Earl G. Hubert

PYELONEPHRITIS. V. ROLE OF SERUM BACTERICIDAL ACTIVITY AND ANTIBODY IN ACUTE PYELONEPHRITIS IN THE RABBIT.

Summary Intravenous injection of rabbits with Str. faecalis produced an acute pyelonephritis which spontaneously resolved in a few weeks. This infection was accompanied by vigorous antibacterial antibody (agglutinating and hemagglutinating) production which was not associated with increase in serum bactericidal activity as tested. There appeared to be no correlation between individual rabbit pre-infection serum bactericidal activity and the quantitative bacteriological findings in the kidney. The difference between the outcome of infection in the rabbit and rat has not been explained by the immunological studies performed.

Pigment Formation in L-forms of Serratia marcescens

SUMMARY: L-forms of Serratia marcescens were produced and serially transferred in osmotically stabilized agar with penicillin. The bacterial form was pigmented, while the L-form colony was not. Lack of colour in the L-form colony was not due to pigment diffusion into the agar; an extract of agar with L-form growth did not show an absorption spectrum for prodigiosin.

PYELONEPHRITIS. IV. ROLE OF SERUM BACTERICIDAL ACTIVITY AND ANTIBODY IN CHRONIC ENTEROCOCCAL PYELONEPHRITIS IN THE RAT.

Summary Pyelonephritis produced in rats by intravenous inoculation of Str. faecalis becomes established in the presence of normal serum bactericidal activity against the infecting organism. The infection persists throughout the life of the rat despite the eventual appearance of circulating antibacterial antibodies. This finding may be partially explained by the fact that these antibodies do not enhance normal serum bactericidal activity as tested.