Edith M. Parkhill

Papilloma of the larynx in children: A clinicopathologic study

P APILLOMA is the most common benign laryngeal neoplasm in children. Clinically laryngeal papilloma is a serious problem because of the location, the multiplicity of lesions, the persistent tendency to recurrence, and the resistance to treatment even though histologically it is a simple tumor. In children almost all papillomas are of the multiple recurring type. In the series of Holinger, Johnston and Anison [I], 81 per cent of the papillomas in children were multiple. The sex distribution shows a little tendency to favor male children [2,3]. Bjork and Weber [2] stated that new cases are becoming increasingly rare. They attribute this to improved social and hygienic conditions, although they observed more new cases during the second world war when conditions were at a low point. Cause of the disease is not known, but some evidence strongly suggests viral etiology [2,g or the operation has been done near the end of the time limit. The operator is likely to be misled into attributing a remarkable recovery to the particular method he happened to have used.” On the basis of an erroneous observation that most papihomas disappear or stop growing during puberty [23], hormonal factors were once thought to play a role in the treatment of the disease. Experience has shown this to be false. Electrocautery does not prevent relapses and overenthusiastic use causes excessive

Heterotopic bone in laparotomy scars.

Abstract Four patients with heterotopic bone in laparotomy scars have been seen recently at the Mayo Clinic. Three of the four were women, and, apparently, their cases are the first for women with this condition to be reported within the last forty-eight years. In two patients the heterotopic bone formed in the remarkable time of fourteen and eighteen days, respectively. It is suggested that the development of heterotopic bone in laparotomy scars frequently is caused by the implantation of either vesical or gastric mucosa into the wound at the time of operation.