Edward Gomer Jones

A Study of Epidemiologic Factors in Carcinoma of the Uterine Cervix

The prevalence of cervical carcinoma in married and Gentile women has been found to occur. Factors possibly influencing the incidence include marriage before the age of 25 contraceptives lack of circumcision in the husband and poverty. Studies have indicated 2 possible reasons for excessive exposure: either poverty forces this association or some endogenous difference in hormone levels induces a greater a desire for early marriage and childbearing. A study was designed to determine the association of exogenous and endogenous factors with the disease and involved 429 controls over a 4-year period. Dietary deficiency estrogen excretion levels menstrual patterns hygienic practices contraceptives circumcision of marital and other partners and frequency and duration of coitus were examined; these it ems showed insignificant differences between the cases and their matched controls. Some evidence shows factors related to socioeconomic conditions and domestic and marital instability are more prominent in women who have carcinoma of the cervix than in comparable groups without the disease. The study has failed to disclose any new specific causative factors for cervical carcinoma. It does however reemphasize the importance of the socioeconomic complex of relative poverty where events such as rapid sexual development resulting in marriage intercourse and pregnancy occur significantly earlier in women destined to develop cervical carcinoma than in women without the disease.

Race and age at menarche

2 silk purse-string sutures were placed around its base. Then the cul-de-sac was obliterated by concentric sutures of 2-O silk beginning at the bottom of the cul-de-sac and proceeding upward (Moschowitza operation). The abdominal incision was then closed. The postoperative course was uncomplicated, and she was discharged five weeks after admission. Examination four years after repair shows no recurrence of the enterocele, and she is in good health.

Cancer detection during pregnancy: A progress report

Abstract The results of 5 years of cytodetection of cancer of the cervix during pregnancy in the Prenatal Clinics of the city and county of Los Angeles are presented. Abnormal cytology rates or each month of pregnancy and post partum are compared. Rates for different racial groups are shown. The accuracy of fluorescent staining is compared to the Papanicolaou staining method. The percentage of false negatives by the cervical scrape method is discussed. The tissue diagnoses and treatment of 988 patients are reported. The report includes prevalence rates for dysplasia and in situ carcinoma, the fate of 475 patients with dysplasia, and the treatment of 274 patients with in situ carcinoma, 14 patients with microinvasive carcinoma, and 18 patients with invasive disease.

CARCINOMA OF THE CERVIX UTERI DURING PREGNANCY. A STUDY OF THE COMBINED EFFECT OF A TRICHOMONACIDE, A BROAD-SPECTRUM ANTIBIOTIC, AND A LONG-ACTING PROGESTIN ON DYSPLASIA AND IN SITU CARCINOMA OF THE CERVIX.

Abstract 1. 1. An in vivo study has been started of patients with in situ carcinoma and dysplasia found during pregnancy to discern whether these lesions can be reversed by chemical substances. 2. 2. The first clinical trial with a trichomonacide given orally, a broad-spectrum antibiotic used vaginally, and a long-acting progesterone given intermuscularly (in sequential order) failed to produce regression in 50 per cent of cases within the time limit described. There was a suggestive change in some of the dysplasias. 3. 3. This group of cases demonstrates that the lesions found during pregnancy are similar to those found at other times and the majority persist if not treated or removed.

Polycystic ovaries and menstrual irregularities

Abstract 1. 1. Thirty-two cases of menometrorrhagia, 30 cases of secondary amenorrhea, and 7 instances of normally functioning ovaries have been reviewed. 2. 2. Laboratory investigations included studies of the pituitary, adrenal, and thyroid glands and the ovary. 3. 3. Biopsy of the ovary was obtained in each case by colpotomy and the gross and microscopic findings recorded. 4. 4. Attempts were made to correlate the symptom complex, laboratory and anatomical findings but were found unfruitful.