Elena Carceller

Synthesis of cis-bicyco¦13.3.0¦oct-3-ene-2,7-dione, a highly functionalized cyclopentanoid intermediate

Abstract cis -Bicyclo¦3.3.O¦oct-3-ene-2,7-dione (1) has been synthesized either from cis -bicyclo¦3.3.0¦octane-3,7-dione (2) or the ¦2+2¦-cycloadduct 10 of 5-trimethylsilylcyclopentadiene with dichloroketene. As anticipated, the conjugated double bond of acetal 9 acts as a Michael acceptor in front of nucleophiles such as PhSeCH 2 Li to give the exo -1,4-addition derivative 16, from which intermediates with functionalized endo -side chains are easily worked up.

Synthesis of triquinacene derivatives: New approach towards the synthesis of dodecahedrane

Sequential treatment of the lactol (I) with ethynylmagnesium bromide (II), tBuMeZSiCI (III) and Me3SiCl (IV) yields a diastereomeric mixture of (V).

Direct entry to the all-cis tricyclo[5.2.1.O4,10]decane (perhydrotriquinacene) skeleton by a cobalt mediated intramolecular cyclization

Abstract The perhydrotriquinacene skeleton has been synthesized by a Pauson-Khand bis-annulation process.

Improved Synthesis of Tricyclo (5.2.1.04,10) Decane-2,5,8-Trione by a Pauson-Khand Intramolecular Bis-Annulation

Abstract The title compound 1 has been synthesized from diol 3a, either directly or after protection of the two hydroxy groups as benzyl ethers, by an intramolecular Pauson-Khand bis-annulation, followed by catalytic hydrogenation and oxidation in overall yields ranging from 15% (free diol) to 35% (dibenzyl ethers).

Stereoselectivity in Intramolecular Cobalt-Mediated Bis-Annulations Leading to Triquinacene Derivatives

Abstract In order to account for the high stereoselectivity observed in the intramolecular cobalt-mediated bis-annulation of 2a,b a SN1 epimerization of the C(5) assymmetric center must be postulated.

A Short, Efficient Synthesis of 6-Cyano-1-tetralones

Abstract A new, short and high-yield synthesis of 6-cyano-1-tetralones is described. Triflate intermediates 8 and 9 are versatile intermediates for the synthesis of other 6-substituted tetralones.

Synthesis of tricyclo(5.2.1.04,10)decane-2,5,8-trione from deslongchamps's diketone

Abstract Tricyclo(5.2.1.0 4,10 )decane-2,5,8-trione (1) has been synthesized by base-induced cyclization of intermediates of type A readily available from Deslongchampss diketone 2.

Synthesis and hydroboration/oxidation of tricyclo(5.2.1.04,10)dec-8-ene-2,5-dione (bis-acetal): new synthetic entry to tricyclo(5.2.1.04,10)decane-2,5,8-trione

Abstract Tricyclo(5.2.1.04,10)decane-2,5,8-trione (4) has been synthesized from the corresponding bis-acetal of the unsaturated diketone 20 by a hydroboration/oxidation/deprotection sequence.

An Improved Synthesis of Deslongchamps's Diketone by Direct Regioselective Functionalization of endo-Dicyclopentadiene

Abstract A high yield three-step synthesis of endo-tricyclo[5.2.1.02,6]deca-4,8-dione (Deslongchampss diketone) by a stepwise regioselective oxymercuration of commercial endo-dicyclopentadiene is described.

A novel multi-functional KDM1A chemoprobe as a tool for clinical cancer research.

e24242Background: It is crucial for clinical studies to correlate the effects in patients with the degree of target inhibition. If biomarkers under the immediate control of the pharmacological targ...