Eda Bengi Yilmaz

Malignant epitheloid angiomyolipoma of the kidney in a child treated with sunitinib, everolimus and axitinib

The malignant variant of epithelioid angiomyolipoma (EAML) of the kidney is uncommon, extremely aggressive and behaves like a renal cell carcinoma. We present a case of a 12-year-old male with malignant EAML who was treated according to adult treatment protocols. To our knowledge, axitinib has not been used before in children. We conclude that adult protocols, in this rare case, could be safely used in rare childhood malignancies.

Comparison of patient specific quality assurance tests done with using different dosimetric systems for intensity modulated radiotherapy treatment plans

Intensity modulated radiotherapy is the developed technique of 3 dimensional conformal radiation therapy. In this method, irradiated fields can be seperated into many subfields that are called segments. Each segmentsÂ’ radiation dose can be adjusted. Intensity modulated radiotherapy plans have complex segments and high gradient dose regions. Therefore, quality assurance of intensity modulated radiotherapy plans are very important. The aim of this study is to perform quality assurance tests of intensity modulated radiotherapy plans by using different dosimetric systems and compare of results. Intensity modulated radiotherapy treatment plans of thirty patientsÂ’ quality assurance were tested using Matrixx and Delta4. Then, gamma pass rates that were determined as a result of the gamma analysis done using gamma pass-fail criteria that had values of different dose difference and distance to agreement. In our study, the difference between the mean values of gamma pass rates determined before were statistically examined and there was significant difference between two dosimetric systems.

A Rare Cause of Abdominal Pain in Childhood: Cardiac Angiosarcoma

Cardiac angiosarcomas are extremely rare in childhood, they are rapidly progressive tumours that often present themselves as diagnostic dilemmas, resulting in delayed diagnosis. Also, extracardiac manifestations, including abdominal pain, are extremely rare in patients with intracardiac tumors. We herein present the case of a 15-year-old girl who presented with abdominal pain. Echocardiography and thoracic computed tomography showed right atrial mass. The patient underwent surgery, chemotherapy, and radiotherapy. Eight months after treatment, abdominal recurrence was detected. The abdominal mass was resected, and radiotherapy and new chemotherapy protocol were given. The present case illustrates a rare case of primary cardiac angiosarcoma posing a diagnostic dilemma in an adolescent girl.

Orbitaya Yayılım Gösteren Paranazal Sinüs Kökenli Alveolar Rabdomiyosarkom: Erişkin Bir Olgu

152 abdomiyosarkom (RMS), immatür mezenkimal hücrelerden köken alan, erken dönemde metastazlara yol açan malign bir yumuşak doku tümörüdür. RMS, çocukluk çağının en sık görülen primer orbital malign tümörü olup, ortalama tanı yaşı 6-8 yıldır.1 Tipik olarak hızlı büyüme gösteren, ağrısız ve çevre dokulara invaze olabilen kitle ile karakterize olup, erişkin hastalarda oldukça nadir izlenmektedir.1,2 Erişkin hastalarda nadir izlenmesine karşın prognozu daha kötüdür. Erişkinlerde baş-boyun yerleşimli RMS’de 5 yıllık sağkalım oranları %8’in altında iken, çocuklarda orbital RMS’de 10 yıllık sağkalım oranı %87 olarak bildirilmiştir.1,2 Orbitaya Yayılım Gösteren Paranazal Sinüs Kökenli Alveolar Rabdomiyosarkom: Erişkin Bir Olgu

Metachronuous Synovial Sarcoma After Treatment of Mixed Germ Cell Tumor in a Child of Complet Gonodal Dysgenesis

Patients with complete XY gonadal dysgenesis (GD) show a high predisposition to germ cell tumors (GCT). Patients with coexistence of GCT and GD have been reported previously. Here we present a 15-year-old girl with mixed GCT and GD who also developed an intra-abdominal synovial sarcoma one year after the treatment. This is the first report, to our knowledge, of synovial sarcoma associated with XY GD.

Orbital Metastasis of Multiple Myeloma: Case Report.

A 68-year-old woman with a history of multiple myeloma presented to the clinic with pain and vision loss in her right eye. Proptosis was observed in her right eye and eye movements were restricted in all directions. Best corrected visual acuity was 3/10 in her right eye. On biomicroscopic examination, hyperemia and subconjunctival hemorrhage were present. Fundus examination of the right eye revealed optic disc edema and choroidal folds. In magnetic resonance imaging two orbital masses were detected. Based on the patient’s history and ocular examination, we evaluated the masses as orbital metastasis of multiple myeloma. Palliative radiotherapy was recommended.

Pancreatic Involvement of Burkitt Lymphoma in a Child and Review of the Literature

Pancreatic involvement of non-Hodgkin lymphoma is extremely rare in childhood and can be overlooked in differential diagnosis of pancreatic masses. In this report we describe a 10-year-old boy who presented with pancreatitis and obstructive jaundice, which was the result of pancreatic involvement of Burkitt lymphoma.

Supernumerary Nipple Children with Different Types of Malignancies

A supernumerary nipple (SN), usually arises within the embryonic milk lines but can also occur in locations such as back, thigh, vulva and neck. The frequency of SN ranges from 0.2% to 5.6% depending on various factors. Although much has been written on the association of SN with other conditions, it still remains as a controversial and speculative area. SN can be associated with several disorders notably urological malformations and urogenital malignancies. To the our knowledge, the association of SN with childhood cancer has rarely been reported before.