Edward J. Colwell

Serum immunoglobulin D and malaria antibodies in South Vietnamese residents

Abstract Serum immunoglobulin D concentrations were found to be elevated in Vietnamese and Montagnard but not in Cambodian residents of a Vietnam village which is highly endemic for malaria. Although a high frequency of positive malaria CF tests was demonstrated in all three groups, there was no significant correlation between the serum IgD levels and the malaria CF titres. Serum IgD levels in Vietnamese residents of a non-malarious community were similar to those of United States blood donors, however, in the former groups, a high frequency (i.e., 90%) of low titre CF reactions was observed, compared to a frequency of 8% low titre CF reactions in the U.S. donors.

Trichinella spiralis and Schistosoma mansoni: specificity of in vitro, leukocyte-mediated histamine release from rabbit platelets.

Abstract The specificity of the allergic release of histamine from rabbits infected with Trichinella spiralis or Schistosoma mansoni was examined using five different helminth antigens. Significant release could be demonstrated with homologous antigen in all 20 infected rabbits. Although several cross reactions in the infected animals were observed with non-Trichinella and Schistosoma antigens, the frequency of the cross reactions was considerably less than that observed in complement fixation or soluble antigen fluorescent antibody tests.

In vivo Passive Sensitization of Normal Rabbit Leukocytes with Sera Demonstrating Homocytotropic Antibody Activity

Normal rabbit leukocytes were passively sensitized, as determined by in vitro antigen-induced histamine release, by the i.v. administration of homologous sera demonstrating homocyto