Eizo Okamoto

Current Status of Hepatic Resection in the Treatment of Hepatocellular Carcinoma

Most patients suffering from hepatocellular carcinoma (HCC) in Japan have associated liver cirrhosis or a related liver disease. In the past, massive hepatic resection in these patients applied to cure the HCC frequently resulted in a fatal liver failure postoperatively. Preoperative assessment to determine a safe limit for resection is the most urgent problem for liver surgeons in Japan [1].

Increase in muscarinic acetylcholine receptors in mouse intestine by hexamethonium treatment

The effects of hexamethonium (C6) administration on muscarinic acetylcholine receptors (mACh-R) in the intestine and brain of mice were investigated. Mice were treated with C6 with an osmotic mini-pump (330 mg/kg/day) for one week and then the binding of 3H-quinuclidinylbenzilate (3H-QNB) in the intestine and brain were assayed. This treatment increased the maximum specific binding (Bmax) of 3H-QNB from 160 to 320 fmoles/mg protein in the ileum and from 190 to 340 fmoles/mg protein in the rectum, without affecting the KD values in these regions. On the contrary, C6 treatment did not change the Bmax or KD value in brain tissues. This C6 treatment increased the sensitivity of the contractile response of the intestine to muscarinic agonists, possibly by increasing mACh-R.

Nonmechanical intestinal obstruction simulating surgical emergency in the newborn infant

Abstract Newborns who would have ultimately died with intestinal obstruction of unknown etiology but in which the causal condition was clarified by extensive laboratory tests and needless surgery avoided are presented. These are sepsis, adrenal insufficiency, hypothyroidism, lactose intolerance, and fetomaternal transfusion.

Fibroma of the kidney in the newborn

Abstract A large fibroma of the kidney, successfully removed by surgery, in a newborn is reported with a bibliography pertinent to 33 previously recorded cases of which 4 were children.

Some Problems in Estimating ICGRmax and Its Clinical Significance.

慢性肝疾患405例を対象とし, Rmax測定上の問題点と対策およびRmaxの意義について検討した.Rmax算出上の基本条件である不等式 (K1>K2>K3) 不成立の頻度は前期 (1976～1983.3, K0.5, K1.0, K3.0) では46% (92/201) であったが, Rmax測定法を改良した後期 (1983.3～1987.12, K0.5, K2.0, K4.0) では14% (28/204) に減じた.不等式を満足する評価可能例のRmaxは例外なく5mg/kg/min未満であった.不等式不成立例にはKICGが0.05min-1未満, あるいは0.15min-1以上を示す肝予備能の高度障害例あるいは良好例が多かった.Rmaxが最も強い相関を示したのは肝線維率であり, 0.47mg/kg/min以下の症例は例外なくB型肝硬変例であった.KICGに比べRmaxが相対的に低値を示す解離例は肝硬変の進行例が多く, また食道静脈瘤合併率が高かった.

Experimental study on hemorrhage in the brain stem induced by an intracranial space occupying lesion

Increased intracranial pressure was experimentally produced in dogs by inserting a rubber balloon epidurally in the left temporal region and then inflating the balloon with water. The animals were killed after a set interval and the hemorrhagic lesion in the brain stem examined in detail.