Edward Shanbrom

HERPES ZOSTER IN HEMATOLOGIC NEOPLASIAS: SOME UNUSUAL MANIFESTATIONS

Excerpt While it is generally known that herpes zoster commonly appears in malignant diseases, the frequency with which it occurs in lymphomas and leukemias has received surprisingly little comment...

Critical evaluation of massive steroid therapy of acute leukemia.

THE fact that adrenocortical hormones can be of considerable benefit in acute leukemia has long been recognized. In recent years a number of investigators have attempted to enhance the effectivenes...

Evaluation of a New Concentrate for the Treatment of Factor IX Deficiency

Abstract A commercially prepared plasma concentrate was administered in six infusions to four patients with factor IX deficiency. All showed a distinct rise in the factor IX level. On the basis of the preliminary data a dose of 2 factor IX units per kilogram of body weight could be expected to produce a 1 percent rise in the factor IX level. Larger doses may be necessary in the actively bleeding patient. No serious side effects were observed. The increased factor IX concentration and the relatively low protein content of the material greatly reduces the possibility of precipitating circulatory overload while still achieving hemostatic factor IX levels.

Factor V: a Simplified One-Stage Assay using a Stabilized Artificial Substrate

Summary Alterations of factor V activity are now recognized in various clinical states and factor V levels are now suggested to be useful in the diagnosis of disseminated intravascular coagulation and primary hyperfibrinolytic syndromes. Available assay techniques, however, present many difficulties to be suitable for the clinical laboratory. A simple one-stage quantitative assay which utilizes the reagents of the standard prothrombin time and an easily prepared stable artificial substrate is here-in described. The assay is very reproducible, simple to perform, and is available for any clinical laboratory.

MULTIPLE HEMATOLOGIC ABNORMALITIES IN A CASE OF POSTNECROTIC CIRRHOSIS

Excerpt A great variety of hematologic disturbances may be associated with hepatocellular disease. There is no close correlation between the histopathology of the liver disease and the variety or d...

Clinical Evaluation of a New Intravenous Gamma Globulin.

Excerpt Existing intramuscular gamma globulin preparations cannot provide immediate replacement therapy by infusion of large doses. Previous attempts to produce an intravenous gamma globulin by aci...