Edward Carter
Harvard University
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Featured researches published by Edward Carter.
Surgery | 2011
Chuanan Shen; Shawn P. Fagan; Alan J. Fischman; Edward Carter; Jiake Chai; Xiao-Ming Lu; Yong-Ming Yu; Ronald G. Tompkins
BACKGROUND Hyperglycemia with insulin resistance is commonly seen in severely burned patients and tight glycemia control with insulin may be beneficial in this condition. The most potent insulinotropic hormone, glucagon-like peptide 1 (GLP-1), stimulates insulin secretion in a glucose-dependent manner. Because infusion of GLP-1 never reduces glucose levels to below ∼70 mg/dL, the risk of hypoglycemia by using insulin is reduced. In this study we investigated the metabolic effects of GLP-1 infusion after burn injury in an animal model. METHODS Male CD rats were divided in 3 groups: burn injury with saline, burn injury with GLP-1 treatment, and sham burn (SB). Burn injury was full thickness 40% total body surface area. The burn injury with GLP-1 treatment group received GLP-1 infusion via osmotic pump. Fasting blood glucose, plasma insulin, and plasma GLP-1 levels were measured during intraperitoneal glucose tolerance tests. Expressions of caspase 3 and bcl-2 were evaluated in pancreatic islets. In a subset of animals, protein metabolism and total energy expenditure were measured. RESULTS Fasting GLP-1 was reduced in burn injury with saline compared to SB or burn injury with GLP-1 treatment. Burn injury with GLP-1 treatment showed reduced fasting blood glucose, improved intraperitoneal glucose tolerance test results, with increased plasma insulin and GLP-1 responses to glucose. GLP-1 reduced protein breakdown and total energy expenditure in burn injury with GLP-1 treatment versus burn injury with saline, with improved protein balance. Increased expression of caspase 3 and decreased expression of bcl-2 in islet cells by burn injury were ameliorated by GLP-1. CONCLUSION Burn injury reduced plasma GLP-1 in association with insulin resistance. GLP-1 infusion improved glucose tolerance and showed anabolic effects on protein metabolism and reduced total energy expenditure after burn injury, possibly via insulinotropic and non insulinotropic mechanisms.
Society of Nuclear Medicine Annual Meeting Abstracts | 2011
Timothy Shoup; Edward Carter; Ali Bonab; Kasie Paul; Alan Fischman; David R. Elmaleh
Society of Nuclear Medicine Annual Meeting Abstracts | 2009
Edward Carter; Daniel Winter; Crystal Tolman; Ronald G. Tompkins; Alan Fischman
Society of Nuclear Medicine Annual Meeting Abstracts | 2011
Edward Carter; Victoria Hamrahi; Ali Bonab; Fiona Yull; Ronald G. Tompkins; Alan Fischman
Society of Nuclear Medicine Annual Meeting Abstracts | 2011
Edward Carter; David R. Elmaleh; Timothy Shoup; Ali Bonab; Kasie Paul; Ronald G. Tompkins; Alan Fischman
Society of Nuclear Medicine Annual Meeting Abstracts | 2011
Edward Carter; Timothy Shoup; David R. Elmaleh; Kasie Paul; Ali Bonab; Ronald G. Tompkins; Alan Fischman
Society of Nuclear Medicine Annual Meeting Abstracts | 2011
Edward Carter; Shawn P. Fagan; Victoria Hamrahi; Ali Bonab; Yong-Ming Yu; Joseph C. Wu; Walter Jung; Ronald G. Tompkins; Alan Fischman
Society of Nuclear Medicine Annual Meeting Abstracts | 2011
Edward Carter; Kasie Paul; Timothy Shoup; David R. Elmaleh; Ronald G. Tompkins; Alan Fischman
Society of Nuclear Medicine Annual Meeting Abstracts | 2011
Edward Carter; Victoria Hamrahi; Kasie Paul; Walter Jung; Sandra A. Barrow; Ali Bonab; Ronald G. Tompkins; Alan Fischman
Society of Nuclear Medicine Annual Meeting Abstracts | 2011
Edward Carter; John Benjamin; Victoria Hamrahi; Michael R. Hamblin; Jay A. Fishman; Ali Bonab; Ronald G. Tompkins; Alan Fischman