Edith Labos

The autonomy of the orthographic pathway in a shallow language: Data from an aphasic patient

This paper reports the case of a Spanish monolingual aphasic patient, JD, who showed a severe impairment in language production. Overall, the patients difficulties were much more severe in oral than in written production. This study was an attempt to test whether writing without phonological mediation is possible in a shallow orthography such as Spanish. The results suggest that even in Spanish, despite its orthographic and phonological transparency, there are two writing routes, one based on the phonological representations of words and the other based on a direct access from semantic to the orthographic representations of words. The role played by each route seems to depend on the strategy used by the writer.

Presentation of ADAS cog test with delayed recall and semantic encoding during the learning phase: Results in normal, MCI and dementia population

OF LIFE IN PATIENTS WITH VERY MILD AND MILD AIZHEIMER’S DISEASE Anne Koivisto, Kristiina Hongisto (former Karttunen), Hilkka Soininen, Pertti Karppi, Asta Hiltunen, Tarja V€alim€aki, University of Eastern Finland, Kuopio, Finland; Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland; 3 Mikkeli Central Hospital, Mikkeli, Finland; Department of Neurology, North Carelia Central Hospital, Joensuu, Finland.

DIAGNOSTIC PERFORMANCE OF THE EXTENDED FUNCTIONAL STUDY (EFE) FOR COMPLEX ACTIVITIES OF DAILY LIVING IN PATIENTS WITH MILD COGNITIVE IMPAIRMENT (MCI) AND CONTROLS

memory complaints (MAC-Q 25). 17 were excluded from the study. Thus, the final sample consisted of 91 patients (14,28% with spontaneous complaints and 85,72% with inquired complaints). 26,37% were men and 73,63% were women (mean age 67,6 years; mean educational level of 4 for 8 years); 56% are married. 13,18% were alcoholics, 10,99% were smokers and 24,17% reported regular practice of physical activity. Themost common comorbidities were hypertension (69.23%), diabetes mellitus (36.26%), dyslipidemia (24.17%) hypothyroidism (21.97%), anxiety (17.58%) and depression (12,08%). After the neuropsychological tests, 24.2% of the patients were classified as subjective cognitive impairment, 38.5% as non-amnestic MCI, 7.7% as amnestic MCI and 29.7% as dementia. Patients with mild cognitive impairment or suspected dementia were referred to cranial tomography and evaluated individually. Conclusions:Subjective cognitive impairment is a frequent condition in primary care. Mild cognitive impairment and dementia are underdiagnosed. These data may be considered for the establishment of public health policies in underdeveloped countries.

FREQUENCY OF ANOSOGNOSIA AT DIAGNOSIS OF COGNITIVE IMPAIRMENT IS INFLUENCED BY COGNITIVE RESERVE

into 65-79 years and >80. The 65-79 years old age group were defined as Middle LOAD (MOAD) and the >80 years old group were defined as Late LOAD (LLOAD). Furthermore we aimed to investigate additional factors that may affect the rate of decline. Methods:The study used longitudinal data from the Essex Memory Clinic which included a total of 306 participants, 56 had YOAD and 249 LOAD (165 MOAD and 84 LLOAD). The rate of cognitive decline was measured using scores from theMini Mental State Examination (MMSE), and covariates included gender, years in education and vascular risk factors. The data were examined using multilevel modelling analysis. Results: At baseline, when comparing individuals with YOAD to LOAD, those with YOAD had lower MMSE scores at baseline (18.3) compared to those with LOAD (23.0; p<.001). The MOAD group had a baseline MMSE of 23.2 and the LLOADgroup 22.8 (ns). Beingmale, having better education and being diabetic were associated with higher baseline MMSE scores. The YOAD group deteriorated faster than the LOAD group (p<.001). The MOAD group declined faster than the LLOAD group despite having similar baseline MMSE scores. Conclusions: Patients with YOAD at the time of diagnosis deteriorated faster than those with LOAD. When age was split into three categories there was a gradual slowing of decline with increasing age. Of significance was that there was also a difference in the rate of decline between the MOAD and the LLOAD groups with the LLOAD group having a more benign disease course.

COGNITIVE RESERVE INDEX QUESTIONNAIRE (CRIQ) VERSUS YEARS OF FORMAL EDUCATION AS RISK FACTORS FOR COGNITIVE IMPAIRMENT

tients can be captured with a limited set of questions and categories. In addition, the data of a depressive group suggest a partially different complaint profile as compared to the MC-group. We work toward further refinement of the interview and coding glossary in order to derive a feasible clinical rating scale to elicit and quantify those SMC features (e.g. context information about memory problems, sense of progression over time) which are most closely associated with prodromal and preclinical Alzheimer’s disease.

RISK OF PROGRESSION TO DEMENTIA BASED ON MEMORY IMPAIRMENT SCREEN WITH DELAYED RECALL (MIS-D)

ON MEMORY IMPAIRMENT SCREEN WITH DELAYED RECALL (MIS-D) Marina Cavagna, Edith Labos, Mar ıa Florencia Grande, Daniel Bernardo Seinhart, Luis Camera, Marcelo Schapira, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; Universidad de Buenos Aires, Buenos Aires, Argentina; 3 Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. Contact e-mail: marina. cavagna@hospitalitaliano.org.ar

Development of dementia in a cohort of elderly who frequently use ambulatory health services

capabilities were used to accelerate study startup, facilitate intra-study amendments, and streamline shutdown activities.3. Outline opportunities for future improvement. Conclusions: The ADCS EDC system supports a collaborative design and specification process via an intuitive set of cloud-based spreadsheets which allow multi-disciplinary study teams to manage clinical trial databases without the need for IT staff, thus reducing unnecessary delays and potential errors due to miscommunication. This approach has been used to design and manage databases for more than 20 large, multi-site AD clinical trials as well as several extra-ADCS projects, such as the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and the Dominantly Inherited Alzheimer’s Network (DIAN).