Edward T. Howley

Limiting factors for maximum oxygen uptake and determinants of endurance performance.

In the exercising human, maximal oxygen uptake (VO2max) is limited by the ability of the cardiorespiratory system to deliver oxygen to the exercising muscles. This is shown by three major lines of evidence: 1) when oxygen delivery is altered (by blood doping, hypoxia, or beta-blockade), VO2max changes accordingly; 2) the increase in VO2max with training results primarily from an increase in maximal cardiac output (not an increase in the a-v O2 difference); and 3) when a small muscle mass is overperfused during exercise, it has an extremely high capacity for consuming oxygen. Thus, O2 delivery, not skeletal muscle O2 extraction, is viewed as the primary limiting factor for VO2max in exercising humans. Metabolic adaptations in skeletal muscle are, however, critical for improving submaximal endurance performance. Endurance training causes an increase in mitochondrial enzyme activities, which improves performance by enhancing fat oxidation and decreasing lactic acid accumulation at a given VO2. VO2max is an important variable that sets the upper limit for endurance performance (an athlete cannot operate above 100% VO2max, for extended periods). Running economy and fractional utilization of VO2max also affect endurance performance. The speed at lactate threshold (LT) integrates all three of these variables and is the best physiological predictor of distance running performance.

Criteria for maximal oxygen uptake : review and commentary

Historically, the achievement of maximal oxygen uptake (VO2max) has been based on objective criteria such as a leveling off of oxygen uptake with an increase in work rate, high levels of lactic acid in the blood in the minutes following the exercise test, elevated respiratory exchange ratio, and achievement of some percentage of an age-adjusted estimate of maximal heart rate. These criteria are reviewed relative to their history, the degree to which they have been achieved in published research, and how investigators and reviewers follow them in current practice. The majority of the criteria were based on discontinuous protocols, often carried out over several days. Questions are raised about the applicability of these criteria to modern continuous graded exercise test protocols, and our lack of consistency in the terminology we use relative to the measurement of maximal oxygen uptake.

Type of activity: resistance, aerobic and leisure versus occupational physical activity

PURPOSE To define and describe the essential terminology associated with dose-response issues in physical activity and health. METHODS Recent consensus documents, position stands, and reports were used to provide reference definitions and methods of classifying physical activity and exercise. RESULTS The two principal categories of physical activity are occupational physical activity (OPA) and leisure-time physical activity (LTPA). OPA is usually referenced to an 8-h d, whereas the duration of LTPA is quite variable. LTPA includes all forms of aerobic activities, structured endurance exercise programs, resistance-training programs, and sports. Energy expenditure associated with aerobic activity can be expressed in absolute terms (kJ x min(-1)), referenced to body mass (METs), or relative to some maximal physiological response (i.e., maximal heart rate (HR) or aerobic power (VO(2max))). The net cost of physical activity should be used to express energy expenditure relative to dose-response issues. The intensity of resistance training is presented in terms relative to the greatest weight that can be lifted one time in good form (1RM). The intensity of OPA followed the guidance of a previous consensus conference. The intensity of most LTPA can be categorized using the standard aerobic exercise classifications; however, for long-duration (2+ hours) LTPA, the classifications for OPA may be more appropriate. CONCLUSION Physical activities should be classified in a consistent and standardized manner in terms of both energy expenditure and the relative effort required.

Increasing daily walking lowers blood pressure in postmenopausal women

PURPOSE The American College of Sports Medicine and the Centers for Disease Control and Prevention (ACSM-CDC) recommend 30 min of daily moderate-intensity physical activity for health; however, the effectiveness of this recommendation in lowering blood pressure (BP) in hypertensives is unclear. The present study tested the hypothesis that walking activity following the ACSM-CDC physical activity recommendation would lower BP in postmenopausal women with high BP. METHODS Resting BP was measured in 24 postmenopausal women with borderline to stage 1 hypertension at baseline, 12 wk, and 24 wk. Fifteen women in the exercise (EX) group walked 3 km.d-1 above their daily lifestyle walking, whereas 9 women in the control (CON) group did not change their activity. Walking activity was self-measured with a pedometer in both groups. RESULTS Resting systolic BP was reduced in the EX group after 12 wk by 6 mm Hg (P < 0.005) and was further reduced by 5 mm Hg at the end of 24 wk (P < 0.005). There was no change in diastolic BP with walking. The CON group experienced no change in BP at either 12 or 24 wk. Body mass was modestly reduced by 1.3 kg in the EX group after 24 wk (P < 0.05); however, it was not correlated with the change in BP. There were no changes in selected variables known to impact BP including percent body fat, fasting plasma insulin, or dietary intake. CONCLUSION In conclusion, a 24-wk walking program meeting the ACSM-CDC physical activity recommendation is effective in lowering systolic BP in postmenopausal women with borderline to stage 1 hypertension.

