Edward A. Partenope

The Hemodynamic Effects of Hypotensive Drugs in Man IV. 1-Hydrazinophthalazine

Further data are presented concerning the unusual hemodynamic effects of 1-hydrazinophthalazine. Previous observations demonstrating a marked increase in cardiac output in normotensive subjects are confirmed in hypertensive patients. The splanchnic vascular bed is one of the sites of increased blood flow. The similarity between the hemodynamic effects of 1-hydrazinophthalazine and pyrogens is pointed out and the pharmacologic basis for the clinically observed additive effects of 1-hydrazinophthalazine and hexamethonium is discussed.

A Clinical Appraisal of Pentapyrrolidinium (M&B 2050) in Hypertensive Patients

The new ganglionic blocking agent, pentapyrrolidinium or M&B 2050, appears to have several distinct advantages over hexamethonium in the treatment of severe hypertension. These advantages include longer duration of action, greater potency, less tolerance, less interference with intestinal motility, and, most important, a more uniform response from day to day on oral administration. However, critical adjustment of dosage is necessary and side effects are not infrequent, the most disturbing being postural faintness and impotence.

TRANSCAPILLARY MIGRATION OF HEAVY WATER AND THIOCYANATE ION IN THE PULMONARY CIRCULATION OF NORMAL SUBJECTS AND PATIENTS WITH CONGESTIVE HEART FAILURE

During recent years numerous investigations have been concerned with the rates of transfer or exchange of various substances across capillary beds (1-6). These studies, by analyzing curves of disappearance over several minutes from arterial plasma of intravenously injected tracer substances, have provided some information relative to all capillary beds combined. However, this type of experiment has not permitted a close analysis of the behavior of a substance during its first passage through a single organ capillary bed. Recently developed techniques (7-9) now permit the clinical investigator to examine the phenomena of transcapillary exchange of water and other diffusible substances in local vascular areas. This study was undertaken in an attempt to determine in vivo the diffusion characteristics of the pulmonary capillary bed in man with regard to deuterium oxide and an electrolyte, thiocyanate ion. Seven normal subjects and seven patients with pulmonary congestion due to heart failure were studied. The resulting data relating to the pulmonary capillaries were then compared to those previously obtained using similar tracer substances in the capillaries of the human forearm (7).

Clinical and Investigative Application of a New Instrument for Continuous Recording of Blood Pressure and Heart Rate

IN both routine hospital practice and clinical investigation, there has long been a need for an instrument that will continually record blood pressure and heart rate without discomfort to the patie...