Ed H.M. Hartman

Donor-site morbidity after free vascularized autogenous fibular transfer: subjective and quantitative analyses.

The purpose of this study was to determine the subjective and quantitative donor-site morbidity after removal of a free vascularized fibula flap for autoreconstruction. Ten patients and six age-matched, healthy control subjects were included in this study. The postoperative periods ranged from 6 to 87 months. Subjective donor-site morbidity was assessed with a patient questionnaire and the Enneking system. For quantification of donor-site morbidity, gait was evaluated during normal walking, walking under visual and cognitive constraints, and walking at a velocity higher than the preferred one. In general, the patient perception of donor-site morbidity was low. Complaints were frequently mentioned, however, including pain (60 percent), dysesthesia (50 percent), a feeling of ankle instability (30 percent), and inability to run (20 percent). Gait analyses revealed that patients walked at a lower preferred velocity, compared with control subjects. Furthermore, they demonstrated significant increases in the coefficients of variation of stride time during walking under visual and cognitive loads and during walking at a velocity higher than the preferred one, compared with normal walking. These increases were not observed for control subjects. These findings suggest that the reautomatization of gait is affected among patients. This study demonstrates that fibula harvesting is associated with low subjective morbidity but frequent complaints. Walking during complex tasks and at high velocities reveals that restoration of gait is not complete after partial fibulectomy.

Donor-Site Complications in Vascularized Bone Flap Surgery

Microvascular osteocutaneous free flaps have given reconstructive surgeons a powerful tool in the reconstruction of composite defects in head and neck surgery. Radial forearm, scapula, iliac crest, and fibula flaps have been used extensively in mandibular reconstruction. The inevitable donor-site morbidity of these osteocutaneous flaps has received less attention than the reconstructive advantages. We have reviewed the literature for each type of flap to determine the kind, incidence, and consequences of flap associated morbidity. In the future, tissue-engineered prefabricated free flaps might play an important role.

In Vivo Magnetic Resonance Imaging Explorative Study of Ectopic Bone Formation in the Rat

In animal studies of tissue engineering of bone, histology remains the standard for assessing bone formation. As longitudinal studies with this method are feasible only at the cost of large numbers of animals, we looked for an alternative. Therefore, demineralized bone matrix (DBM) and inactivated demineralized bone matrix (iDBM) implants were subcutaneously implanted in a rat. At 1, 3, 5, and 7 weeks postimplantation soft X-ray and magnetic resonance imaging (MRI) were done to monitor bone formation in the implants. At 7 weeks, the animal was killed and the implants were retrieved for histology. Our results showed that in vivo MRI is well suited to assess bone formation larger than 0.5 mm in diameter and to monitor the complete three-dimensional shape of the newly formed bone noninvasively and longitudinally. The MRI results matched well with the histology results obtained at 7 weeks. In contrast, X-ray imaging appeared inappropriate to monitor the bone formation process in DBM.

Aesthetic refinements and reoperative procedures following 370 consecutive DIEP and SIEA flap breast reconstructions: important considerations for patient consent.

BackgroundBreast reconstruction often requires multiple operations. In addition to potential complications requiring reoperation, additional procedures are frequently essential in order to complete the reconstructive process, with aesthetic outcome and breast symmetry shown to be the most important factors in patient satisfaction. Despite the importance of these reoperations in decision-making and the consent process, a thorough review of the need for such operations has not been definitively explored.MethodsA review of 370 consecutive autologous breast reconstructions (326 patients) was undertaken, comprising 365 deep inferior epigastric artery perforator (DIEP) flaps and 5 superficial inferior epigastric artery (SIEA) flaps. The need for additional procedures for either complications or aesthetic refinement following initial breast reconstruction was assessed.ResultsOverall, there was an average of 1.06 additional interventions for every patient carried out after primary reconstructive surgery. Of 326 patients, 46 underwent early postoperative operations for surgical complications (0.17 additional operations per patient as a consequence of complications). Procedures for aesthetic refinement included those performed on the reconstructed breast, contralateral breast, or abdominal donor site. Procedures for aesthetic refinement included nipple reconstruction, nipple–areola complex tattooing, dog-ear correction, liposuction, lipofilling, scar revision, mastopexy, and reduction mammaplasty.ConclusionWhile DIEP flap surgery for breast reconstruction provides favorable results, patients frequently require additional procedures to improve aesthetic outcomes. The need for reoperation is an important part of the consent process prior to reconstructive surgery, and patients should recognize the likelihood of at least one additional procedure following initial reconstruction.

