Eliane Lopes Rosado

Polymorphism in the PPARgamma2 and beta2-adrenergic genes and diet lipid effects on body composition, energy expenditure and eating behavior of obese women

In order to evaluate the effect of polymorphism in the PPARgamma2 and beta2-adrenergic genes and diet lipids on body composition, energy expenditure and eating behavior of obese women, 60 subjects were submitted to anthropometric, biochemical, dietary, molecular, basal and postprandial metabolism (indirect calorimetry) and eating behavior (visual analog scale) evaluation. Fat and saturated fatty acid (SFA) high diet was used to assess postprandial metabolism. The frequency of Pro12Pro/Gln27Gln, Pro12Pro/Gln27Glu, Pro12Pro/Glu27Glu and Pro12Ala/Gln27Glu genotypes was 35.71%, 30.37%, 23.21% and 10.71%, respectively. These values were not significant (p>0.05) for the dietary, anthropometric, biochemical and metabolic parameters. The Pro12Ala/Gln27Glu group was found to present greater energy used in postprandial period (EUPP). The presence of the PPARgamma2 gene variant, independent of beta2-adrenergic gene polymorphism, resulted in fat oxidation increase. Also, this group presented higher satiety, compared to the Pro12Pro/Gln27Gln group. The presence of the variant alleles in the PPARgamma2 gene suggests benefits in food intake control.

ω-3 polyunsaturated fatty acid supplementation does not influence body composition, insulin resistance, and lipemia in women with type 2 diabetes and obesity.

To evaluate the influence of ω-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on body composition, insulin resistance, and lipemia of women with type 2 diabetes, the authors evaluated 41 women (60.64 ± 7.82 years) with high blood pressure and diabetes mellitus in a randomized and single-blind longitudinal intervention study. The women were divided into 3 groups: GA (2.5 g/d fish oil), GB (1.5 g/d fish oil), and GC (control). The capsules with the supplement contained 21.9% of eicosapentaenoic acid and 14.1% of docosapentaenoic acid. Biochemical (glucose, glycated hemoglobin, total and fractional cholesterol, triglycerides, and insulin) and anthropometric (body mass, stature, waist circumference [WC], and body composition) evaluations were performed before and after the 30 days of intervention. Homeostasis model assessment-insulin resistance and the Quantitative Insulin Sensitivity Check Index were used to evaluate the insulin resistance and insulin sensitivity (IS), respectively. GB presented a greater loss of body mass and WC (P < .05), greater frequency of glycemic and total cholesterol reduction, and an increase of high-density lipoprotein cholesterol compared with GA. Thus, a high dose of ω-3 PUFA can reduce IS. A lower dose of ω-3 PUFA positively influenced body composition and lipid metabolism.

Influence of the dietary intake of medium chain triglycerides on body composition, energy expenditure and satiety; a systematic review

Increased prevalence of obesity is associated with the growth of chronic degenerative diseases. One of the main factors associated with this increase is the change in nutritional status of individuals. Medium chain triglycerides (MCT) are rapidly metabolized and less stored in the adipose tissue, being a possible tool for weight control. In order to analyze the influence of consumption of this lipid on satiety, body composition and energy expenditure (EE), a literature review was performed of controlled clinical studies reported in PUBMED and ELSEVIER between the years 2000 and 2010. Fourteen articles were selected presenting short and long-term intervention. Among these, six showed a decrease in body mass of individuals, with consequent loss of weight. Only one showed a positive effect on satiation and four showed an increase in EE. Thus the results are inconclusive and there is a need for further controlled studies with standardized amounts of MCT, so that its use can become an alternative for obesity nutritional treatment.

