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Featured researches published by Eliane Aparecida Campesatto.


Revista do Colégio Brasileiro de Cirurgiões | 2012

Estudo comparativo do uso tópico de própolis verde e vermelha na reparação de feridas em ratos

Lara Lívia Valença Batista; Eliane Aparecida Campesatto; Maria Lysete Bastos de Assis; Ana Paula Fernandes Barbosa; Luciano Aparecido Meireles Grillo; Camila Braga Dornelas

OBJECTIVE To evaluate the healing action of green and red propolis, correlating it with the content of flavonoids. METHODS We performed quantification of total flavonoids of green and red propolis ethanol extracts for subsequent incorporation in ointment base to 20%. We used 20 Wistar rats divided into four groups: 0.9% saline (S), ointment base (B), green propolis ointment (G) and red propolis ointment (R). All animals were submitted to excisional lesions in the midian back region. The rats were treated daily for 15 days. During this period we observed weight, body temperature and diameters of the wounds. For histological analysis, samples were collected from wounds. At the end of the experiment we performed blood collection and removal of the kidney and liver for biochemical and histological analyzes. RESULTS The levels of total flavonoids of green (4.50%) and red (5.92%) propolis were high (> 2%), but, while the latter showed a content larger than the former, the evolution of green propolis was better in the repair of wounds, both macroscopically and histologically. There were no nephrotoxicity or hepatotoxicity, a result confirmed by biochemical tests (ALT and albumin). Propolis influenced the reduction of total cholesterol, triglycerides and glucose. CONCLUSION There was no correlation between total flavonoid contents and the healing action of propolis. This reveals the need for elucidation of the flavonoids found in each class of propolis to unravel which one(s) would be important for the healing process.


Natural Product Research | 2014

Antinociceptive and anti-inflammatory effects of flavonoids PMT1 and PMT2 isolated from Piper montealegreanum Yuncker (Piperaceae) in mice

Aline Cavalcanti de Queiroz; Harley da Silva Alves; Luiz Henrique Agra Cavalcante-Silva; Thays de Lima Matos Freire Dias; Mariana da Silva Santos; Gabriela Muniz de Albuquerque Melo; Eliane Aparecida Campesatto; Maria Célia de Oliveira Chaves; Magna Suzana Alexandre-Moreira

In this study, we identified the antinociceptive and anti-inflammatory effects of two flavonoids (PMT1 and PMT2) from Piper montealegreanum. The antinociceptive effect was evaluated using the classical tests: acetic acid-induced writhing, formalin and hot plate test. PMT1 and PMT2 (0.1, 1, 30 and 100 μmol/kg, i.p.) reduced the writhings, with an ID50 of 0.58 and 0.44 μmol/kg, respectively. Moreover, these flavonoids (100 μmol/kg, i.p.) inhibited paw-licking time in the neurogenic phase of the formalin test, but only PMT2 was active in the inflammatory phase. However, PMT1 and PMT2 (100 μmol/kg, i.p.) did not increase the latency time of the animals in the hot plate. In order to evaluate the anti-inflammatory effect of these flavonoids, capsaicin-induced ear oedema was carried out. Both flavonoids (100 μmol/kg, i.p.) were active in this model. These results suggest that PMT1 and PMT2 have antinociceptive and anti-inflammatory activities.


Toxicology in Vitro | 2017

Cytotoxic mechanism of Baccharis milleflora (Less.) DC. essential oil

Camila Bugnotto Pereira; Carla Cristine Kanunfre; Paulo Vitor Farago; Débora Maria Borsato; Jane Manfron Budel; Beatriz Helena L. N. Sales Maia; Eliane Aparecida Campesatto; Adilson Sartoratto; Marilis Dallarmi Miguel; Obdulio Gomes Miguel

