Eiko Mushimoto

Effectiveness of Absorbable Electrified Poly-L-lactic Acid Membrane for Bone Regeneration in Rats.

目的: 本研究は, 生体吸収性で圧電性を有するポリ乳酸膜 (poly-L-lactic acid, 以下, PLLA) を用いた骨誘導再生法が人工的骨欠損部の再生に及ぼす効果を病理組織学的に検索し, Gore-Tex Augmentation material (GTAM®) および圧電性を有しないポリ乳酸膜 (polylactic acid, 以下, PLA) の効果と比較検討することを目的とした.方法: 実験には, 生後13～15週齢のWistar系雄性ラットを使用し, 直径2.0mmの骨窩洞を右大腿骨に形成した. 骨窩洞は, 実験A群ではGTAM®, B群では圧電性を有しないPLA, C群では圧電性を有するPLLA (分子量10万), D群では圧電性を有するPLLA (分子量30万) で被覆して囲続結紮した後, 軟組織で覆い縫合した. 実験期間は2週, 4週とし, 屠殺後, 硬組織研磨標本により病理組織学的観察を行った.結果: C, D群はA群に比較して早期より骨形成と成熟化が促進されていた. 特に, D群で新生骨の形成が窩洞全体に著明にみられ皮質骨全体の厚みを増し, 成熟度も高く, 既存皮質骨と同化していた. A群の骨再生はB群と同程度であり, 各実験期間でC, D群より劣っていた. またPLLAは皮質骨の上に望ましい形態を得るための賦形性に優れていた.結論: PLLAはGTAM®に比較して骨再生促進効果に優れ, 骨誘導再生法により有用であることが示された.

Sex Differences in Association between Oral Health and Cardiovascular Disease.

Recent epidemiological studies have found an association between general health status such as CHD and oral health condition, particularly in people with evidence of Chlamydia pneumoniae infection. However, there is conflicting data for the relationship between CHD and the oral condition.The purpose of this study was to understand the relationship between oral health such as caries, periodontal disease and cardiovascular disease in relation to sex differences.Oral and microbiological examinations were conducted on 106 patients aged 50 years and over (68 males, 38 females) with cardiovascular disease, admitted to Iwate Medical University Hospital. In this study, the subjects were divided into two groups, male and female.The conclusions were as follows:1. Characteristic results of microbiological examination showed no significant relationship between people with cardiovascural disease.2. As for hard tissue, previous treatment of coronal caries was higher in females than males, and morbidity of root caries was higher in males than in females.3. Morbidity of periodontal disease was higher in people with cardiovascural disease than in normal people, and in sex differences, oral health of males was worse than females.

Improved Occlusal Relationship by Prosthodontic Treatment in a Patient of Severe Anterior Open Bite with Rheumatoid Arthritis: Report of Case.

A prosthodontic treatment of a 39-year-old female who had severe anterior open bite with rheumatoid arthritis was reported. Rheumatoid arthritis had been diagnosed 5 years previously, and she had been hospitalized for infection of the spine, shoulder and knee joints. In her medical history, the patient stated that her mandible had continued to gradually retrude for the past 3 years, resulting in severe anterior open bite.Because of the progressive nature of rheumatoid arthritis, the decision was made to perform a reversible procedure to apply a prosthesis made of acrylic resin for stable occlusal contact with a posterior tooth. Afterthe eighth month, even distribution of posterior tooth contact was acquired with decreased vertical overbiteof 1 mm. After maxillary anterior prosthesis made of acrylic resin were provided with suitable verticaloverbite and anterior guidance, the metal prosthesis were provided at fourteen months after the first examination.In this report, it was suggested that occlusal management could improve anterior open bite caused byrheumatoid arthritis of TMJ, however, lateral transcranial radiography of TMJ findings still showed deformityand flattening of the condyle and the articular eminence of bilateral TMJ after treatment.