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Dive into the research topics where Edwin W. Gould is active.

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Featured researches published by Edwin W. Gould.


American Journal of Clinical Pathology | 2011

Cystic Neutrophilic Granulomatous Mastitis An Underappreciated Pattern Strongly Associated With Gram- Positive Bacilli

Andrew A. Renshaw; Robert P. Derhagopian; Edwin W. Gould

Although granulomatous lobular mastitis is associated with gram-positive bacilli such as Corynebacterium, this association is not well known. We report 3 cases of mastitis caused by gram-positive bacilli. All 3 abscesses were suppurative with distinct enlarged cystic spaces in which rare gram-positive bacilli were identified. Two cases were also granulomatous. Cultures in all 3 cases were negative. All 3 patients recovered after biopsy and tetracycline-based therapy. Infection in the breast by gram-positive bacilli is associated with a distinct histologic pattern, including cystic spaces in the setting of neutrophilic/granulomatous inflammation that can be recognized and should prompt careful search for the organism within enlarged vacuoles.


International Journal of Infectious Diseases | 2013

Respiratory syncytial virus infection is strongly correlated with decreased mean platelet volume

Andrew A. Renshaw; Barbara Drago; Norma Toraya; Edwin W. Gould

BACKGROUND To date, infections have usually been associated with elevations of the mean platelet volume. We correlated infection with respiratory syncytial virus (RSV) with changes in mean platelet volume (MPV). METHODS A consecutive series of patients with positive and negative rapid RSV assays and viral cultures, as well as children under 10 years of age with bronchoscopy for pneumonia or airway obstruction, were compared. RESULTS The MPV was significantly lower in patients with positive versus negative rapid RSV assays (9.7±0.8 vs. 10.5±0.9 fl, p<0.001), as well as viral cultures (9.9±1.0 vs. 10.5±1.0 fl, p<0.001). Children with RSV undergoing bronchoscopy (n=7) also had significantly lower MPV than children without RSV (n=79) (8.8±1.0 vs. 10.2±1.1 fl, p<0.004). An MPV <8.9 fl had a sensitivity of 71% and specificity of 49% for RSV in children undergoing bronchoscopy. CONCLUSIONS We conclude that infection with RSV is associated with decreased MPV and this may be clinically useful in children undergoing bronchoscopy.


American Journal of Clinical Pathology | 2013

Thrombocytosis Is Associated With Mycobacterium tuberculosis Infection and Positive Acid-Fast Stains in Granulomas

Andrew A. Renshaw; Edwin W. Gould

Mycobacterium tuberculosis infection is associated with thrombocytosis. We sought to determine if this information might be valuable in evaluating granulomas using acid-fast stains (AFS). Fifty-eight patients with culture-confirmed M tuberculosis infection were compared with 75 patients with atypical mycobacterial infection and 48 patients negative for mycobacteria. Thrombocytosis (platelet count >360 × 10(3)/μL [360 × 10(9)/L]) was significantly more common in patients with M tuberculosis (50%) than those with either atypical mycobacterial infection (12%) or negative for mycobacteria (4%, P < .001 for each). In 67 patients, histologic evaluation of tissue samples showed granulomatous inflammation; 37 (55%) had positive AFS results. Of 19 patients with thrombocytosis, 16 (84%) had a positive AFS result compared with 21 (44%) of 48 without thrombocytosis (P = .003). Fifteen of 16 M tuberculosis cases with thrombocytosis had positive AFS findings on histologic evaluation; the single negative case had a platelet count of 362 × 10(3)/μL (362 × 10(9)/L). However, 3 of these cases of positive results on staining were initially diagnosed as negative and only recognized as positive on review. We conclude that patients whose specimens were sent for mycobacterial culture and thrombocytosis had an increased risk for M tuberculosis. Patients with granulomas and thrombocytosis are more likely to have a positive AFS result usually showing M tuberculosis. Finally, patients with initially negative AFS results and thrombocytosis deserve to have additional evaluation of the AFS specimens.


Cancer Cytopathology | 2015

Reducing indeterminate thyroid FNAs

Andrew A. Renshaw; Edwin W. Gould

The Bethesda System recommends limiting the percentage of cases diagnosed as indeterminate in thyroid fine‐needle aspirations (TFNAs). However, studies are lacking that document how to decrease the rate of indeterminate TFNAs and its effects.


Diagnostic Cytopathology | 2017

Incidence and significance of true papillae in thyroid fine needle aspiration

Andrew A. Renshaw; Edwin W. Gould

Whether true papillae without nuclear features of papillary carcinoma in thyroid fine needle aspirates should be diagnosed as atypia of undetermined significance (AUS) is unclear.


