Elaine Burland

Are cervical cancer screening rates different for women with schizophrenia? A Manitoba population-based study

CONTEXT Barriers to cervical cancer screening (Pap tests) may exist for women experiencing schizophrenia. DESIGN This study analyzed healthcare records of all women in the province of Manitoba, Canada to: (a) compare cervical cancer screening rates of women with and without schizophrenia; and (b) determine factors associated with screening uptake. SETTING This study took place in Manitoba, Canada, utilizing anonymized universal administrative data in the Population Health Research Data Repository at the Manitoba Centre for Health Policy. PARTICIPANTS All females aged 18-69 living in Manitoba December 31, 2002, excluding those diagnosed with invasive or in situ cervical cancer in the study period or previous 5 years. MAIN OUTCOME To determine factors associated with Papanicolaou (Pap) test uptake (1+ Pap test in 3 years, 2001/02-2003/04), logistic regression modeling included: diagnosis of schizophrenia, age, region, average household income, continuity of care (COC), presence of major physical comorbidity. Good COC was defined as at least 50% of ambulatory physician visits from the same general/family practitioner within two years. RESULTS Women with schizophrenia (n=3220) were less likely to have a Pap test (58.8% vs. 67.8%, p<.0001) compared to all other women (n=335 294). In the logistic regression, a diagnosis of schizophrenia (aOR=0.70, 95% CI 0.65-0.75); aged 50+, and living in a low-income area or the North decreased likelihood; good continuity of care (aOR 1.88, 95% CI 1.85-1.91) and greater physical comorbidity (1.21, 95% CI 1.04-1.41) increased likelihood. CONCLUSION Women with schizophrenia are less likely to receive appropriate cervical cancer screening. Since good continuity of care by primary care physicians may mitigate this, psychiatrists should consider assisting in ensuring screening uptake.

Does a diagnosis of schizophrenia reduce rates of mammography screening? A Manitoba population-based study

1. IntroductionIt is estimated that mammography screening can reducemortality from breast cancer by 20 –35% for women aged 50 to69years,and20%forwomenaged40through49years( Elmoreetal.;2005;FletcherandElmore2003 ).Forwomenaged50 –69,theCanadian Task Force on the Periodic Health Examination (nowknownastheCanadianTaskForceonPreventiveHealthCare)andthe U.S. Preventive Services Task Force recommend mammo-graphyscreeningevery1 –2years(deGrasseetal.,1999;Ferrinietal.,1996; Ringash and Canadian Task Force on Preventive HealthCare, 2001; US Preventive Services Task Force 2002 ). ManitobasBreastScreeningProgramstatesthatthebestchancesofreducingdeaths from breast cancer arise from screening at least 70% ofManitoba women aged 50 through 69 every two years.According to the Statistics Canada Canadian CommunityHealth Survey [CCHS] 3.1 (Statistics Canada 2005) 72.6% ofwomen aged 50 through 69 years received a mammogram(screening or diagnostic) over a two-year period. Women inManitoba self-reported much lower rates, at 65.6%, with 42.6%

Data Resource Profile: Pathways to Health and Social Equity for Children (PATHS Equity for Children)

The PATHS Data Resource is a unique database comprising data that follow individuals from the prenatal period to adulthood. The PATHS Resource was developed for conducting longitudinal epidemiological research into child health and health equity. It contains individual-level data on health, socioeconomic status, social services and education. Individuals’ data are linkable across these domains, allowing researchers to follow children through childhood and across a variety of sectors. PATHS includes nearly all individuals that were born between 1984 and 2012 and registered with Manitoba’s universal health insurance programme at some point during childhood. All PATHS data are anonymized. Key concepts, definitions and algorithms necessary to work with the PATHS Resource are freely accessible online and an interactive forum is available to new researchers working with these data. The PATHS Resource is one of the richest and most complete databases assembled for conducting longitudinal epidemiological research, incorporating many variables that address the social determinants of health and health equity. Interested researchers are encouraged to contact [mchp_access@cpe.umanitoba.ca] to obtain access to PATHS to use in their own programmes of research.

