Eldar Søreide

Perioperative fasting in adults and children: guidelines from the European Society of Anaesthesiology.

This guideline aims to provide an overview of the present knowledge on aspects of perioperative fasting with assessment of the quality of the evidence. A systematic search was conducted in electronic databases to identify trials published between 1950 and late 2009 concerned with preoperative fasting, early resumption of oral intake and the effects of oral carbohydrate mixtures on gastric emptying and postoperative recovery. One study on preoperative fasting which had not been included in previous reviews and a further 13 studies published since the most recent review were identified. The searches also identified 20 potentially relevant studies of oral carbohydrates and 53 on early resumption of oral intake. Publications were classified in terms of their evidence level, scientific validity and clinical relevance. The Scottish Intercollegiate Guidelines Network scoring system for assessing level of evidence and grade of recommendations was used. The key recommendations are that adults and children should be encouraged to drink clear fluids up to 2 h before elective surgery (including caesarean section) and all but one member of the guidelines group consider that tea or coffee with milk added (up to about one fifth of the total volume) are still clear fluids. Solid food should be prohibited for 6 h before elective surgery in adults and children, although patients should not have their operation cancelled or delayed just because they are chewing gum, sucking a boiled sweet or smoking immediately prior to induction of anaesthesia. These recommendations also apply to patients with obesity, gastro-oesophageal reflux and diabetes and pregnant women not in labour. There is insufficient evidence to recommend the routine use of antacids, metoclopramide or H2-receptor antagonists before elective surgery in non-obstetric patients, but an H2-receptor antagonist should be given before elective caesarean section, with an intravenous H2-receptor antagonist given prior to emergency caesarean section, supplemented with 30 ml of 0.3 mol l(-1) sodium citrate if general anaesthesia is planned. Infants should be fed before elective surgery. Breast milk is safe up to 4 h and other milks up to 6 h. Thereafter, clear fluids should be given as in adults. The guidelines also consider the safety and possible benefits of preoperative carbohydrates and offer advice on the postoperative resumption of oral intake.

Pre‐operative fasting guidelines: an update

Liberal pre‐operative fasting routines have been implemented in most countries. In general, clear fluids are allowed up to 2 h before anaesthesia, and light meals up to 6 h. The same recommendations apply for children and pregnant women not in labour. In children <6 months, most recommendations now allow breast‐ or formula milk feeding up to 4 h before anaesthesia. Recently, the concept of pre‐operative oral nutrition using a special carbohydrate‐rich beverage has also gained support and been shown not to increase gastric fluid volume or acidity. Based on the available literature, our Task Force has produced new consensus‐based Scandinavian guidelines for pre‐operative fasting. What is still not clear is to what extent the new liberal fasting routines should apply to patients with functional dyspepsia or systematic diseases such as diabetes mellitus. Other still controversial areas include the need for and effect of fasting in emergency patients, women in labour and in association with procedures done under ‘deep sedation’. We think more research on the effect of various fasting regimes in subpopulations of patients is needed before we can move one step further towards completely evidence‐based pre‐operative fasting guidelines.

Rapid implementation of therapeutic hypothermia in comatose out-of-hospital cardiac arrest survivors

Background:  The implementation of therapeutic hypothermia (TH) into daily clinical practice appears to be slow. We present our experiences with rapid implementation of a simple protocol for TH in comatose out‐of‐hospital cardiac arrest (OHCA) survivors.

Epidemiology and Contemporary Patterns of Trauma Deaths: Changing Place, Similar Pace, Older Face

