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Dive into the research topics where E. Sarinho is active.

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Featured researches published by E. Sarinho.


Clinical & Experimental Allergy | 2007

Safety of anti-immunoglobulin E therapy with omalizumab in allergic patients at risk of geohelminth infection

Alvaro A. Cruz; F. Lima; E. Sarinho; G. Ayre; C. Martin; H. Fox; P. J. Cooper

Background Although the role of immunoglobulin E (IgE) in immunity against helminth parasites is unclear, there is concern that therapeutic antibodies that neutralize IgE (anti‐IgE) may be unsafe in subjects at risk of helminth infection.


Allergologia Et Immunopathologia | 2009

Production of interleukin-10 in asthmatic children after Beta-1-3-glucan

E. Sarinho; Décio Medeiros; Deborah Schor; A. Rego Silva; V. Sales; Maria Eugênia Farias Almeida Motta; Agnes M. da Costa; A. Azoubel; José Angelo Rizzo

BACKGROUND Beta-1-3 Glucan is a polysaccharide extracted from Saccharomyces cerevisiae with a possible immunomodulating action that may have a favourable action on asthma symptoms and other allergic diseases. An experimental study carried out using a murine respiratory model detected a decrease in pulmonary tissue eosinophilia, as well as an increase in Interleukin-10 (IL-10) after glucan use. METHODS This open, exploratory study with blind outcome evaluation included asthmatic children between 6 and 12 years of age with mild to moderate persistent asthma and inadequate disease control (rescue medication needed more than twice a week) in spite of inhaled budesonide 400 microg/day. After a four week run-in period, subcutaneous Beta-1-3-glucan injections were given weekly for the first four weeks and then every two weeks for the last four weeks. IL-10 levels, measured by the immunoenzymatic method (ELISA), were compared before and after glucan administration. RESULTS Twenty patients (14 male and 6 female) were included. Mean IL-10 levels were 6.4 pg/ml and 11.3 pg/ml before and after glucan, respectively (p = 0.02). There was also a reduction of asthmatic symptoms score at the end of study. CONCLUSIONS This is the first study which shows that subcutaneous particulate Beta-1-3-glucan increases serum IL-10 levels in asthmatics. The possibility of glucan being able to modulate allergic sensitisation and having a beneficial action in restoring Th2 function should be assessed by means of properly planned controlled clinical trials, as it may represent a new therapeutic strategy.


Allergologia Et Immunopathologia | 2009

Sensitisation to aeroallergens among asthmatic and non-asthmatic adolescents living in a poor region in the Northeast of Brazil

E. Sarinho; J. Mariano; S.W. Sarinho; Décio Medeiros; José Angelo Rizzo; Dirceu Solé

OBJECTIVES To assess the kind and frequency of sensitisation to aeroallergens (skin prick test - SPT) of asthmatic and non-asthmatic adolescents (13-14 years old) living in the city of Caruaru, Northeast of Brazil, and to analyse their exposure to some environmental factors. METHOD A case-control study was conducted with asthmatic (50) and non-asthmatic (150) adolescents diagnosed by the International Study of Asthma and Allergies in Childhood (ISAAC) written questionnaire. All were submitted to SPT with aeroallergens (house dust mites, cat and dog epithelium, cockroaches, moulds and grass) and completed a questionnaire to evaluate their environmental exposure. RESULTS There were no significant differences between groups regarding gender, age, number of siblings and environmental exposure. Asthmatic subjects exhibited a higher frequency of positive SPTs than non-asthmatic subjects (54.0% vs 33.3%, p=0.009) mainly due to Periplaneta americana (34.0% vs 12.7%, p=0.0007 respectively) and Canis familiaris (20.0% vs 8.7%, p=0.029). CONCLUSION Although sensitisation to aeroallergens was high among non-asthmatic adolescents, asthma was associated with parental history of atopic disease and sensitisation to P. americana and Canis familiaris but not to D. pteronyssinus showing that local studies are mandatory for the tailoring of appropriate management of allergic diseases.


Allergologia Et Immunopathologia | 2012

Assessing caries, dental plaque and salivary flow in asthmatic adolescents using inhaled corticosteroids.

N.C. Santos; S. Jamelli; Luciana Scarlazzari Costa; C. Baracho Filho; Décio Medeiros; José Angelo Rizzo; E. Sarinho

BACKGROUND A number of studies have reported that inhaled corticosteroids may cause a greater incidence of caries, reduced salivary flow, changes in saliva composition and an increased frequency of dental plaque, probably through alterations in the oral microbiota. The objective was to compare the frequency of caries, dental plaque and non-stimulated salivary flow rate among asthmatic adolescents using inhaled corticosteroids and non-asthmatic adolescents, as well as the salivary biochemical parameters (pH and leucocytes) in both groups. METHODS This research has a descriptive cross-sectional design to compare dental health of 40 asthmatics on inhaled corticosteroids and 40 non-asthmatic adolescents (median age 13 years). RESULTS The findings were a higher number of tooth surfaces affected by dental caries (median 4 versus 1.5), and more dental plaques (median 70.5 versus 60.7) among asthmatic adolescents. They also had a significantly higher frequency of salivary leucocytes. The non-stimulated salivary flow was similar in both groups. CONCLUSIONS The results suggest an association between the use of inhaled corticosteroids and an increased risk of dental caries and bacterial plaque, which calls for special attention of these patients by doctors and dental health professionals.


