minute samples of tissue can be determined accurately and conveniently with inexpensive equipment. A comparison of tissue water-content determination by this technique with (a) a conventional technique that uses much larger samples of muscle tissue and (b) with previously reported values for muscle, liver, and kidney tissue indicated very good agreement. With this technique it was possible to determine the weight and water content of the rat parathyroid glands.


The Journal of Clinical Endocrinology and Metabolism | 1975

Effect of Glucocorticoids on Function of the Parathyroid Glands in Man

Robert F. Fucik; Subhash C. Kukreja; Gary K. Hargis; E. Nelson Bowser; Walter J. Henderson; Gerald A. Williams


The Journal of Clinical Endocrinology and Metabolism | 1975

Role of Adrenergic Stimuli in Parathyroid Hormone Secretion in Man

Subhash C. Kukreja; Gary K. Hargis; E. Nelson Bowser; Walter J. Henderson; Elmer W. Fisherman; Gerald A. Williams


Endocrinology | 1973

Evidence for a Role of Adenosine 3′, 5′–Monophosphate in Parathyroid Hormone Release

Gerald A. Williams; Gary K. Hargis; E. Nelson Bowser; Walter J. Henderson; N. J. Martinez


Endocrinology | 1974

Interrelationship of Parathyroid and Adrenocortical Function in Calcium Homeostasis in the Rat

Gerald A. Williams; William C. Peterson; E. Nelson Bowser; Walter J. Henderson; Gary K. Hargis; Norberto J. Martinez


Endocrinology | 1978

Effect of Somatostatin on Parathyroid Hormone and Calcitonin Secretion

Gary K. Hargis; Gerald A. Williams; W. Ann Reynolds; Bruce S. Chertow; Subhash C. Kukreja; E. Nelson Bowser; Walter J. Henderson


The Journal of Clinical Endocrinology and Metabolism | 1983

Effect of Exercise on Serum Calcium and Parathyroid Hormone

Nila M. Vora; Subhash C. Kukreja; Patricia York; E. Nelson Bowser; Gary K. Hargis; Gerald A. Williams

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Gerald A. Williams

University of Illinois at Chicago

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Gary K. Hargis

University of Illinois at Chicago

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Walter J. Henderson

University of Illinois at Chicago

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Subhash C. Kukreja

University of Illinois at Chicago

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Bruce S. Chertow

University of Illinois at Chicago

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Romi Sethi

University of Illinois at Chicago

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Alfred N. Harney

University of Illinois at Chicago

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Elmer W. Fisherman

University of Illinois at Chicago

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Gerald A. Willams

University of Illinois at Chicago

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