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Dive into the research topics where Eldon Scott Priestley is active.

Publication


Featured researches published by Eldon Scott Priestley.


Bioorganic & Medicinal Chemistry Letters | 2017

Macrocyclic factor VIIa inhibitors

Xiaojun Zhang; Peter W. Glunz; Eldon Scott Priestley; James A. Johnson; Nicholas R. Wurtz; Vladimir Ladziata

A series of macrocyclic factor XIa (FXIa) inhibitors was designed based on an analysis of the crystal structures of the acyclic phenylimidazole compounds. Further optimization using structure-based design led to inhibitors with pM affinity for FXIa, excellent selectivity against a panel of relevant serine proteases, and good potency in the activated partial thromboplastin time (aPTT) clotting assay.


Archive | 2002

Compounds useful for treating hepatitus c virus

Eldon Scott Priestley; Carl P. Decicco; Thomas W. Hudyma; Xiaofan Zheng


Archive | 2003

Compounds useful for treating hepatitis C virus

Eldon Scott Priestley; Carl P. Decicco; Thomas W. Hudyma; Xiaofan Zheng


Archive | 2001

Novel lactam inhibitors of hepatitis C virus NS3 protease

Eldon Scott Priestley; Carl Decicco


Archive | 2007

Macrocyclic factor viia inhibitors useful as anticoagulants

Eldon Scott Priestley; Daniel L. Cheney; Nicholas R. Wurtz; Peter W. Glunz


Archive | 2006

Phenylglycinamide derivatives useful as anticoagulants

Xiaojun Zhang; Eldon Scott Priestley; Alexandra A. Nirschl; Yan Zou


Archive | 2006

Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants

Xiaojun Zhang; Alexandra A. Nirschl; Yan Zou; Eldon Scott Priestley


Archive | 2013

Imidazothiadiazole and imidazopyridazine derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation

Alain Martel; François Tremblay; Anne Marinier; Eldon Scott Priestley; Shoshana Posy; R. Michael Lawrence; Michael M. Miller


Archive | 2007

BICYCLIC LACTAM FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS

Nicholas R. Wurtz; Eldon Scott Priestley; Daniel L. Cheney; Xiaojun Zhang; Brandon Parkhurst; Vladimir Ladziata


Circulation | 2017

Abstract 13794: An Orally-Active Small-Molecule Antagonist of the Platelet Protease-Activated Receptor-4, BMS-986141, Prevents Aeterial Thrombosis With Low Bleeding Liability in Cynomolgus Monkeys

Pancras C. Wong; Carol A. Watson; Jeffery Bostwick; Jacques Banville; Ruth R. Wexler; Eldon Scott Priestley; Anne Marinier; Michel Bouvier; David A. Gordon; William A. Schumacher; Jing Yang

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Yan Zou

Bristol-Myers Squibb

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