The Effect of Neighborhood Socioeconomic Status on Education and Health Outcomes for Children Living in Social Housing

OBJECTIVES We explored differences in health and education outcomes between children living in social housing and not, and effects of social housings neighborhood socioeconomic status. METHODS In this cohort study, we used the population-based repository of administrative data at the Manitoba Centre for Health Policy. We included children aged 0 to 19 years in Winnipeg, Manitoba, in fiscal years 2006-2007 to 2008-2009 (n = 13,238 social housing; n = 174,017 others). We examined 5 outcomes: age-2 complete immunization, a school-readiness measure, adolescent pregnancy (ages 15-19 years), grade-9 completion, and high-school completion. Logistic regression and generalized estimating equation modeling generated rates. We derived neighborhood income quintiles (Q1 lowest, Q5 highest) from average household income census data. RESULTS Children in social housing fared worse than comparative children within each neighborhood income quintile. When we compared children in social housing by quintile, preschool indicators (immunization and school readiness) were similar, but adolescent outcomes (grade-9 and high-school completion, adolescent pregnancy) were better in Q3 to Q5. CONCLUSIONS Children in social housing had poorer health and education outcomes than all others, but living in social housing in wealthier areas was associated with better adolescent outcomes.

Unconditional Prenatal Income Supplement and Birth Outcomes.

BACKGROUND AND OBJECTIVES: Perinatal outcomes have improved in developed countries but remain poor for disadvantaged populations. We examined whether an unconditional income supplement to low-income pregnant women was associated with improved birth outcomes. METHODS: This study included all mother–newborn pairs (2003–2010) in Manitoba, Canada, where the mother received prenatal social assistance, the infant was born in the hospital, and the pair had a risk screen (N = 14 591). Low-income women who received the income supplement (Healthy Baby Prenatal Benefit [HBPB], n = 10 738) were compared with low-income women who did not receive HBPB (n = 3853) on the following factors: low birth weight, preterm, small and large for gestational age, Apgar score, breastfeeding initiation, neonatal readmission, and newborn hospital length of stay (LOS). Covariates from risk screens were used to develop propensity scores and to balance differences between groups in regression models; γ sensitivity analyses were conducted to assess sensitivity to unmeasured confounding. Population-attributable and preventable fractions were calculated. RESULTS: HBPB was associated with reductions in low birth weight (aRR, 0.71 [95% CI, 0.63–0.81]), preterm births (aRR, 0.76 [95% CI, 0.69–0.84]) and small for gestational age births (aRR, 0.90 [95% CI, 0.81–0.99]) and increases in breastfeeding (aRR, 1.06 [95% CI, 1.03–1.09]) and large for gestational age births (aRR, 1.13 [95% CI, 1.05–1.23]). For vaginal births, HBPB was associated with shortened LOS (weighted mean, 2.86; P < .0001). Results for breastfeeding, low birth weight, preterm birth, and LOS were robust to unmeasured confounding. Reductions of 21% (95% CI, 13.6–28.3) for low birth weight births and 17.5% (95% CI, 11.2–23.8) for preterm births were associated with HBPB. CONCLUSIONS: Receipt of an unconditional prenatal income supplement was associated with positive outcomes. Placing conditions on income supplements may not be necessary to promote prenatal and perinatal health.

Have We Left Some Behind? Trends in Socio-Economic Inequalities in Breastfeeding Initiation: A Population-Based Epidemiological Surveillance Study