The aim of this study was to investigate the cytotoxic activity of the essential oil from cladodes of Bacharis milleflora in relation to Jurkat, Raji and HL-60 cells, as well as exploring the cell mechanisms in order to elucidate how the cytotoxic process occurs. The presence of the following volatile compounds was detected by GC-MS: bicyclogermacrene (12.16%), germacrene D (11.18%), (E)-caryophyllene (9.28%), and α-humulene (8.05%). In general, IC50 values lower than 50μg/mL were obtained for all the tumor cells at 24, 48 and 72h by MTT assay. The decrease in cell DNA content was demonstrated due to the inhibition of the proliferation of Jurkat, Raji and HL-60 cells by B. milleflora essential oil. In particular, Raji cells presented the greatest inhibition of cell proliferation and they were subsequently used to investigate cell death mechanisms. B. milleflora essential oil promoted G0/G1 arrest and also induced cell fragmentation, which was represented by an increase in the sub-G0 population, indicating cell death induced by apoptosis. The selectivity index was 3.97. Necrotic cell death, coupled with low levels of apoptotic cell death, was observed by conventional EB/AO and Hoechst 33342 staining assays, demonstrating that this essential oil acts via both necrotic and apoptotic mechanisms.


Revista Brasileira de Plantas Medicinais | 2016

Anxiolytic-like effect of Citrus limon (L.) Burm f. essential oil inhalation on mice

Max Denisson Maurício Viana; R.M. Cardoso; N.K.G.T. Silva; Maria Alice Pimentel Falcão; Ana Carolina Santana Vieira; Alexandre-Moreira; Eliane Aparecida Campesatto

Experimental in vivo study aimed to characterize the anxiolytic-like effect of the Citrus limon fruit peel’s essential oil (CLEO) in animal models of anxiety, besides evaluating the viability J774.A1 cells in vitro through the MTT reduction method at the concentrations of 10 and 100 µg/mL. The anxiolytic behavior was evaluated in Swiss mice (n = 8) using the methodology of Elevated Plus-Maze (EPM) and Open-Field (OF). CLEO was tested by inhalation at the doses of 100, 200, and 400 µL, and as control, animals were subjected to inhalation of the vehicle (saline solution 0.9% + Tween80®) and intraperitoneal administration of diazepam (1.5 mg/kg). In the cell viability assay, it was observed that none of the concentrations showed cytotoxicity. OF test showed significant anxiolytic activity at all tested doses of OECL, compared to the control group, without changing the motor performance of the animals. Corroborating OF data, the EPM test confirmed anxiolytic activity in at least two doses of the tested oil (200 and 400 µL), justified by the number of entries and increase in the percentage of time in the open arms. The data analysis of this study evidenced that inhalation of OECL was able to induce an anxiolytic behavior in mice; however, further studies are required to ensure its safe use by the population.


Revista Brasileira de Plantas Medicinais | 2015

Estudo do potencial antimicrobiano e citotóxico da espécie Pouteria venosa (Sapotaceae)

Raíssa Fernanda Evangelista Pires dos Santos; I.S.M. Silva; Regina Célia Santos Sales Verissimo; Ingrid Martins Leite Lúcio; Eliane Aparecida Campesatto; Lucia M. Conserva; Maria Lysete de Assis Bastos

This experimental in vitro study aimed to investigate the antimicrobial and cytotoxic potential of four fractions and one ethanolic extract of the specie Pouteria venosa used as a medicinal plant. The antimicrobial activity was determined by microbial sensitivity tests, as the method of disk diffusion and the broth microdilution method for determination of Minimum Inhibitory Concentration (MIC). The evaluation of the cytotoxicity was obtained by the Metiltetrazolium colorimetric method. In the antimicrobial activity research, the main results were obtained against the Staphylococcus aureus for the AcOEt fraction of the stem bark MIC 125 μg/mL, Streptococcus pneumoniae and Proteus mirabilis for the AcOEt fraction from the stem bark, CIM 250 μg/mL, Staphylococcus epidermidis, Pseudomonas aeruginosa to the AcOEt fraction of the leaves and stem bark, MIC 250 μg/mL. All samples did not react for the fungi tested. The AcOEt fraction of the stem bark was considered non-toxic and can be used at in vivo pre-clinical testing.