Allergologia Et Immunopathologia | 2014

Ascaris lumbricoides infection in urban schoolchildren: Specific IgE and IL-10 production ,

Valdênia Maria Oliveira Souza; Décio Medeiros; Iana Rafaela Fernandes Sales; Vlaudia Maria Assis Costa; Almerinda Rego Silva; José Angelo Rizzo; Dirceu Solé; E. Sarinho

BACKGROUND Helminth infections and allergies are diseases with intense Th2 lymphocytes participation and characterised by a high IgE and Interleukin-(IL) IL-4, IL-5 production and eosinophilia. However, helminths also induce IL-10 production, which may alter the outcome of allergic diseases in infected patients. OBJECTIVE This experimental study analyses the relationship between IL-10 production by cell culture from geohelminth infected and non-infected children and specific IgE to Ascaris lumbricoides (Asc) or Blomia tropicalis (BT). METHODS IL-10 content in supernatant from peripheral blood mononuclear cell culture from nine helminth infected and eleven non-infected patients was determined by ELISA after in vitro stimulation with Asc or BT extracts. RESULTS A positive association was observed between total IgE levels and anti-Ascaris and anti-Blomia tropicalis specific IgE, independent of infection status. For both helminth-infected and non-infected groups, there was no difference in IL-10 production in response to Asc extract, even though anti-Ascaris IgE levels were higher in the latter group. In response to BT stimulus, a lower production of IL-10 by the geohelminth-infected group was observed, but with no relationship between IL-10 production and specific IgE to BT. CONCLUSION The results suggest that anti-Ascaris IgE in non-infected patients may be associated to a resistance to parasites. Levels of specific IgE to parasite antigens or B. tropicalis allergen were not impaired by IL-10 production in children from an urban area in which geohelminthiasis is endemic.


The Journal of Allergy and Clinical Immunology | 2006

Safety of Anti-IgE Therapy with Omalizumab in Allergic Patients at Risk of Geohelminth Infection

P.J. Cooper; F. Lima; E. Sarinho; G. Ayre; C. Martin; H. Fox; Alvaro A. Cruz


Brazilian Journal Allergy and Immunology | 2018

Consenso Brasileiro sobre Alergia Alimentar: 2018 - Parte 1 - Etiopatogenia, clínica e diagnóstico. Documento conjunto elaborado pela Sociedade Brasileira de Pediatria e Associação Brasileira de Alergia e Imunologia

Dirceu Solé; Luciana Rodrigues Silva; Renata Rodrigues Cocco; Cristina Helena Targa Ferreira; Roseli Oselka Sarni; Lucila Camargo Oliveira; Antonio Carlos Pastorino; Virgínia Weffort; Mauro Batista de Morais; Bruno Paes Barreto; José Carlison Oliveira; Ana Paula Beltran Moschione Castro; Jackeline Motta Franco; Herberto José Chong; Nelson Augusto Rosário; Maria Luisa Oliva Alonso; E. Sarinho; Ariana Yang; Hélcio de Sousa Maranhão; Mauro Sérgio Toporovski; Matias Epifanio; Neusa Falbo Wandalsen; Norma Rubini


Brazilian Journal Allergy and Immunology | 2018

Consenso Brasileiro sobre Alergia Alimentar: 2018 - Parte 2 - Diagnóstico, tratamento e prevenção. Documento conjunto elaborado pela Sociedade Brasileira de Pediatria e Associação Brasileira de Alergia e Imunologia

Dirceu Solé; Luciana Rodrigues Silva; Renata Rodrigues Cocco; Cristina Helena Targa Ferreira; Roseli Oselka Sarni; Lucila Camargo Oliveira; Antonio Carlos Pastorino; Virgínia Weffort; Mauro Batista de Morais; Bruno Paes Barreto; José Carlison Oliveira; Ana Paula Beltran Moschione Castro; Jackeline Motta Franco; Herberto José Chong; Nelson Augusto Rosário; Maria Luisa Oliva Alonso; E. Sarinho; Ariana Yang; Hélcio de Sousa Maranhão; Mauro Sérgio Toporovski; Matias Epifanio; Neusa Falbo Wandalsen; Norma Rubini


The Journal of Allergy and Clinical Immunology | 2011

Sensitization to Cockroaches: Comparison Between Different Allergenic Extracts for Skin Prick Test

E. Sarinho; M.I.L. Lopes; P. Miranda; José Angelo Rizzo; Almerinda Rego Silva; Décio Medeiros; Dirceu Solé


The Journal of Allergy and Clinical Immunology | 2006

Prevalence of Asthma and Rhinitis Among Adolescents Living in Urban or Rural Areas of Different Cities of Brazil

Dirceu Solé; Vitor Emanuel Cassol; Almerinda Rego Silva; L.C. Bandim; T. Rizatto; S.P. Teche; E. Sarinho

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Dirceu Solé

Federal University of São Paulo

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Décio Medeiros

Federal University of Pernambuco

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José Angelo Rizzo

Federal University of Pernambuco

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Almerinda Rego Silva

Federal University of Pernambuco

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Neusa Falbo Wandalsen

Federal University of São Paulo

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Charles Kirov Naspitz

Federal University of São Paulo

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Marcia Carvalho Mallozi

Federal University of São Paulo

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A. Rego Silva

Federal University of Pernambuco

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