E. Willems

Effect of Phosphate On Oxygen-hemoglobin Affinity, Diphosphoglycerate and Blood-gases During Recovery From Diabetic-ketoacidosis

The effects of intravenous phosphate administration on the hemoglobin-oxygen affinity, the 2,3 diphosphoglycerate level and blood gases were investigated in twenty severe diabetic patients with ketoacidosis in the intensive care unit. Ten received phosphate (mean total amount for each patient = 300 mEq) and the others did not. The only significant difference noted in all indices measured during the recovery period of eight days was seen to occur after 48 h; the P50 in vivo (Torr) was slightly higher in the group who received phosphate (22.5±1.6 vs 20.5±2.2) and for the Hill coefficient (2.4±0.2 vs 2.2±0.1). This drop in the oxygen affinity of hemoglobin may be useful in subjects at risk of hypoxia, for example those with cardiac or respiratory failure and justifies the use of phosphate in the first 48 h of treatment of patients with diabetic ketoacidosis.

Effects of two inotropic drugs, dopamine and dobutamine, on pulmonary gas exchange in artificially ventilated patients.

AbstractThe inotropic agents, dopamine (DP) and dobutamine (DB), both decrease PaO2, probably by a resistribution of the

Détermination de la courbe de dissociation standard de l'oxyhémoglobine du cheval et influence, sur cette courbe, de la température, du pH et du diphosphoglycérate.

{{\dot VA} \mathord{\left/ {\vphantom {{\dot VA} {\dot Q}}} \right. \kern-\nulldelimiterspace} {\dot Q}}

[Determination of the standard oxyhemoglobin dissociation curve in horses. Effects of temperature, pH and diphosphoglycerate]

ratio. The aim of this study was to assess the effect of both drugs on the

Interaction of bilirubin on the oxyhemoglobin saturation measured by photometry

{{\dot VA} \mathord{\left/ {\vphantom {{\dot VA} {\dot Q}}} \right. \kern-\nulldelimiterspace} {\dot Q}}

Interférence de la bilirubine sur la saturation de l'oxyhémoglobine mesurée par photométrie

ratio, using the multiple inert gas elimination method. Ten artificially ventilated patients (eight males), aged 45–74 years were investigated. Blood gases, cardiac output and concentrations of inert gases were measured before and 30 min after infusion of DB or DP. DP and DB were administered alternatively at a rate of 5 μg·k-1 min-1. The decrease in PaO2 was significantly greater with DP (12±9 torr) than with DB (7±9 torr) (P< 0.01) Both drugs similarly increased cardiac ouput: +2.6l·min-1±1.4 for DP and 2.2l·min-1±1.5 for DB. Both DP and DB significantly (P< 0.01) increased the perfusion of alveoli with