Anteromedial thigh flaps: an anatomical study to localize and classify anteromedial thigh perforators.

Until now, research on flaps in the anteromedial thigh region has focused on flaps in specific regions. To elucidate the complete pattern of suitable anteromedial thigh perforators, an anatomical study was performed by dissecting nine thighs from different cadavers. The ideal perforator has maximum length and diameter and runs through a septum. According to the data found in our study, these perforators can predominantly be found in the middle third of the anteromedial thigh region. All of the three main thigh vessels supply perforators which can be used for flaps. Pertaining to length and diameter the most suitable perforators originate from the deep femoral artery, which can be found in the proximal and middle third of the anteromedial thigh. Musculocutaneous perforators are found to be longer than septocutaneous perforators. Because of their position, the proximal and distal third perforators should preferentially be used for local pedicled flaps. Defects in the pelvic area and around the knee can be closed with perforator flaps from the proximal and distal anteromedial thigh, respectively. Because of their diameter, length, and number, the middle third perforators should be the first choice for harvesting free flaps. Skin closure is easily achieved in the anteromedial thigh region even when larger flaps are used.

Preoperative injection using a diluted anesthetic/adrenaline solution significantly reduces blood loss in reduction mammaplasty

&NA; Breast reductions are very common operations in the plastic surgical practice. The cosmetic results are generally satisfactory but are often accompanied with large volumes of blood lost. In this study, the reduction of blood loss together with other positive and negative effects of a preoperatively diluted anesthetic/adrenaline solution was tested. A group of 41 female patients treated with the infiltration solution was compared with a group of 29 female patients treated without the solution. No statistical differences were found in age at operation, weight, length, Quetelet index, amount of tissue resected, preoperative hemoglobin and hematocrit, postoperative drainage, duration of operation, and the viability of the skin flaps (p > 0.05). Blood loss was significantly less in the adrenaline‐treated group measured in several ways (p < 0.0001). There were more adrenaline‐treated patients with less hospitalization time compared with the nontreated group (p = 0.0858). In conclusion, diluted anesthetic/adrenaline solution significantly reduces blood loss in reduction mammaplasty without any adverse effects. (Plast. Reconstr. Surg. 102: 373, 1998.)

Demineralized Bone Matrix-Induced Ectopic Bone Formation in Rats: In Vivo Study with Follow-up by Magnetic Resonance Imaging, Magnetic Resonance Angiography, and Dual-Energy X-Ray Absorptiometry

The aim of this study was to further explore the use of magnetic resonance imaging (MRI), magnetic resonance angiography (MRA), and dual-energy X-ray absorptiometry (DEXA) to assess bone formation and blood circulation in a pedicled bone graft substitute. In 14 Wistar rats, initially 10 weeks old, heterogeneous demineralized femur bone matrix implants were wrapped in pedicled adductor thigh muscle flaps. One rat died after surgery. Subsequently, bone formation and maintenance of blood vessel functionality were evaluated in six rats 6 weeks postimplantation by means of in vivo MRI/MRA and postmortem histomorphometry. The other seven rats were left for 12 weeks, whereafter bone formation was evaluated by in vivo DEXA and postmortem histomorphometry. The results demonstrated that after 6 weeks bone formation was present in four of six animals, quantified as 42 (+/-35)% and 25 (+/-19)% by means of MRI and histomorphometry, respectively. MRA was able to show patency of the pedicles of these four rats only, which suggests that the lack of blood supply in the other two rats is the cause of the failure to form bone. In the 12-week group, histology showed increased bone formation without signs of osteolysis, which was quantified histomorphometrically to be as high as 48 (+/-15)%. DEXA failed to show bone formation. It is concluded that in vivo MRI proved to be a reliable method for monitoring ectopic bone formation in a rat model, whereas in vivo DEXA was unable to detect the implants. Furthermore, in vivo MRA proved to be a useful technique for studying the circulation of muscle flaps in this animal model.