AbstractBackgroundThe epidemiology of trauma deaths in Europe is less than well investigated. Thus, our goal was to study the contemporary patterns of trauma deaths within a defined population with an exceptionally high trauma autopsy rate.MethodsThis was a retrospective evaluation of 260 consecutive trauma autopsies for which we collected demographic, pre-hospital and in-hospital data. Patients were analyzed for injury severity by standard scoring systems (Abbreviated Injury Scale [AIS], Revised Trauma Score [RTS], and Injury Severity Score [ISS]), and the Trauma and Injury Severity Scale [TRISS] methodology.ResultsThe fatal trauma incidence was 10.0 per 100,000 inhabitants (17.4 per 100,000 age-adjusted ≥ 55 years). Blunt mechanism (87%), male gender (75%), and pre-hospital deaths (52%) predominated. Median ISS was 38 (range: 4–75). Younger patients (<55 years) who died in the hospital were more often hypotensive (SBP < 90 mmHg; p = 0.001), in respiratory distress (RR < 10/min, or > 29/min; p < 0.0001), and had deranged neurology on admission (Glasgow Coma Score [GCS] ≤ 8; p < 0.0001), compared to those ≥ 55 years. Causes of death were central nervous system (CNS) injuries (67%), exsanguination (25%), and multiorgan failure (8%). The temporal death distribution is model-dependent and can be visualized in unimodal, bimodal, or trimodal patterns. Age increased (r = 0.43) and ISS decreased (r = –0.52) with longer time from injury to death (p < 0.001). Mean age of the trauma patients who died increased by almost a decade during the study period (from mean 41.7 ± 24.2 years to mean 50.5 ± 25.4 years; p = 0.04). The pre-hospital:in-hospital death ratio shifted from 1.5 to 0.75 (p < 0.007).ConclusionsWhile pre-hospital and early deaths still predominate, an increasing proportion succumb after arrival in hospital. Focus on injury prevention is imperative, particularly for brain injuries. Although hemorrhage and multiorgan failure deaths have decreased, they do still occur. Redirected attention and focus on the geriatric trauma population is mandated.

Good outcome in every fourth resuscitation attempt is achievable--an Utstein template report from the Stavanger region.

AIM OF THE STUDY Out-of-hospital cardiac arrest (OHCA) is a major cause of death in the western world. We wanted to study changes in survival over time and factors linked to this in a region which have already reported high survival rates. METHODS We used a prospectively collected Utstein template database to identify all resuscitation attempts in adult patients with OHCA of presumed cardiac origin. We included 846 resuscitation attempts and compared survival to discharge with good outcome in two time periods (2001-2005 vs. 2006-2008). RESULTS We found no significant differences between the two time periods for mean age (71 and 70 years (p=0.309)), sex distribution (males 70% and 71% (p=0.708)), location of the OHCA (home 64% and 63% (p=0.732)), proportion of shockable rhythms (44% and 47% (p=0.261)) and rate of return of spontaneous circulation (38% and 43% (p=0.136)), respectively. Bystander cardiopulmonary resuscitation (CPR), however, increased significantly from 60% to 73% (p<0.0001), as did the overall rate of survival to discharge from 18% to 25% (p=0.018). In patients with a shockable first rhythm, rate of survival to discharge increased significantly from 37% to 48% (p=0.036). In witnessed arrest with shockable rhythm survival to discharge increased from 37% to 52% (p=0.0105). CONCLUSION Overall, good outcome is now achievable in every fourth resuscitation attempt and in every second resuscitation attempt when patients have a shockable rhythm. The reason for the better outcomes is most likely multi-factorial and linked to improvements in the local chain of survival.

Prehospital advanced life support provided by specially trained physicians: is there a benefit in terms of life years gained?

Background:  The benefit of prehospital advanced life support (ALS) is disputed, as is the prehospital use of specially trained, hospital‐based physicians. The purpose of the study was to assess the health benefit from an anesthesiologist‐manned prehospital emergency medical service (EMS), and to separate the benefit of the anesthesiologist from that of rapid transport.

Quality of chest compressions during 10 min of single-rescuer basic life support with different compression: ventilation ratios in a manikin model

