Edward L. Paul

Handbook of Industrial Mixing

handbook of industrial mixing science and practice by. advances in industrial mixing a companion to the handbook. handbook of industrial mixing elusya de. handbook of industrial mixing wordpress com. handbook of industrial mixing science and practice with. handbook of industrial mixing joandisalovebooks com. handbook of industrial mixing science and practice with. handbook of industrial mixing science and practice. handbook of industrial mixing science and practice. handbook of industrial mixing science and practice. handbook of industrial mixing google books. handbook of industrial mixing science and practice. handbook of industrial mixing science and practice. pdf epub download handbook of industrial mixing science. pdf epub download handbook of industrial mixing ebook. “advances in industrial mixing a companion to the. solid–liquid mixing researchgate. handbook of industrial mixing overdrive. agitation and mixing of fluids cvut cz. advances in industrial mixing a companion to the handbook. 9780471269199 handbook of industrial mixing abebooks. handbook of industrial mixing. handbook of industrial mixing science and practice pdf. handbook of industrial mixing science and practice. handbook of industrial mixing science and pdf download. handbook of industrial mixing science and practice. handbook of industrial mixing science and practice by. advances in industrial mixing a companion to the handbook. handbook of industrial mixing science and practice book. books aiche the global home of chemical engineers. handbook of industrial mixing science and practice. “advances in industrial mixing a companion to the. handbook of industrial mixing free download ebooks. handbook of industrial mixing science and practice free. advances in industrial mixing a companion to the handbook. handbook of industrial mixing download ebook pdf epub. frontmatter handbook of industrial mixing wiley online. handbook of industrial mixing chemistry materials. advances in industrial mixing a companion to the handbook. amazon com handbook of industrial mixing science and. handbook of industrial mixing science and practice. handbook of industrial mixing science and practice. namf publications mixing

The effect of mixing on scaleup of a parallel reaction system

Abstract The study of the effect of mixing on parallel reactions can be effectively utilized to provide information on local micromixing as well as to define the mixing requirements for this important class of industrial applications. Parallel reactions can be either part of the inherent reaction system or can be encountered in neutralization of mixtures containing labile substrates. These effects must be considered in scale-up of reaction systems in which mixing sensitivity may be significant.

Design of Reaction Systems for Specialty Organic Chemicals

Abstract Design of reaction systems for specialty organic chemicals requires utilization of chemical reaction engineering principles for a wide variety of kinetic problems. Kinetic analysis must include breakdown of the overall reaction into definable components in order to identify parallel and/or consecutive reactions that result in by-product formation. Once identified, methods of minimizing by-product formation can be developed. Examples are described of complex reaction systems which have required development of specialized procedures to minimize by-product formation. Each example represents a different kinetic problem and method of solution. Emphasis is placed on the close interaction between chemists and chemical engineers during laboratory development and plant reaction system design to achieve successful commercial operation.

Design and Scaleup of an Anchorage‐dependent Mammalian Cell Bioreactor

In the early 1970s, work was initiated a t the Merck Sharp & Dohme Research Laboratories (MSDRL) on the design and scaleup of a bioreactor to produce viral vaccines using anchorage-dependent mammalian cells. The objective was to develop a bioreactor configuration meeting the requirements for growing such cells in tissue culture that could be successfully scaled for production operation in anticipation of increased developmental and manufacturing requirements that would greatly exceed the limited capacity of roller bottles. This work resulted in development of a successful system based on the use of Koch-Sulzer static mixing elements as cell growth surfaces. This paper describes the development of this system and includes data on its performance in cell growth and virus infection on two scales of operation.

AN INDUSTRIAL APPROACH TO INTEGRATED FERMENTATION/ISOLATION PROCESS DEVELOPMENT

This paper discusses some of the challenges that are presented in industrial development of isolation processes for fermentation products from broth. Those charged with maximizing fermentor output address themselves to a totally different set of parameters than those charged with purifying and separating the active component. However, the complexity and cost of the purification and separation operations are directly keyed to the final composition of the fermentation broth, thereby making the concept of integrated process development a practical necessity. This concept is far easier to state than to accomplish. Maximization of broth titer has, in many cases correctly, dominated fermentation development strategy. It is then necessary that the isolation process accommodate some degree of changes in broth composition. Furthermore, some of these changes may not be introduced until the process is on-stream in the manufacturing plant. There may be situations, however, in which a gain in broth titer results in a net loss in process economics and/or operability because of increased separation problems. Recognition of these interactions in both areas of development can lead to enhanced process optimization. Since the differences in professional discipline and interest do not usually have the “fermenter” and the “isolator” as the same person or even in the same organizational unit, an unusually high degree of mutual understanding and interaction is required for effective and rapid process development. A major tool to accomplish this goal is to have miniaturized fermentation and isolation equipment for quickly evaluating process changes (i.e., use testing) or, a t least, a method that more or less precisely characterizes the physical and chemical state of the harvested broth.