Applicability of VO2max criteria : discontinuous versus continuous protocols

This study compared the classic discontinuous Taylor et al. (1955) protocol to a continuous version of the same protocol to evaluate maximal physiological responses, and the quantitative values and incidence of achievement of the various maximal oxygen uptake (VO2max) criteria in 10 males (24.1 +/- 2.5 yr). Criteria were a plateau in VO2 (change < 2.1 ml.kg-1.min-1), HR = age adjusted maximal, PER > or = 1.15, and lactate > 8 mmol.l-1. Values for VO2max (56.8 +/- 4.7 vs 55.8 +/- 4.2 ml.kg-1.min-1), ventilation (150.7 +/- 16 vs 149.5 +/- 17.5 l.min-1 BTPS), and HR (186.3 +/- 7.7 beats.min-1 vs 191.7 +/- 6.7 beats.min-1) were similar (P < 0.05) between the discontinuous protocol (DT) and the continuous protocol (CT), respectively. Values for RER (1.28 +/- 0.05 vs 1.22 +/- 0.05) and lactate (14.3 +/- 2.7 vs 11.9 +/- 2.7 mmol.l-1) were greater (P < 0.05) on the DT than the CT. Criteria achievement were the following: 40% (CT) and 10% (DT) for HR; 50% (CT) and 60% (DT) for a VO2 plateau; and, 90% (CT) and 100% (DT) for RER and lactate. It is concluded that a VO2 plateau is not a prerequisite for defining VO2max and is of limited use as the primary objective criterion for evaluating the quality of a graded exercise test. Therefore, the achievement of secondary objective criteria, specifically RER and lactate in combination, increases the likelihood that the highest VO2 value achieved is VO2max.

Oxygen cost of running in trained and untrained men and women.

The purpose of this study was to compare the oxygen cost of running as it relates to speed of running among the following four groups: trained male distance runners, trained female distance runners, untrained but active men and women. Each subject was given a series of treadmill tests during which Vo2 was measured at submaximal work loads. The linear regression equation was utilized to compute the relationship between Vo2 and running speed for each groups. The results indicated that the rate of increase in Vo2 for a given increase in running speed could be represented as a straight line and was the same for all groups (P greater than .05). The trained male runners had a significantly lower Vo2 (P less than .05) than those of the other three groups at any measured speed. The trained females and untrained males had significantly lower Vo2s than the untrained females (P less than .05) at any of the given range of speeds. No significant differences were observed between the untrained mean and trained women (P greater than .05). It was concluded that there were differences in the oxygen cost of running not only between the trained and untrained groups but also between males and females.

Swimming training lowers the resting blood pressure in individuals with hypertension

Background Despite the fact that swimming is often recommended for the prevention and treatment of hypertension, no study has examined the potential efficacy of regular swimming exercise for lowering the blood pressure in hypertensive humans. Objective To test the hypothesis that regular swimming exercise lowers the resting blood pressure. Design A 10-week closely supervised swimming training program compared with a non-exercising control group. Patients Eighteen previously sedentary men and women [aged 48 ± 2 years (mean ± SEM)] with stage 1 or 2 essential hypertension. Results The resting heart rate, an index of cardiovascular adaptation, decreased in the swimming training group from 81 ± 4 to 71 ± 3 beats/min (P < 0.01). The body mass and body fat percentage did not show statistically significant changes. The systolic blood pressure of patients in the seated position fell significantly (P < 0.05) from 150 ± 5 to 144 ± 4 mmHg. The seated diastolic blood pressure did not change significantly. A similar magnitude of reductions in systolic blood pressure (P < 0.05) was also found in patients in the supine position. No significant changes in plasma catecholamine concentrations, casual forearm vascular resistance, plasma volume and blood volume were observed. There were no significant changes in any of these variables in the control group. Conclusion Swimming training elicits significant reductions in arterial blood pressure at rest in individuals with hypertension. This is a clinically important finding since swimming can be a highly useful alternative to land-based exercises for hypertensive patients with obesity, exercise-induced asthma, or orthopedic injuries.

