Elena Ghedini
Ca' Foscari University of Venice
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Publication
Featured researches published by Elena Ghedini.
Chemistry: A European Journal | 2009
Laura Contessotto; Elena Ghedini; Francesco Pinna; Michela Signoretto; G. Cerrato; Valentina Crocellà
Pure and modified silica materials were synthesised by a sol-gel process and used as carrier for the controlled release of ibuprofen, selected as model drug. A one-step synthesis was optimised for the preparation of various silica-drug composites by using tetraethoxysilane and 3-aminopropyltriethoxysilane as precursors at different molar ratios. The presence of aminopropyl groups on the silica surface influences the drug-delivery rate leading to a high degree the desorption process controlled.
Catalysis Letters | 2015
Valentina Nichele; Michela Signoretto; Francesco Pinna; Elena Ghedini; Matteo Compagnoni; Ilenia Rossetti; Giuseppe Cruciani; Alessandro Di Michele
The activity of bimetallic Ni–Cu catalysts in ethanol steam reforming was evaluated and compared to the activity of the corresponding monometallic Ni catalyst. Copper addition positively affected the catalytic activity only if the proper metal–support interactions, as well as the proper ratio between the different reducible species, were maintained. This target can be pursued by tuning the synthesis conditions.Graphical Abstract.
Chemistry: A European Journal | 2012
Elena Ghedini; Valentina Nichele; Michela Signoretto; G. Cerrato
A series of titanium oxides was prepared by using a surfactant-template method (STM) and used as a carrier for the sustained release of ibuprofen, which was chosen as a model drug. This STM provides an efficient route to TiO(2) matrices with both high surface area (when compared with those that were obtained by using traditional synthetic approaches) and well-defined mesoporous textures. Some parameters of the synthetic procedure were varied: pH value, surfactant, and thermal treatment. The physicochemical nature of the surface carriers were investigated by means of N(2) -physisorption measurements and FTIR spectroscopy. The effect of the amount of drug on the release kinetics was also investigated. The drug delivery was evaluated in vitro in four different physiological solutions (that simulated the gastrointestinal tract) to analyze the behavior of the TiO(2) -based systems if they were to be formulated as oral DDSs. Our optimized approach is a good alternative to the classical methods that are used to prepare efficient TiO(2) -based drug-delivery systems.
Studies in Surface Science and Catalysis | 2008
Elena Ghedini; Michela Signoretto; Francesco Pinna; D. Guarascio; G. Cerrato
Mesoporous silica materials were modified with aminopropyl groups through post-synthesis grafting and the resulting samples were investigated as matrixes for controlled drug delivery. In particular we have investigated the influence of aminopropyl groups amount on the chemical-physical properties of obtained materials and on the drug adsorption-desorption processes.
Studies in Surface Science and Catalysis | 2008
Michela Signoretto; Valentina Nichele; Elena Ghedini; Francesco Pinna; G. Cerrato
Pure and modified silica materials were prepared by the sol-gel process and used as carrier for the controlled release of ibuprofen. A one-step synthesis was carried out for the preparation of the silica-drug composites and the sol-gel method was improved by using the ultrasounds in order to replace of acid or basic catalysts. It was found that the presence of methyl groups on the silica surface influences the drug delivery rate leading to a high degree of control of the desorption process.