Diagnostic Cytopathology | 2018

Predominance of neutrophils in the cerebrospinal fluid of patients treated with intravenous immunoglobulin

Andrew A. Renshaw; Edwin W. Gould

Patients treated with intravenous immunoglobulin can present with numerous neutrophils in the cerebrospinal fluid.


Archives of Pathology & Laboratory Medicine | 2018

Improved Intraoperative Smears

Andrew A. Renshaw; Edwin W. Gould

the early FVM before the onset of classic diagnostic H&E signs. Also, it can upstage the FVM, as merely a single cluster of low-grade FVM with totally sclerotic villi may be only the tip of the iceberg and more hypovascular foci of high-grade FVM may be revealed by the double immunostain. Also, the double immunostain may be indicated when partially fibrotic chorionic villi (Figure, C), by themselves not diagnostic of FVM, are present and the development of villous hypovascularity would be just a matter of time (Figure, D). This is important as highgrade FVM is more likely to be associated with worse clinical outcome; however, brain calcified vascular microthrombi can be found on autopsy even in the incipient FVM diagnosed only on immunohistochemistry. Another histologic feature, commonly seen diffusely in postmortem placentas, is focal (lobular) mineralization (hemosiderosis, ferrugination) of chorionic villi, which may as well be seen in FVM early in nonsclerotic placentas (Figure, E through G), but may persist and be revealed by iron histochemistry stain even in totally sclerotic placentas (Figure, H). In summary, to diagnose histologically unapparent—on H&E—but otherwise likely FVM, double E cadherin/ CD34 immunostain and iron histochemistry stain could be used. This would increase the sensitivity of placental examination in diagnosing and/ or upstaging FVM in not-yet-sclerotic or diffusely sclerotic chorionic villi.


Pathology | 2016

OCT4 staining increases the detection of lymphatic/vascular invasion in pure seminoma of the testis obscured by prominent lymphohistiocytic inflammation.

Andrew A. Renshaw; Edwin W. Gould

Lymphatic/vascular invasion (LVI) is an important prognostic feature in pure seminoma of the testis, a tumour that may be associated with lymphohistiocytic inflammation (LHI). Traditionally, LVI is identified on routine haematoxylin and eosin (H&E) staining. We sought to determine if staining of LHI near vessels in cases of pure seminoma with OCT4 could improve detection of LVI. All available cases of pure seminoma of the testis at our institutions were reviewed and correlated with clinicopathological features. A total of 67 cases were reviewed. Traditional LVI was identified in five cases by routine H&E evaluation. LHI was associated with identifiable vessels in 13 cases. In six of these cases, neoplastic cells were identified in the lumen of vessels by H&E staining. In five additional cases, OCT4 identified neoplastic cells in the lumen of vessels. Two foci did not have neoplastic cells identified. Patients with LVI had larger tumours, were less often limited to the testicular parenchyma (other than the LVI), and more often had metastatic disease than patients without LVI. Traditional LVI was found most often in the testis, while LVI with LHI was found most often in the spermatic cord. LVI in the spermatic cord of patients with pure seminoma may be obscured by prominent LHI, and staining of such foci with OCT4 may increase the detection of LVI by 45%.


Cancer Cytopathology | 2013

The addition of RPMI significantly improves the cellularity of cerebrospinal fluid cytology specimens over time.

Scott A. Renshaw; Suresh Gupta; Michael Campos; Lori Hodes; Andrew A. Renshaw; Edwin W. Gould

Cytology specimens of cerebrospinal fluid (CSF) may be hypocellular, and the cells in CSF specimens degrade rapidly.


Cancer Cytopathology | 2016

Impact of specific patterns on the sensitivity for follicular and Hurthle cell carcinoma in thyroid fine‐needle aspiration

Andrew A. Renshaw; Edwin W. Gould

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Andrew A. Renshaw

Baptist Memorial Hospital-Memphis

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Lori Hodes

Baptist Memorial Hospital-Memphis

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Michael Campos

Baptist Memorial Hospital-Memphis

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Ming Jin

The Ohio State University Wexner Medical Center

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Norma Toraya

Baptist Memorial Hospital-Memphis

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Paul E. Wakely

The Ohio State University Wexner Medical Center

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Robert P. Derhagopian

Baptist Memorial Hospital-Memphis

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Scott A. Renshaw

Baptist Memorial Hospital-Memphis

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Suresh Gupta

Baptist Memorial Hospital-Memphis

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