The Effects of Static Stretching and Warm-Up on Prevention of Delayed-Onset Muscle Soreness

It has been suggested in the lay literature that static stretching and/or warm-up will prevent the occurrence of Delayed-Onset Muscle Soreness (DOMS). The primary purpose of this study was to determine the effects of static stretching and/or warm-up on the level of pain associated with DOMS. Sixty-two healthy male and female volunteers were randomly assigned to four groups: (a) subjects who statically stretched the quadriceps muscle group before a step, (b) subjects who only performed a stepping warm-up, (c) subjects who both stretched and performed a stepping warm-up prior to a step test, and (d) subjects who only performed a step test. The step test (Asmussen, 1956) required subjects to do concentric work with their right leg and eccentric work with their left leg to voluntary exhaustion. Subjects rated their muscle soreness on a ratio scale from zero to six at 24-hour intervals for 5 days following the step test. A 4x2x2 ANOVA with repeated measures on legs and Duncans New Multiple Range post-hoc test found no difference in peak muscle soreness among the groups doing the step test or for gender (p greater than .05). There was the expected significant difference in peak muscle soreness between eccentrically and concentrically worked legs, with the eccentrically worked leg experiencing greater muscle soreness. We concluded that static stretching and/or warm-up does not prevent DOMS resulting from exhaustive exercise.

Variation in the aerobic demand of running among trained and untrained subjects.

Variation in the aerobic demand (VO2) of submaximal running was quantified among trained and untrained subjects stratified by performance capability. Based on a retrospective analysis of seven published studies, maximal aerobic power (VO2max), and submaximal VO2 values were analyzed in three groups of trained distance runners (Category 1 (C1) (elite runners; N = 22), Category 2 (C2) (sub-elite runners; N = 41), and Category 3 (C3) (good runners; N = 16), and one group (N = 10) of untrained subjects (Category 4; C4). Results indicated that VO2max differed significantly (P < 0.05) across groups, such that C1 > C2 > C3 > C4. Analysis of submaximal VO2 data also revealed that C4 was more uneconomical than C1, C2, and C3 and that C2 and C3 were less economical than C1. Average within-group variability in submaximal VO2 was similar across categories and a marked overlap of minimum, mean and maximal economy values existed across categories. These data suggest that 1) trained subjects are more economical than untrained subjects, 2) elite runners display better economy compared to less-talented counterparts, and 3) economical and uneconomical runners can be found in all performance categories.

Test of the Classic Model for Predicting Endurance Running Performance

PURPOSE To compare the classic physiological variables linked to endurance performance (VO2max, %VO2max at lactate threshold (LT), and running economy (RE)) with peak treadmill velocity (PTV) as predictors of performance in a 16-km time trial. METHODS Seventeen healthy, well-trained distance runners (10 males and 7 females) underwent laboratory testing to determine maximal oxygen uptake (VO2max), RE, percentage of maximal oxygen uptake at the LT (%VO2max at LT), running velocity at LT, and PTV. Velocity at VO2max (vVO2max) was calculated from RE and VO2max. Three stepwise regression models were used to determine the best predictors (classic vs treadmill performance protocols) for the 16-km running time trial. RESULTS Simple Pearson correlations of the variables with 16-km performance showed vVO2max to have the highest correlation (r = -0.972) and %VO2max at the LT the lowest (r = 0.136). The correlation coefficients for LT, VO2max, and PTV were very similar in magnitude (r = -0.903 to r = -0.892). When VO2max, %VO2max at LT, RE, and PTV were entered into SPSS stepwise analysis, VO2max explained 81.3% of the total variance, and RE accounted for an additional 10.7%. vVO2max was shown to be the best predictor of the 16-km performance, accounting for 94.4% of the total variance. The measured velocity at VO2max (PTV) was highly correlated with the estimated velocity at vVO2max (r = 0.8867). CONCLUSIONS Among well-trained subjects heterogeneous in VO2max and running performance, vVO2max is the best predictor of running performance because it integrates both maximal aerobic power and the economy of running. The PTV is linked to the same physiological variables that determine vVO2max.