Topics in Catalysis | 2018
Federica Menegazzo; Maela Manzoli; Alessandro Di Michele; Elena Ghedini; Michela Signoretto
Gold nanoparticles prepared by sol immobilization using PVA as protecting agent were supported over different oxides (CeO2, ZrO2 and TiO2). The activity of the gold catalysts was tested in the oxidative esterification of furfural by an efficient and sustainable process. The samples supported on ceria and zirconia (AuCe and AuZr) have shown complete conversion and selectivity under mild reaction conditions. The catalytic performances are better than those obtained with the reference commercial AuTiWGC. The DR UV–Vis spectroscopic results indicate that gold nanoparticles that give rise to similar plasmonic band, as in the case of AuCe and AuZr, are very active and highly selective. The extent of crystallinity of the gold particles seems to have no influence on the activity of the sol immobilized catalysts. The null selectivity of the catalyst supported on titania is probably due to the presence of residual sulphate groups. The effect of the oxygen pressure on the furfural conversion is almost negligible for all the samples and, despite of the oxygen pressure lowering, it is possible to obtain always high conversion and selectivity. The selectivity of the process is unaffected by using air instead of oxygen, even at very low pressures. On the contrary, the presence of PVA seems to influence the conversion when working in air at low pressures, due to a dilution effect of the oxidant atmosphere. This is confirmed by the results obtained for a sample synthesized by deposition precipitation of gold on zirconia, where the high metal dispersion and the absence of the protecting agent allowed to reach high conversion even in low air pressure.
Molecules | 2018
Federica Menegazzo; Elena Ghedini; Michela Signoretto
The present paper reviews recent advances on the direct synthesis of 5-hydroxymethylfurfural (HMF) from different kinds of raw biomasses. In particular, in the paper HMF production from: (i) edible biomasses; (ii) non-edible lignocellulosic biomasses; (iii) food wastes (FW) have been reviewed. The different processes and catalytic systems have been reviewed and their merits, demerits and requirements for commercialisation outlined.
Nanoarchitectonics for Smart Delivery and Drug Targeting | 2016
Michela Signoretto; Elena Ghedini; Valentina Nichele; Francesco Pinna; D. Casotti; Giuseppe Cruciani; Valentina Aina; G. Martra; G. Cerrato
In this work an innovative drug-delivery system (DDS) was formulated by using a hybrid matrix as carrier. In order to achieve the optimal synergy between the organic and the inorganic components, a series of TiO 2 –chitosan and SiO 2 –chitosan systems were synthesized by varying, among the several parameters, the chitosan molecular weight, chitosan amount, and the chemical modification of inorganic precursors. Ibuprofen and metoprolol tartrate were chosen as model drugs. The physicochemical nature of the surface carriers has been investigated by means of N 2 physisorption measurements, thermal analyses (TG-DTA), infrared spectroscopy (FT-IR), and transmission electron microscopy (HR-TEM); drug-delivery tests are performed in vitro in three different physiological solutions (simulating the gastrointestinal tract) in order to analyze the behavior of the hybrid-based systems as oral DDS formulations. The use of optimal synthetic conditions allowed us to obtain a hybrid drug-delivery system that is highly biocompatible, chemically resistant, and has high control of drug release.
Cardiovascular Pathology | 2014
Elena Ghedini; Cristina Pizzolitto; G. Albore; Federica Menegazzo; Michela Signoretto; L. Operti; G. Cerrato
In the present contribution a versatile and sustainable strategy for the formulation of a drug delivery system for the controlled release of antibiotics for topical administration was developed. Silver sulfadiazine (AgSD), an antimicrobial agent for preventing infections on burn wounds, was selected as model drug. The drug delivery system was formulated by an effective one-pot sol–gel approach by using chitosan and silica alkoxides as organic and inorganic precursor, respectively, in order to obtain a hybrid material. Different silica alkoxides, characterized by different functionalities of the organic chain, and a series of synthetic parameters (water/precursor ratio, excipients, and drug amount) were evaluated. The composition of the hybrid gel was selected to achieve the optimal synergy between the physico-chemical features and the gel texture taking into great account the final application, i.e., a topical administration. Drug delivery tests were performed in vitro with a Franz vertical diffusion cell. The new drug delivery system reaches the therapeutic concentration in the same time of a commercial sample and allows the complete release of even 2.5 wt% AgSD. The drug delivery is totally controlled and gradual over 48 h and the formulated is stable in time. Such innovative organic–inorganic hybrid material is therefore an efficient drug delivery system for acute skin infections treatment by controlled delivery.Graphical Abstract
Applied Catalysis B-environmental | 2010
Fabrizio Cavani; Stefania Guidetti; Luca Marinelli; Marco Piccinini; Elena Ghedini; Michela Signoretto