OBJECTIVES: Breastfeeding is associated with improved health. Surveillance data show that breastfeeding initiation rates have increased; however, limited work has examined trends in socio-economic inequalities in initiation. The study’s research question was whether socio-economic inequalities in breastfeeding initiation have changed over the past 20 years.METHODS: This population-based study is a project within PATHS Equity for Children. Analyses used hospital discharge data for Manitoba mother–infant dyads with live births, 1988-2011 (n=316,027). Income quintiles were created, each with ≈20% of dyads. Three-year, overall and by-quintile breastfeeding initiation rates were estimated for Manitoba and two hospitals. Age-adjusted rates were estimated for Manitoba. Rates were modelled using generalized linear models. Three measures, rate ratios (RRs), rate differences (RDs) and concentration indices, assessed inequality at each time point. We also compared concentration indices with Gini coefficients to assess breastfeeding inequality vis-à-vis income inequality. Trend analyses tested for changes over time.RESULTS: Manitoba and Hospital A initiation rates increased; Hospital B rates did not change. Significant inequalities existed in nearly every period, across all three measures: RRs, RDs and concentration indices. RRs and concentration indices suggested little to no change in inequality from 1988 to 2011. RDs for Manitoba (comparing initiation in the highest to lowest income quintiles) did not change significantly over time. RDs decreased for Hospital A, suggesting decreasing socio-economic inequalities in breastfeeding; RDs increased for Hospital B. Income inequality increased significantly in Manitoba during the study period.CONCLUSIONS: Overall breastfeeding initiation rates can improve while inequality persists or worsens.RésuméOBJECTIFS : L’allaitement est associé à une meilleure santé. Selon les données de surveillance, les taux d’initiation de l’allaitement maternel augmentent, mais peu d’études examinent les tendances des inégalités socioéconomiques dans l’initiation de l’allaitement. Notre question de recherche était de savoir si les inégalités socioéconomiques dans l’initiation de l’allaitement maternel ont changé au cours des 20 dernières années.MÉTHODE : Cette étude populationnelle s’inscrit dans le programme PATHS Equity for Children. Nos analyses ont utilisé les données de sortie d’hôpital du Manitoba pour les dyades mère-nourrisson avec naissances vivantes de 1988 à 2011 (n=316 027). Des quintiles de revenu ont été créés, contenant chacun ≈20 % des dyades. Les taux d’initiation de l’allaitement maternel sur trois ans, globaux et par quintile, ont été estimés pour l’ensemble du Manitoba et pour deux hôpitaux. Des taux ajustés selon l’âge ont été estimés pour le Manitoba. Les taux ont été modélisés à l’aide de modèles linéaires généralisés. Trois indicateurs, les ratios des taux (RT), les différences de taux (DT) et les indices de concentration, ont permis d’évaluer l’inégalité à chaque point dans le temps. Nous avons aussi comparé les indices de concentration aux coefficients de Gini pour évaluer l’inégalité dans l’allaitement par rapport à l’inégalité des revenus. Des analyses des tendances ont servi à déceler les changements au fil du temps.RÉSULTATS : Les taux d’initiation du Manitoba et de l’hôpital A ont augmenté; les taux de l’hôpital B n’ont pas changé. Des inégalités significatives étaient présentes dans pratiquement toutes les périodes et pour les trois indicateurs: RT, DT et indices de concentration. Les RT et les indices de concentration ont fait état de changements faibles ou nuls dans l’inégalité de 1988 à 2011. Les DT pour le Manitoba (comparant l’initiation du quintile de revenu supérieur au quintile inférieur) n’ont pas significativement changé au fil du temps. Les DT ont diminué pour l’hôpital A, ce qui pourrait signaler une baisse des inégalités socioéconomiques dans l’allaitement; les DT ont augmenté pour l’hôpital B. L’inégalité des revenus a significativement augmenté au Manitoba sur la période de l’étude.CONCLUSIONS : Les taux d’initiation de l’allaitement maternel peuvent s’améliorer globalement alors que l’inégalité subsiste ou s’aggrave.

Long-Term Benefits of Full-Day Kindergarten: A Longitudinal Population-Based Study

In the first longitudinal, population-based study of full-day kindergarten (FDK) outcomes beyond primary school in Canada, we used linked administrative data to follow 15 kindergarten cohorts (n ranging from 112 to 736) up to grade 9. Provincial assessments conducted in grades 3, 7, and 8 and course marks and credits earned in grade 9 were compared between FDK and half-day kindergarten (HDK) students in both targeted and universal FDK programmes. Propensity score matched cohort and stepped-wedge designs allowed for stronger causal inferences than previous research on FDK. We found limited long-term benefits of FDK, specific to the type of programme, outcomes examined, and subpopulations. FDK programmes targeted at low-income areas showed long-term improvements in numeracy for lower income girls. Our results suggest that expectations for wide-ranging long-term academic benefits of FDK are unwarranted.