Contralateral reinnervation of midline muscles in facial paralysis

We report on a patient with recovery of activity of the left orbicularis oris and nasalis muscles 3 months after a complete left facial palsy. Stimulation of the affected facial nerve evoked no responses, whereas contralateral facial nerve stimulation showed polyphasic responses with very long latencies in the nasalis and orbicularis oris muscles. Needle electromyography (EMG) revealed abnormal spontaneous activity in the left orbicularis oris muscle. The motor unit action potentials on the left side of the face could be recruited only during marked contraction of the corresponding muscles on the right and were of low voltage and polyphasic (“nascent potentials”). Contralateral reinnervation is probably due to sprouting of terminal branches crossing the midline of the face and innervating bundles of muscle fibers on the affected side. This phenomenon seems unfamiliar to most clinicians. Whether the activity is due to conduction along nerve fibers or muscle fibers crossing the midline is discussed.

Hypopharyngeal reconstruction with an anterolateral thigh flap after laryngopharyngeal resection: Results of a retrospective study on 20 patients

The aim of this retrospective study is to evaluate short- and long-term postoperative morbidity and mortality of hypopharyngeal resection and reconstruction. Patients with laryngopharyngeal malignancies were treated with laryngopharyngectomy and the resulting defect was reconstructed with an anterolateral thigh flap. The study group consisted of 20 patients with one or more primary hypopharyngeal carcinomas or a relapse of this tumour. All patients were diagnosed and operated in the University Medical Center between February 2000 and July 2007. Data were collected from the clinical medical files of the departments of plastic surgery and oto-rhino-laryngology. The dietetic and speech therapy files were used as well. To study the quality of life, the Dutch version of the University of Washington Quality of Life questionnaire was sent to all surviving patients. The microsurgical reconstructions were 100% successful. Fifteen patients (75.0%) died during the follow-up period; the 5-year overall survival was 20%. Complications such as post-surgical fistulas and strictures requiring surgical intervention were found in five (25.0%) and six patients (30.0%), respectively. Other post-surgical complications such as wound dehiscence were seen in two patients (10.0%). The incidence of donor-site complications at the thigh was very low. No significant relationship was found among preoperative patients characteristics like age, gender, preoperative radiotherapy, the TNM (tumour, node, metastasis) classification of the tumour and the risk of post-surgical complications. The number and/or the severity of the complications were not significantly associated with the duration of surgery or ischaemia time. In our view, surgery is a good option in the treatment of these patients. Although curative treatment is the best outcome, a satisfactory palliation in itself can be a justification for this type of surgery. Although only seven patients were able to answer the QOL questionnaire, the positive judgements of these patients support this view point.

Contralateral reinnervation of midline muscles in nonidiopathic facial palsy.

Summary The purpose of this study was to analyze contralateral reinnervation of the facial nerve in eight patients with complete facial palsy after surgery or trauma and seven healthy volunteers. All patients had contralateral reinnervation of facial muscles as demonstrated by electrical nerve stimulation versus none of the control subjects. Four patients had facial muscle movements at the site of the damaged nerve. In one patient this was entirely the result of contralateral reinnervation, whereas the other three patients had innervation both ipsilaterally and contralaterally. This implies that renewed facial muscle activity should be examined considering the origin of the reinnervation, either contralateral or ipsilateral. Contralateral reinnervation is a common phenomenon after total facial palsy and can occur alongside ipsilateral reinnervation. It can be mistaken for adequate reinnervation of the damaged nerve, causing postponement of dynamic reconstruction therapy.