E Parsai

SU‐E‐T‐310: Micro‐Dosimetry Study of the Radiation Dose Enhancement at the Gold‐Tissue Interface for Nanoparticle‐Aided Radiation Therapy

PURPOSEnGold nanoparticles (AuNP) have been proposed to be utilized for local dose enhancement in radiation therapy. Due to a very sharp spatial fall-off of the effect, the dosimetry associated with such an approach is difficult to implement in a direct measurement. This study is aimed at establishing a micro-dosimetry technique for experimental verification of dose enhancement in the vicinity of gold-tissue interface.nnnMETHODSnThe spatial distribution of the dose enhancement near the gold-tissue interface is modeled with Monte Carlo (MC) package MCNP5 in a 1-dimentional approach of a thin gold slab placed in an ICRU-4 component tissue phantom. The model is replicating the experiment, where the dose enhancement due to gold foils having thicknesses of 1, 10, and 100μm and areas of 12.5×25mm2 are placed at a short distance from clinical HDR brachytherapy (Ir-192) source. The measurements are carried out with a thin-film CdTe-based photodetector, having thickness <10μm, allowing for high spatial resolution at progressively increasing distances from the foil.nnnRESULTSnOur MC simulation results indicate that for Ir-192 energy spectrum the dose enhancement region extends over ∼1 mm distance from the foil, changing from several hundred at the interface to just a few percent. The trend in the measured dose enhancement closely follows the results obtained from MC simulations.nnnCONCLUSIONSnAuNPs have been established as promising candidates for dose enhancement in nanoparticle-aided radiation therapy, particularly, in the energy range relevant to brachytherapy applications. Most researchers study the dose enhancement with MC simulations, or experimental approaches involving biological systems, where achievable dose enhancements are difficult to quantify. Successful development of micro-dosimetry approaches will pave a way for direct assessment of the dose in experiments on biological models, shedding some light on apparent discrepancy between physical dose enhancement and biological effect established in studies of AuNP-aided radiation therapy. No conflict of interest.

SU-F-T-504: Non-Divergent Planning Method for Craniospinal Irradiation

PURPOSEnTraditional Craniospinal Irradiation (CSI) planning techniques require careful field placement to allow optimal divergence and field overlap at depth, and measurement of skin gap. The result of this is a necessary field overlap resulting in dose heterogeneity in the spinal canal. A novel, nondivergent field matching method has been developed to allow simple treatment planning and delivery without the need to measure skin gap.nnnMETHODSnThe CSI patient was simulated in the prone, and a plan was developed. Bilateral cranial fields were designed with couch and collimator rotation to eliminate divergence with the upper spine field and minimize anterior divergence into the lenses. Spinal posterior-to-anterior fields were designed with the couch rotated to 90 degrees to allow gantry rotation to eliminate divergence at the match line, and the collimator rotated to 90 degrees to allow appropriate field blocking with the MLCs. A match line for the two spinal fields was placed and the gantry rotated to equal angles in opposite directions about the match line. Jaw positions were then defined to allow 1mm overlap at the match line to avoid cold spots. A traditional CSI plan was generated using diverging spinal fields, and a comparison between the two techniques was generated.nnnRESULTSnThe non-divergent treatment plan was able to deliver a highly uniform dose to the spinal cord with a cold spot of only 95% and maximum point dose of 115.8%, as compared to traditional plan cold spots of 87% and hot spots of 132% of the prescription dose.nnnCONCLUSIONnA non-divergent method for planning CSI patients has been developed and clinically implemented. Planning requires some geometric manipulation in order to achieve an adequate dose distribution, however, it can help to manage cold spots and simplify the shifts needed between spinal fields.

SU-C-304-07: Are Small Field Detector Correction Factors Strongly Dependent On Machine-Specific Characteristics?