A Systematic Review of the Effect of Early Interventions for Psychosis on the Usage of Inpatient Services

Objectives: To review and synthesize the currently available research on whether early intervention for psychosis programs reduce the use of inpatient services. Methods: A systematic review was conducted using keywords searches on PubMed, Embase (Ovid), PsycINFO (ProQuest), Scopus, CINAHL (EBSCO), Social Work Abstracts (EBSCO), Social Science Citations Index (Web of Science), Sociological Abstracts (ProQuest), and Child Development & Adolescent Studies (EBSCO). To be included, studies had to be peer-reviewed publications in English, examining early intervention programs using a variant of assertive community treatment, with a control/comparison group, and reporting inpatient service use outcomes. The primary outcome extracted number hospitalized and total N. Secondary outcome extracted means and standard deviations. Data were pooled using random effects models. Primary outcome was the occurrence of any hospitalization during treatment. A secondary outcome was the average bed-days used during treatment period. Results: Fifteen projects were identified and included in the study. Results of meta-analysis supported the occurrence of a positive effect for intervention for both outcome measures (any hospitalization OR: 0.33; 95% CI 0.18–0.63, bed-days usage SMD: −0.38, 95% CI −0.53 to −0.24). There was significant heterogeneity of effect across the studies. This heterogeneity is due to a handful of studies with unusually positive responses. Conclusion: These results suggest that early intervention programs are superior to standard of care, with respect to reducing inpatient service usage. Wider use of these programs may prevent the occurrence of admission for patients experiencing the onset of psychotic symptoms.

An early intervention for psychosis and its effect on criminal accusations and suicidal behaviour using a matched-cohort design ☆ ☆☆ ★

BACKGROUND Early interventions for psychosis have been shown to reduce psychotic symptoms and hospital use for first-episode patients, but the effect on suicidal and criminal behaviour has not been reliably determined. This study aimed to examine whether an early intervention for psychosis program (EPPIS) reduced criminal behaviour, suicide attempts, and hospital-based service use. METHODS The study utilized administrative data to match clients of EPPIS to historical controls. Regression was used to determine the effect of treatment by EPPIS on inpatient use, emergency department use, suicide attempts/deaths, and criminal accusations. RESULTS A sample of 244 patients was matched to 449 controls. EPPIS patients had lower odds of being accused of a crime both during and after treatment. Suicidal behavior was less frequent among patients, both during treatment (p<0.0001) and after (HR=0.39; 95% CI: 0.17 to 0.94). During treatment there were more emergency department visits for the patients (RR=2.54; 95% CI: 1.56 to 4.58), but no difference in inpatient usage compared to controls. Post-treatment, both emergency department and inpatient usage were higher among patients. CONCLUSIONS EPPIS patients had reduced suicide attempts and criminal accusations. Increased emergency department use could indicate that encouraging treatment during a crisis may increase service use, while reducing suicidal and criminal behaviour.

An Unconditional Prenatal Income Supplement Reduces Population Inequities In Birth Outcomes

The Commission on Social Determinants of Health, sponsored by the World Health Organization, has identified measuring health inequities and evaluating interventions to reduce them as important priorities. We examined whether an unconditional prenatal income supplement for low-income women was associated with reduced population-level inequities in birth outcomes. We identified all mother-newborn pairs from the period 2003-10 in Manitoba, Canada, and divided them into the following three groups: low income exposed (received the supplement); low income unexposed (did not receive the supplement); and not low income unexposed (ineligible for the supplement). We measured inequities in low-birthweight births, preterm births, and breast-feeding initiation among these groups. The findings indicated that the socioeconomic gap in birth outcomes between low-income and other women was significantly smaller when the low-income women received the income supplement than when they did not. The prenatal income supplement may be an important driver in attaining population-level equity in birth outcomes; its success could inform strategies seeking to improve maternal and child health.