E. Nelson Bowser
University of Illinois at Chicago
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Featured researches published by E. Nelson Bowser.
Metabolism-clinical and Experimental | 1979
Gerald A. Williams; Gary K. Hargis; John W. Ensinck; Subhash C. Kukreja; E. Nelson Bowser; Bruce S. Chertow; Walter J. Henderson
Our previous in vitro and in vivo studies demonstrated that exogenous somatostatin inhibited secretion of both parathyroid hormone (PTH) and calcitonin (CT). This study evaluates the possible role of endogenous somatostatin in PTH and CT secretion. Rats receiving somatostatin antiserum i.v. had significantly greater circulating levels of serum immunoreactive PTH (iPTH) and CT (iCT) than rats receiving normal rabbit serum. In in vitro studies with bovine parathyroid tissue, the addition of somatostatin antiserum to the medium significantly increased PTH secretion from basal, low calcium-stimulated and high calcium-suppressed parathyroid tissue. These combined observations strongly suggest that endogenous somatostatin must have a suppressive effect on PTH and CT secretion. The in vitro observations with isolated parathyroid tissue suggest that somatostatin is synthesized by cells within this tissue. These data strongly suggest that somatostatin is a locally-synthesized hormone that has a role in modulation of both PTH and CT secretion.
Experimental Biology and Medicine | 1978
Alfred N. Harney; Subhash C. Kukreja; Gary K. Hargis; Patricia A. Johnson; E. Nelson Bowser; Gerald A. Willams
Summary Injection of epinephrine to 250-to 300-g rats (0.3 mg/day for 2 weeks, followed by 0.6 mg/day for another 3 weeks) progressively increased the serum PTH and CT, whereas administration of approximately 40 mg of propranolol daily, in drinking water, progressively decreased the serum levels of both these hormones in comparison to control animals. The studies indicate that, similar to the shortterm effects observed in previous studies, long-term modification of β-adrenergic stimuli can affect PTH and CT secretions. The authors thank Mrs Barbara Lovett for her secreterial assistance.
Experimental Biology and Medicine | 1964
Gerald A. Williams; Walter J. Henderson; E. Nelson Bowser
SummaryActive transport of α-aminoisobutyric acid by rat parathyroid tissue was much greater than by thyroid tissue under control conditions. Calcium deprivation doubled the parathyroid weight and tripled the α-aminoisobutyric acid transport into parathyroid cells, but had no effect on thyroid cells. The magnitude of this transport phenomenon is apparently a measure of physiologic activity of the parathyroid glands.The authors are indebted to Miss Ethel Hoffeins and Mrs. Joaquina Greene for technical assistance.
Microchemical Journal | 1963
E. Nelson Bowser; Walter J. Henderson; Gerald A. Williams
Abstract A technique is described whereby the weight and water content of minute samples of tissue can be determined accurately and conveniently with inexpensive equipment. A comparison of tissue water-content determination by this technique with (a) a conventional technique that uses much larger samples of muscle tissue and (b) with previously reported values for muscle, liver, and kidney tissue indicated very good agreement. With this technique it was possible to determine the weight and water content of the rat parathyroid glands.
The Journal of Clinical Endocrinology and Metabolism | 1975
Robert F. Fucik; Subhash C. Kukreja; Gary K. Hargis; E. Nelson Bowser; Walter J. Henderson; Gerald A. Williams
The Journal of Clinical Endocrinology and Metabolism | 1975
Subhash C. Kukreja; Gary K. Hargis; E. Nelson Bowser; Walter J. Henderson; Elmer W. Fisherman; Gerald A. Williams
Endocrinology | 1973
Gerald A. Williams; Gary K. Hargis; E. Nelson Bowser; Walter J. Henderson; N. J. Martinez
Endocrinology | 1974
Gerald A. Williams; William C. Peterson; E. Nelson Bowser; Walter J. Henderson; Gary K. Hargis; Norberto J. Martinez
Endocrinology | 1978
Gary K. Hargis; Gerald A. Williams; W. Ann Reynolds; Bruce S. Chertow; Subhash C. Kukreja; E. Nelson Bowser; Walter J. Henderson
The Journal of Clinical Endocrinology and Metabolism | 1983
Nila M. Vora; Subhash C. Kukreja; Patricia York; E. Nelson Bowser; Gary K. Hargis; Gerald A. Williams