Purpose: The current small field dosimetry formalism utilizes quality correction factors to compensate for the difference in detector response relative to dose deposited in water. The correction factors are defined on a machine-specific basis for each beam quality and detector combination. Some research has suggested that the correction factors may only be weakly dependent on machine-to-machine variations, allowing for determinations of class-specific correction factors for various accelerator models. This research examines the differences in small field correction factors for three detectors across two Varian Truebeam accelerators to determine the correction factor dependence on machine-specific characteristics. Methods: Output factors were measured on two Varian Truebeam accelerators for equivalently tuned 6 MV and 6 FFF beams. Measurements were obtained using a commercial plastic scintillation detector (PSD), two ion chambers, and a diode detector. Measurements were made at a depth of 10 cm with an SSD of 100 cm for jaw-defined field sizes ranging from 3×3 cm{sup 2} to 0.6×0.6 cm{sup 2}, normalized to values at 5×5cm{sup 2}. Correction factors for each field on each machine were calculated as the ratio of the detector response to the PSD response. Percent change of correction factors for the chambers are presented relative to the primarymorexa0» machine. Results: The Exradin A26 demonstrates a difference of 9% for 6×6mm{sup 2} fields in both the 6FFF and 6MV beams. The A16 chamber demonstrates a 5%, and 3% difference in 6FFF and 6MV fields at the same field size respectively. The Edge diode exhibits less than 1.5% difference across both evaluated energies. Field sizes larger than 1.4×1.4cm2 demonstrated less than 1% difference for all detectors. Conclusion: Preliminary results suggest that class-specific correction may not be appropriate for micro-ionization chamber. For diode systems, the correction factor was substantially similar and may be useful for class-specific reference conditions.«xa0less

SU-E-T-382: Influence of Compton Currents On Profile Measurements in Small- Volume Ion Chambers

PURPOSEnIonization chambers in electron radiation fields are known to exhibit polarity effects due to Compton currents. Previously we have presented a unique manifestation of this effect observed with a microionization chamber. We have expanded that investigation to include three micro-ionization chambers commonly used in radiation therapy. The purpose of this project is to determine what factors influence this polarity effect for micro-chambers and how it might be mitigated.nnnMETHODSnThree chambers were utilized: a PTW 31016, an Exradin A-16, and an Exradin A- 26. Beam profile scans were obtained on a Varian TrueBeam linear accelerator in combination with a Wellhofer water phantom for 6, 9, and 12 MeV electrons. Profiles were obtained parallel and perpendicular to the chambers long axis, with both positive and negative collecting bias. Profiles were obtained with various chamber components shielded by 5 mm of Pb at 6 MeV to determine their relative contributions to this polarity effect.nnnRESULTSnThe polarity effect was observed for all three chambers, and the ratio of the polarity effect for the Exradin chambers is proportional to the ratio of chamber volumes. Shielding the stem of both Exradin chambers diminished, but did not remove the polarity effect. However, they demonstrated no out-of-field effect when the cable was shielded with Pb. The PTW chamber demonstrated a significantly reduced polarity effect without any shielding despite its comparable volume with the A-26.nnnCONCLUSIONSnThe sensitive volume of these micro-chambers is relatively insensitive to collecting polarity. However, charge deposition within the cable can dramatically alter measured ionization profiles. This is demonstrated by the removal of the out-of-field ionization when the cable is shielded for the Exradin chambers. We strongly recommend analyzing any polarity dependence for small-volume chambers used in characterization of electron fields.

SU-F-T-25: Design and Implementation of a Multi-Purpose Applicator for Pelvic Brachytherapy Applications

PURPOSEnThe current generation of inflatable multichannel brachytherapy applicators, such as the Varian Capri, have limited implementation to only vaginal and rectal cancers. While there are similar designs utilizing rigid, non-inflatable applicators, these alternatives could cause increased dose to surrounding tissue due to air gaps. Modification of the Capri could allow for easier treatment planning by reducing the number of channels and increased versatility by modifying the applicator to include an attachable single tandem for cervical or multiple tandems for endometrial applications.nnnMETHODSnA Varian Capri applicator was simulated in water to replicate a patient. Multiple plans were optimized to deliver a prescribed dose of 100 cGy at 5mm away from the exterior of the applicator using six to thirteen existing channels. The current model was expanded upon to include a detachable tandem or multiple tandoms to increase its functionality to both cervical and endometrial cancers. Models were constructed in both threedimensional rendering software and Monte Carlo to allow prototyping and simulations.nnnRESULTSnTreatment plans utilizing six to thirteen channels produced limited dosimetric differences between channel arrangements, with a seven channel plan very closely approximating the thirteen channels. It was concluded that only seven channels would be necessary in future simulations to give an accurate representation of the applicator. Tandem attachments were prototyped for the applicator to demonstrate the ease of which they could be included. Future simulation in treatment planning software and Monte Carlo results will be presented to further define the ideal applicator geometry CONCLUSION: The current Capri applicator design could be easily modified to increase applicability to include cervical and endometrial treatments in addition to vaginal and rectal cancers. This new design helps in a more versatile single use applicator that can easily be inserted and to further reduce dose to critical structures during brachytherapy treatments.

