Earl H. Dearborn

Antidiuretic effects of physostigmine and atropine in the dog.

Summary Physostigmine and atropine produce antidiuresis in the dog by increasing tubular reabsorption of water. The doses required, however, are large and usually accompanied by signs of toxicity.

Inhibition of the appearance of phenol red in frog kidney tubules in vitro.

Summary Cinchoninic acid and nine of its derivatives have been studied with respect to the inhibition of the appearance of phenol red color in the lumina of the tubules of frog kidney slices in vitro. Three of these have been found more active in this respect than is caronamide and one equally active.

Filtrable Agents Lethal for Ducks.

Summary Filtrable agents, lethal for ducks, were obtained by Seitz filtration of plasma from ducks with lophurae, cathe-merium, relictum or elongatum malaria. Attempts to free the malaria of the filtrable agent were unsuccessful.

Effect of 3-Hydroxy-2-phenylcinchoninic Acid on Renal Secretion of Phenyl Red and Penicillin.

Summary Similar to carinamide, 3-hydroxy-2-phenylcinchoninic acid causes higher concentrations of penicillin in the plasma when injected before the administration of the penicillin. Both substances also decrease the rate of excretion of phenol red. The activities of the two drugs are roughly of the same order of magnitude. This increase in concentration of penicillin in the plasma and decrease in rate of excretion of phenol red is attributed to a blocking of the renal tubular secretory mechanism. We wish to thank Sara Ann Verplanck and Irene T. Payne for technical assistance.

Curative Action of Drugs in Lophurae Malaria of the Duck.

Summary A number of drugs have been examined for their curative action in lophurae malaria in the duck. Pamaquine appears to cure a fair percentage of the birds, while quinine, quinacrine, chloroquine and a number of other drugs do not.