Efecto de la dieta y de los genes PPARγ2 y b2-adrenérgico en el metabolismo energético y en la composición corporal de mujeres obesas

Objective: To investigate the prevalence of trematode Aspidogastrea in the freshwater mussels in the Yangtze River basin within Anhui province, China. Methods: We initially harvested the freshwater mussels living in the Yangtze River running through Anhui area, and labeled them with corresponding number. Then the samples were dissected for isolating the flukes, which were identified by conventional staining. Results: Infection rate of trematode Aspidogastrea in freshwater mussels in the Yangtze River basin within the territory of Anhui province was 30.38℅(103/339)in general, and a total of 912 flukes of Aspidogastrea were detected in the 103 mussels, with average infection rate of 8.85 for each mussel. Conclusion: Trematode Aspdogastrea is prevalent in the freshwater bivalves living in the Yangtze River basin running through Anhui area, and the treamatode was identified as Aspidogaster sp. belong to Aspidogaste under Aspidogastridae of Aspidogastrea.Objective: to assess the use of oral nutritional supplements analyzing the reason for prescription and its implication in caloric-protein intake. Setting: study performed at a university hospital of 350 beds with medical and surgical specialties. Subjects, patients: Patients inclusion was done by selecting all starting oral nutritional supplement prescription. Exclusion criteria were being younger than 18 years, being admitted to the Intensive Care Unit, having cognition or communication impairments, being on concomitant parenteral nutrition or requiring complete enteral diet, and/or using nasogastric tube for feeding. We also excluded special enteral diets, specifically designed for certain conditions. Interventions: One-year long prospective study on prescription of oral nutritional supplements. Through clinical chart review and personal interview, we recorded demographic data, nutritional parameters, characteristics of the diet and supplement, and caloricprotein intake prescribed and ingested. The data were introduced in an Access97 database and processed by means of SPSS software for Windows®. We performed a descriptive study of quantitative and qualitative variables, a χ2 analysis between qualitative variables, and a comparative analysis between means of all paired data by means of the student’s t test, and variance analysis between quantitative variables. The significance level was set at p < 0.05. Results: we were only able to analyze 77 out of 130 prescriptions for nutritional supplements since we could not adequately interview the remaining patients, mainly due to neurological impairments. Mean age was 74.8 years (SD = 12) and 50.6% were women. The departments prescribing the highest number of supplements were hematology (22.1%) and internal medicine (20.8%). GI neoplasm was the most frequent diagnosis at admission (27.3%). The most frequent indication was kwashiorkor (45.5%), with 15.6% of patients being well nourished. Mean therapy duration was 11 days (SD = 11.1), and the main reason for termination was hospital discharge (70.1%). The supplement was concomitantly prescribed with the meals in 70.6% of the cases, and more than halfMaterial y metodos: Estudio retrospectivo de 55 pacientes de 65,4 ± 14,7 anos, 35,7% mujeres y 64,3% varones con un IMC 27,87 ± 5,56 kg/m (0% con IMC 30 kg/m ) en tratamiento con NPT con una duracion de 28 ± 5 dias (mas de 20 dias en el 75% de los casos). El 16,1% presentaba Diabetes Mellitus previa al inicio de NPT. En el 64,3% de los pacientes, la fistula ocurria tras cirugia reciente: en un 38.8% tras reseccion de colon, 16,6% de intestino delgado y 13,9% de estomago. La NPT se planificaba para aportar diariamente 1,5 × Gasto Energetico Basal, 1,5 g/kg/dia de proteinas, 6 mg de vitamina B 12 y 414 μg de acido folico. Ninguna solucion contenia hierro.Objective. To assess the impact of weight loss in clinical progression of the comorbidities in a group of morbid obese patients submitted to surgical treatment with the duodenal switch technique. Study setting. Between 2001-2006, we have operated by the duodenal crossing technique a total of 118 morbid obese patients (97 women and 21 men), mean age 42.6 years. Average pre-surgical BMI was 49.7, with average overweight of 69.1 kg. After surgical intervention, we have prospectively assessed the progression of the main comorbidities (arterial hypertension, diabetes, OSAS, osteoarticular pathology, dyslipidemia), according to the subscale of the BAROS scoring system. Postsurgical controls are done at months 3, 6, 12, 18, and 24 and annually thereafter. We have followed-up 110 patients, of whom 90 presented comorbidities, being the ones studied. Results. At 3 months post-surgery, we observed a decrease in the mean value of %WL to 31%, and a mean BMI value of 41.3, the percentage of lost BMI being 40.3%. Most of the weight loss occurred within 2 years, with %WL of 74.8% and a percentage of lost BMI of 97.7%. In 68 patients (75.5%) there was resolution of their comorbidities, 14.4% having improvement, and 10% with no improvement in spite of the surgery. Of patients achieving complete resolution, almost all of them achieved it within two years after surgery. Cure rates correlate with weight loss, so that at 3 months, with a mean weight loss of 25 kg (BMI decrease of 8.4 points) the comorbidity resolution rate is 45.5%. At 12 months, with a mean decrease in BMI of 16.4 points, %WL of 61.6% and % of lost BMI of 70.4%, the comorbidity resolution rate is 89.7%. At two years, by the time most of the main comorbidities resolved (68 patients), the BMI decreased by 22.4 points, the %WL 74.8% and the % of lost BMI 97.9%. Conclusion. The aim of bariatric surgery is weight loss and overweight-associated comorbidities improvement. In our study, most of the comorbidities improvement started at the third month, with the highest improvement rate occurring within two years, verifying that there is a direct relationship between post-surgical weight loss comorbidities improvement and resolution in most of the cases.Objective: To investigate the breeding rate and breeding density of Carpoglyphus lactis in stored Fructus Jujubae in Anhui, China in order to provide a scientific basis for prevention of Carpoglyphus lactis(C. lactis) from spoiling the dried fruit of such category. Methods： By the breeding nature of C. lactis, we collected samples of Fructus Jujubae, which were kept over 6 months in general, from the dried fruit shop and (or) Chinese herbal medicine warehouse, and isolated C. lactis from those samples. The mite specimens were prepared, and microscopically and morphologically identified. Species classification was done in accordance with Hughes (1976). Result:C. lactis was identified in 19 of the 300 samples, with breeding density and breeding rate of 6.52 heads/g and 6.33%. Constitute ratio at distinct developmental phase was associated with adult (including nymph, 85.71%), larva(12.27%), hypopus (0.56%) and egg(1.45%), respectively. The richness index, diversity index and evenness index was1.644, 1.644 and 0.923, respectively. Conclusion： Carpoglyphus lactis appears infesting in large quantity in the Fructus Jujubae stored in the above places in Anhui province, and the density is higher. Therefore, it is urgent to take effective measures to prevent C. lactis from spreading over other dried products stored in the same room and potential human intestinal acariasis as a result of the biological contamination.Objective: To determine possible associations between the risk of breast cancer in Brazilian women and demographic, social and economical variables, and past dietary intake. Methods: A case-control study was conducted in Joinville, Santa Catarina, Brazil, between june and november 2003 involving a group of 33 women recently diagnosed with breast cancer and a control group of 33 healthy women volunteers. Personal details, health history and past dietary intake were obtained via questionnaires and interviews. Data between groups were compared using χ2, Fisher, and Student’s t test, whilst associations were evaluated using a non-conditional logistic regression method and odds ratio (OR). Results: Statistically significant differences between the two groups were revealed with respect to age distribution (P = 0.007), family income level (P = 0.02), educational level (P 45 years), low family income (<