SU-G-BRB-12: Polarity Effects in Small Volume Ionization Chambers in Small Fields

PURPOSEnDosimetric quantities such as the polarity correction factor (Ppol) are important parameters for determining the absorbed dose and can influence the choice of dosimeter. Ppol has been shown to depend on beam energy, chamber design, and field size. This study is to investigate the field size and detector orientation dependence of Ppol in small fields for several commercially available micro-chambers.nnnMETHODSnWe evaluate the Exradin A26, Exradin A16, PTW 31014, PTW 31016, and two prototype IBA CC-01 micro-chambers in both horizontal and vertical orientations. Measurements were taken at 10cm depth and 100cm SSD in a Wellhofer BluePhantom2. Measurements were made at square fields of 0.6, 0.8, 1.0, 1.2, 1.4, 2.0, 2.4, 3.0, and 5.0 cm on each side using 6MV with both ± 300VDC biases. PPol was evaluated as described in TG-51, reported using -300VDC bias for Mraw. Ratios of PPol measured in the clinical field to the reference field are presented.nnnRESULTSnA field size dependence of Ppol was observed for all chambers, with increased variations when mounted vertically. The maximum variation observed in PPol over all chambers mounted horizontally was <1%, and occurred at different field sizes for different chambers. Vertically mounted chambers demonstrated variations as large as 3.2%, always at the smallest field sizes.nnnCONCLUSIONnLarge variations in Ppol were observed for vertically mounted chambers compared to horizontal mountings. Horizontal mountings demonstrated a complicated relationship between polarity variation and field size, probably relating to differing details in each chambers construction. Vertically mounted chambers consistently demonstrated the largest PPol variations for the smallest field sizes. Measurements obtained with a horizontal mounting appear to not need significant polarity corrections for relative measurements, while those obtained using a vertical mounting should be corrected for variations in PPol.

SU-F-T-557: Evaluation of Detector Response in Rectangular Small Field Dosimetry

PURPOSEnAs stereotactic treatment modalities grow towards becoming the standard of care, the need for accurate dose computation in small fields is becoming increasingly essential. The purpose of this study is to evaluate the response of different detectors, intended for small field dosimetry, in jaw defined small rectangular fields by analyzing output factors from a stereotactic clinical accelerator.nnnMETHODSnTwo Dosimeters, the Exradin A26 Microionization Chamber (Standard Imaging) and Edge Diode Detector (Sun Nuclear) were used to measure output factors taken on the Varian Edge Stereotactic Linear accelerator. Measurements were taken at 6MV and 6FFF at 10cm depth, 100cm SSD in a 48×48×40cm3 Welhoffer BluePhantom2 (IBA) with X and Y jaws set from 0.6 to 2.0cm. Output factors were normalized to a 5×5cm2 machine-specific reference field. Measurements were made in the vertical orientation for the A26 and horizontal orientation for both the A26 and Edge. Output factors were measured as: OFFS = MFS /Mref where MFS and Mref are the measured signals for the clinical field and the reference field, respectively. Measured output factors were then analyzed to establish relative responses of the detectors in small fields.nnnRESULTSnAt 6MV the Edge detector exhibited a variation in output factors dependent on jaw positioning (X-by-Y vs Y-by-X) of 5.7% of the 5×5cm reference output and a variation of 3.33% at 6FFF. The A26 exhibited variation of output factor dependent on jaw positioning of upto 7.7% of the 5×5cm reference field at 6MV and upto 5.33% at 6FFF.nnnCONCLUSIONnBoth the Edge detector and A26 responded as expected at small fields however a dependence on the jaw positioning was noted. At 6MV and 6FFF the detector response showed an increased dependence on the positioning of the X jaws as compared to the positioning of the Y jaws.

SU-E-T-361: Energy Dependent Radiation/light-Field Misalignment On Truebeam Linear Accelerator

Purpose: Verifying the co-incidence of the radiation and light field is recommended by TG-142 for monthly and annual checks. On a digital accelerator, it is simple to verify that beam steering settings are consistent with accepted and commissioned values. This fact should allow for physicists to verify radiation-light-field co-incidence for a single energy and accept that Result for all energies. We present a case where the radiation isocenter deviated for a single energy without any apparent modification to the beam steering parameters. Methods: The radiation isocenter was determined using multiple Methods: Gafchromic film, a BB test, and radiation profiles measured with a diode. Light-field borders were marked on Gafchromic film and then irradiated for all photon energies. Images of acceptance films were compared with films taken four months later. A phantom with a radio-opaque BB was aligned to isocenter using the light-field and imaged using the EPID for all photon energies. An unshielded diode was aligned using the crosshairs and then beam profiles of multiple field sizes were obtained. Field centers were determined using Omni-Pro v7.4 software, and compared to similar scans taken during commissioning. Beam steering parameter files were checked against backups to determine that the steering parameters were unchanged. Results: There were no differences between the configuration files from acceptance. All three tests demonstrated that a single energy had deviated from accepted values by 0.8 mm in the inline direction. The other two energies remained consistent with previous measurements. The deviated energy was re-steered to be within our clinical tolerance. Conclusions: Our study demonstrates that radiation-light-field coincidence is an energy dependent effect for modern linacs. We recommend that radiation-light-field coincidence be verified for all energies on a monthly basis, particularly for modes used to treat small fields, as these may drift without influencing results from other tests.

