Edward L. Burns

A study and classification of nodular lesions of the fallopian tubes

Abstract 1. 1. Three hundred and twenty-nine nodules in the walls of Fallopian tubes of two hundred and eight patients were studied. 2. 2. Eighty-one and seven-tenths per cent of the nodules were due to diverticula of tubal epithelium alone or in association with acute or chronic inflammatory lesions. We have suggested the term diverticulosis of the Fallopian tubes for these types of lesions. 3. 3. Eleven and two-tenths per cent of the nodules were due to inflammatory lesions without diverticulosis; six and seven-tenths per cent were due to endometriosis and three-tenths per cent were due to metastatic carcinoma of the endometrium.

Quantitative Studies on Relationship Between Estrogen and Mammary Gland Carcinoma in Strain C3H Mice

Summary 1. Beginning at the age of 2 weeks, 122 non-breeding male strain C3H mice were treated with estrogen for varying periods of time. At the end of the specified course of injections the mice received no further treatment until they died or were sacrificed. 2. Four weekly doses of 100 rat units of estrogen produced no mammary gland carcinomas; 8 and 12 weekly doses of 100 rat units produced a low incidence of these tumors. 3. After 16 weekly doses of 100 rat units of estrogen had been given a relatively high percentage of carcinoma of the mammary gland developed; the administration of 20 weekly doses or an average of 32.7 weekly doses of 100 rat units did not raise the incidence of tumors above this level. 4. Three thousand rat units of estrogen administered over a period of 3 days at the age of 2 weeks produced no tumors.

Occurrence of Urinary Calculi in Inbred Strain (C3H) of Mice Treated with Estrogen

Summary Urinary calculi occurred in 33.1% of the 151 strain C3H male mice treated with estogren, and in 4.1% of 96 controls. The highest incidence was noted in mice 5 months of age or older, which had received from 9 to 20 weekly injections of 100 rat units. The calculi appeared at an earlier age in the treated animals.

Use of Mice for Testing Toxicity of Rabbit Therapeutic Antipneumococcic Serum

Conclusion The intravenous injection of mice may prove to be a more satisfactory procedure than the methods now in use for testing the potential toxicity of rabbit antisera intended for human therapy.