Edward Lewis Wilding

Electrophysiological evidence for dissociable processes contributing to recollection

This paper reviews a number of studies in which we have employed event-related potentials (ERPs) to investigate the cognitive processes which contribute to conscious recollection. Across a range of tasks (including recognition memory, source memory, associative recall and word-stem cued recall) there is evidence for the proposal that recollection involves processes which are both functionally and neurologically dissociable. This evidence takes the form of temporally and topographically dissociable ERP effects, which attain their maximum amplitude when elicited by items that satisfy operational definitions for having been recollected. The ERP effects are interpreted as reflecting retrieval and post-retrieval processes which, we argue, constitute two separate components of recollection as defined within the process dissociation framework of Jacoby and colleagues. The ERP findings suggest that post-retrieval processing is particularly sensitive to task variables, implying that recollection may be neither functionally nor neurologically homogeneous.

Event-related potentials and the recognition memory exclusion task

Subjects heard words that were presented in either a male or a female voice, and were required to perform one of two encoding tasks according to the gender of the voice. At test studied words were presented visually, along with a set of words new to the experiment. Subjects were required to respond on one key to words belonging to one of the two classes of studied word (targets), and to respond on a different key both to words belonging to the other study class (non-targets), and to words new to the experiment. In comparison to the event-related potentials (ERPs) elicited by new words, the ERPs elicited by correctly detected targets exhibited two temporally and topographically distinct positive going effects: one of these was phasic, showed a parietal maximum, and was larger over the left than the right hemisphere. The second effect was more sustained in time, frontally distributed, and was larger over the right hemisphere. The ERPs elicited by correctly classified non-targets contained the parietal effect only. These findings confirm that retrieval of contextual information in tests of recognition memory (recollection) is associated with two distinct ERP modulations. While one of these may be closely tied to process necessary for recollection, the other may reflect less obligatory processes which operate on the products of successful retrieval.

An event-related potential study of memory for words spoken aloud or heard.

Subjects made old/new recognition judgements to visually presented words, half of which had been encountered in a prior study phase. For each word judged old, subjects made a subsequent source judgement, indicating whether they had pronounced the word aloud at study (spoken words), or whether they had heard the word spoken to them (heard words). Event-related potentials (ERPs) were compared for three classes of test item; words correctly judged to be new (correct rejections), and spoken and heard words that were correctly assigned to source (spoken hit/hit and heard hit/hit response categories). Consistent with previous findings (Wilding, E. L. and Rugg, M. D., Brain, 1996, 119, 889-905), two temporally and topographically dissociable components, with parietal and frontal maxima respectively, differentiated the ERPs to the hit/hit and correct rejection response categories. In addition, there was some evidence that the frontally distributed component could be decomposed into two distinct components, only one of which differentiated the two classes of hit/hit ERPs. The findings suggest that at least three functionally and neurologically dissociable processes can contribute to successful recovery of source information.

The von Restorff Effect in Visual Object Recognition Memory in Humans and Monkeys: The Role of Frontal/Perirhinal Interaction

This study reports the development of a new, modified delayed matching to sample (DMS) visual recognition memory task that controls the relative novelty of test stimuli and can be used in human and nonhuman primates. We report findings from normal humans and unoperated monkeys, as well as three groups of operated monkeys. In the study phase of this modified paradigm, subjects studied lists of two-dimensional visual object stimuli. In the test phase each studied object was presented again, now paired with a new stimulus (a foil), and the subject had to choose the studied item. In some lists one study item (the novel or isolate item) and its associated foil differed from the others (the homogenous items) along one stimulus dimension (color). The critical experimental measure was the comparison of the visual object recognition error rates for isolate and homogenous test items. This task was initially administered to human subjects and unoperated monkeys. Error rates for both groups were reliably lower for isolate than for homogenous stimuli in the same list position (the von Restorff effect). The task was then administered to three groups of monkeys who had selective brain lesions. Monkeys with bilateral lesions of the amygdala and fornix, two structures that have been proposed to play a role in novelty and memory encoding, were similar to normal monkeys in their performance on this task. Two further groups with disconnection lesions of the perirhinal cortex and either the prefrontal cortex or the magnocellular mediodorsal thalamusshowed no evidence of a von Restorff effect. These findings are not consistent with previous proposals that the hippocampus and amygdala constitute a general novelty processing network. Instead, the results support an interaction between the perirhinal and frontal cortices in the processing of certain kinds of novel information that support visual object recognition memory.