SU-E-T-271: Direct Measurement of Tenth Value Layer Thicknesses for High Density Concretes with a Clinical Machine

Purpose: Use of high density concrete for radiation shielding is increasing, trading cost for space savings associated with the reduced tenth value layer (TVL). Precise information on the attenuation properties of high-density concretes is not readily present in the literature. A simple approximation is to scale the TVLs from NCRP 151 according relative increase in density. Here we present measured TVLs for heavy concretes of various densities using a built-in shielding test port. Methods: Concrete densities tested range from 2.35 g cc−1 (147 pcf) to 5.6 g cc−1 (350 pcf). Measurements were taken using 6MV, 6FFF, and 10FFF on a Varian Truebeam linear accelerator. Field sizes of 4x4, 9x9 and 30x30 cm2 were measured. A PTW 31013 Farmer chamber with a buildup cap was positioned 5.5 m from isocenter along the beam CAX. Concrete thicknesses were incremented in 5 cm intervals. Comparison TVLs were determined by scaling the NCRP 151 TVLs by the density ratio between the sample and standard density. Results: The trend from the first to equilibrium TVL was an increase in thickness, compared with MC modeling, which predicted a decrease. Measured TVLs for 6 MV were reduced by as much as 8.9 cm for TVL₁ and 3.4 cm for TVLE compared to values scaled from NCRP 151. There was 1–3 mm difference in TVL between measurements done at 4x4 versus 30x30 cm2. TVL₁ for 6FFF was 1.1 cm smaller than TVL₁ for 6MV, but TVLE was consistent to within 4 mm. TVL₁ and TVLE for 10FFF were reduced by 8.8 and 3.7 cm from scaled NCRP values, respectively. Conclusions: We have measured the TVL thicknesses for various concretes. Simple density scaling of the values in NCRP 151 is a conservatively safe approximation, but actual TVLs may be reduced enough to eliminate some of the expense of installation. Daniel Harrell and Jim Noller are employees of Shielding Construction Solutions, Inc, the shielding construction company that built the vault discussed in this abstract. Manjit Chopra is an employee of Universal Minerals International, Inc, the company that provided the aggregates for the high density concretes used in the vault construction.

SU-E-T-243: Design of a Novel Testing Port for Radiation Protection and Shielding Measurements

Purpose: The majority of radiation shielding research utilizes Monte Carlo simulation because of the difficulty in eliminating secondary radiations from measurements. We have designed a test port into a primary barrier of our newest vault to allow for shielding measurements while ensuring adequate protection to the public and staff during normal machine operation. This port allows for measurement of attenuation values of shielding materials, differential dose albedos, and radiation scatter fractions. Methods: The vault design utilized the maze as part of a compound primary barrier. The test port is contained within the maze and is centered along isocenter. The inner 30 cm has a 20×20 cm2 opening, while the remaining length has a 30×30 cm2 opening. The block that contains the port has a density of 200 pcf to minimize internal scatter. The 30×30 cm2 opening is occupied by removable 215 pcf concrete blocks. The innermost and outermost blocks activate an interlock wired into the beam-enable loop. This disallows beam-on in treatment mode if the interlock isn’t closed. The interlock can be overridden in service mode, or by-passed via an override switch in case of circuit failure. Results: The test port was installed in August. The beam is disabled when the interlock is tripped. Measurements taken when the primary beam is not incident on the port are indistinguishable from background. Ambient dose levels surrounding the vault with the designed shielding blocks in place are all within allowable limits for occupational workers. Conclusions: We have designed and installed a unique testing port for radiation protection and shielding measurements. This port is appropriately interlocked and designed to mitigate any risks of incidental exposure to staff or members of the public. The test port design allows measurements with “good geometry” and efficient removal of contaminating sources of radiation present in many shielding measurements. Daniel Harrell and Jim Noller are employees of Shielding Construction Solutions, Inc, the shielding construction company that built the vault discussed in this abstract. Manjit Chopra is an employee of Universal Minerals International, Inc, the company that provided the aggregates for the high density concretes used in the vault construction.