BMC Proceedings | 2014

Study of antimicrobial potential and cytotoxic of Cordia nodosa species

Raíssa Fernanda Evangelista Pires dos Santos; Isabelle Souza de Mélo Silva; Lukas Reis d'Costa; Andriele Mendonça Barbosa; Klebson Santos Silva; Mariene Ribeiro Amorim; Fernando Mendonça Diz; Thaís Honório Lins; Regina Célia Santos Sales Verissimo; Francine Ferreira Padilha; Eliane Aparecida Campesatto; Maria Lysete de Assis Bastos

Study of antimicrobial potential and cytotoxic of Cordia nodosa species Raíssa Fernanda Evangelista Pires dos Santos, Isabelle Souza de Mélo Silva Silva, Lukas Reis d’Costa, Andriele Mendonça Barbosa, Klebson Santos Silva, Mariene Ribeiro Amorim, Fernando Mendonça Diz, Thais Honório Lins, Regina Célia Santos Sales Verissimo, Francine Ferreira Padilha, Eliane Aparecida Campesatto, Maria Lysete de Assis Bastos


BMC Proceedings | 2014

Evaluation of antimicrobial potential and cytotoxic of Pouteria venosa species

Raíssa Fernanda Evangelista Pires dos Santos; Isabelle Souza de Mélo Silva; Eleci Adriano Hendges; Andressa Letícia Lopes da Silva; Andriele Mendonça Barbosa; Klebson Silva Santos; Renata Rego de Souza; Thaís Honório Lins; Regina Célia Santos Sales Verissimo; Francine Ferreira Padilha; Eliane Aparecida Campesatto; Maria Lysete de Assis Bastos

Evaluation of antimicrobial potential and cytotoxic of Pouteria venosa species Raissa Fernanda Evangelista Pires dos Santos, Isabelle Souza de Melo Silva Silva , Eleci Adriano Hendges, Andressa Leticia Lopes da Silva, Andriele Mendonca Barbosa, Klebson Silva Santos, Renata Rego de Souza, Thais Honorio Lins, Regina Celia Santos Sales Verissimo, Francine Ferreira Padilha, Eliane Aparecida Campesatto, Maria Lysete de Assis Bastos


BMC Proceedings | 2014

Evaluation of antibacterial and toxicity activity in vitro of extracts from Tournefortia bicolor S.W (Boraginaceae)

Isabelle Souza de Mélo Silva; Andressa Letícia Lopes da Silva; Raíssa Fernanda Evangelista Pires dos Santos; Renata Rego de Souza; Andriele Mendonça Barbosa; Klebson Silva Santos; Mariene Ribeiro Amorim; Lenilson Santos da Trindade; Laiza Canielas Krause; Eliane Aparecida Campesatto; Francine Ferreira Padilha; Maria Lysete de Assis Bastos

Evaluation of antibacterial and toxicity activity in vitro of extracts from Tournefortia bicolor S.W (Boraginaceae) Isabelle Souza de Melo Silva, Andressa Leticia Lopes da Silva, Raissa Fernanda Evangelista Pires dos Santos, Renata Rego de Souza, Andriele Mendonca Barbosa, Klebson Silva Santos, Mariene Ribeiro Amorim, Lenilson Santos da Trindade, Laiza Canielas Krause, Eliane Aparecida Campesatto, Francine Ferreira Padilha, Maria Lysete de Assis Bastos


Applied Biochemistry and Biotechnology | 2013

Anti-inflammatory and Antinociceptive Activity of Chitin-binding Lectin from Canna Limbata Seeds

Theolyta S. Araújo; Claudener Souza Teixeira; Maria Alice Pimentel Falcão; Vanir R. Pinto Junior; Mayara Q. Santiago; Raquel G. Benevides; Plínio Delatorre; Jorge Luiz Martins; Magna Suzana Alexandre-Moreira; Benildo Sousa Cavada; Eliane Aparecida Campesatto; Bruno Anderson Matias Rocha


Revista Brasileira de Plantas Medicinais | 2015

Avaliação do potencial biológico da Tabebuia aurea(Silva Manso) como fonte de moléculas bioativas para atividade antimicrobiana, antiedematogênica e antirradicalar

Raíssa Fernanda Evangelista Pires dos Santos; Lucia M. Conserva; Maria Lysete de Assis Bastos; Eliane Aparecida Campesatto

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Lucia M. Conserva

Federal University of Alagoas

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