INTRODUCTION Good quality basic life support (BLS) improves outcome during cardiac arrest. As fatigue may reduce BLS performance over time we wanted to examine the quality of chest compressions in a single-rescuer scenario during prolonged BLS with different compression:ventilation ratios (C:V ratios). MATERIAL AND METHODS Professional paramedics were asked to perform single-rescuer BLS with C:V ratios of 15:2, 30:2 and 50:2 for 10 min each in random order. A Laerdal Medical Resusci Anne Simulator with PC Skillreporting System was used for BLS quality analysis. Total number of chest compressions, compression depth and compression rate were measured and the differences between the C:V ratios were analysed with repeated measures ANOVA. For analysis of fatigue, chest compression variables for each 2-min period were analysed and compared with the first 2-min period using repeated measures ANOVA. RESULTS Altogether 50 paramedics completed the study. The mean number of chest compressions increased significantly from 604 to 770 and 862 with C:V ratios of 15:2, 30:2 and 50:2, respectively. Chest compression rate was significantly higher with C:V ratio of 15:2 compared to 30:2 and 50:2 but was above 100 per minute for all three ratios. However, the mean chest compression depth did not change significantly between the different C:V ratios. The number of chest compressions did not change significantly with time for any of the three C:V ratios. Compression depth did decline after the first 2-min period for 30:2 and 50:2 as did compression rate for all three ratios. However all were above the guideline limits for the entire test period. CONCLUSION Increasing the C:V ratio increases the number of chest compressions during 10 min of BLS. Compression depth and compression rate were within guideline recommendations for all three ratios. We found no decline in chest compression quality below guideline recommendations during 10 min of BLS with any of the three different C:V ratios.

Cognitive dysfunction and health-related quality of life after a cardiac arrest and therapeutic hypothermia

Background: Evidence‐based treatment protocols including therapeutic hypothermia have increased hospital survival to over 50% in unconscious out‐of‐hospital cardiac arrest survivors. In this study we estimated the incidence of cognitive dysfunctions in a group of cardiac arrest survivors with a high functional outcome treated with therapeutic hypothermia. Secondarily, we assessed the cardiac arrest groups level of cognitive performance in each tested cognitive domain and investigated the relationship between cognitive function and age, time since cardiac arrest and health‐related quality of life (HRQOL).

Clinical and cellular effects of hypothermia, acidosis and coagulopathy in major injury

Hypothermia, acidosis and coagulopathy have long been considered critical combinations after severe injury. The aim of this review was to give a clinical update on this triad in severely injured patients.

Scandinavian guidelines - "The massively bleeding patient"

c. gaarder, Trauma Unit, Ullevål University Hospital, Oslo, Norway p. a. naess, Trauma Unit, Ullevål University Hospital, Oslo, Norway e. Frischknecht christensen, Aarhus Trauma Centre, Aarhus University Hospital, Denmark p. hakala, Department of Anaesthesia and Intensive Care, Helsinki University Hospital, Finland l. handolin, Department of Orthopaedics and Traumatology, Helsinki University Hospital, Finland h. e. heier, Department of Immunology and Transfusion Medicine, Ullevål University Hospital, Oslo, Norway K. ivancev, Endovascular Centre, Malmö University Hospital, Malmö, Sweden p. Johansson, Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark a. leppäniemi, Department of Surgery, Meilahti Hospital, University of Helsinki, Helsinki, Finland F. lippert, Department of Anaesthesia and Intensive Care, Rigshospitalet, Copenhagen, Denmark h. m. lossius, Norwegian Air Ambulance, Drøbak, Norway h. Opdahl, Intensive Care Unit/NBC centre, Ullevål University Hospital, Oslo, Norway J. pillgram-larsen, Department of Cardiothoracic Surgery, Ullevål University Hospital, Oslo, Norway O. Røise, Orthopaedic Centre, Ullevål University Hospital, Oslo, Norway n. O. skaga, Department of Anaesthesia, Ullevål University Hospital, Oslo, Norway e. søreide, Department of Anaesthesia and Intensive Care, Stavanger University Hospital, Stavanger, Norway J. stensballe, Department of Anaesthesia, Rigshospitalet, Copenhagen, Denmark e. Tønnessen, Department of Anaesthesia and Intensive Care, Aarhus University Hospital, Aarhus, Denmark a. Töttermann, Department of Orthopaedics, Uppsala University Hospital, Uppsala, Sweden p. ́́ Ortenwall, Trauma Unit, Department of Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden a. ́́ Ostlund, Department of Anaesthesia and Intensive care, Karolinska University Hospital, Stockholm, Sweden