Interactions of the PPARγ2 polymorphism with fat intake affecting energy metabolism and nutritional outcomes in obese women.

520/month), poor educational level (primary school level or lower) and past regular consumption of pork fat and fatty meat may be factors associated with an increased risk of breast cancer.A case of peritoneal mucinous carcinomatosis in a patient who suffered a Hirschsprung disease 30 year before is presented. TH present condition caused an irreversible intestinal obstruction and the patients received home parenteral nutrition without unremarkable complications longer than two years.Introduction: Clinical nutrition is an activity realized in most of Health Centres of France, Canada, Great Britain and USA. The aim of our work was to determine activity and resources of Nutrition Units of Hospitals in the Community of Castilla y Leon. Material and methods: A questionnaire was send to all Hospitals of Castilla y Leon (SACYL); Hospital UniMaterial y método: Se estudió una población de pacientes postquirúrgicos (n = 22; 12 hombres y 10 mujeres) de 72,9 años de promedio (DE = 13,5) que fueron apareados en razón de edad y además un 40% de ellos por sexo, en dos grupos: A) con gastrectomía total (73%) o parcial (23%) por neoplasia y B) control, presencia de íleo paralítico postquirúrgico de causa no neoplásica. La duración media de la NPT fue de 14 días (DE = 2) y 13 días (DE = 2) respectivamente siendo la composición estándar de 12 g/N2, 100 kcal no proteicas/g N2, carbohidratos/lípidos: 63/38; volumen: 1.550-2.250 mL. Se realizaron controles basales habituales antes de la cirugía y al final de la NPT. Se analizaron los niveles de: Hb, Hto, contaje de linfocitos, contaje de neutrófilos y bioquímicos: glucosa, urea, creatinina, proteínas y albúmina. Análisis estadístico: test no paramétrico U de Mann Whitney y correlación de Pearson.El Órgano Oficial de SENPE, Nutrición Hospitalaria, no ha parado de crecer y prosperar a lo largo de sus 26 años de existencia. La revista se ha ido haciendo un hueco merecido en las bases de datos electrónicas y repositorios, alcanzando a los lectores interesados en su temática, no solo en España e Iberoamérica, sino también en países de ámbito sajón y en otros muy lejanos. El éxito ha traído parejo un incremento de originales, que en 2006 permitió alcanzar la cifra de 1.000 páginas publicadas. La creciente exigencia de los revisores, rechazando un treinta por ciento de los artículos recibidos, no ha sido impedimento para esta progresión, de lo que nos congratulamos. Otro de los éxitos positivos de este éxito editorial ha sido el aumento de números suplementarios de NUTR HOSP, documentos monográficos relativos a congresos, cursos, eventos o conclusiones de grupos de trabajo. La proliferación de los suplementos, muy halagüeña al comienzo, empezó a preocuparnos por las posibles desviaciones de la esencia de la revista. Vaya por delante que todos los suplementos han cumplido siempre las pautas éticas exigibles por la revista y por la SENPE, pero lo que escapaba al ámbito del comité editorial era la garantía de originalidad de todas las contribuciones, la homogeneidad en su estructura de acuerdo con las normas de publicación de la revista y, lo que es más importante, la falta de revisión por pares de sus contenidos. Esto último contradice formalmente la esencia de una revista científica. Por ello, Nutrición Hospitalaria y su comité editorial se encontraron ante un dilema: si se renuncia a la edición de suplementos que apoyan acciones especiales de la SENPE, se deja de prestar un servicio muy importante a la sociedad. Si se continua, incumplimos la normativa de revisión por pares. Hemos consultado los entornos científicos internacionales y rápidamente encontramos la solución, que colegas como Clin Nutr vienen aplicando desde hace uno o dos años: los suplementos deben aparecer bajo la cobertura de un ISSN diferente, llevando su propia paginación correlativa, en volúmenes independientes. Esta solución, que nos ha parecido la idónea, ha sido refrendada por el Comité Científico y la Junta Directiva de la Sociedad, y empezará a implementarse a partir de mayo de 2008. Así, el lector recibirá, a lo largo de los próximos meses, suplementos de Nutr Hosp ligeramente distintos. Los contenidos científicos de esta nueva línea editorial vendrán avalados por el Comité Científico Educacional y la Junta Directiva de SENPE. Creemos que con esta nueva fórmula que, como decimos, está ampliamente implantada en otras revistas científicas, se propiciará la multiplicación de los suplementos científicos de diversa índole que, en definitiva, redundará en beneficio de los miembros de SENPE y de nuestros lectores en general, sin menoscabo de las características referentes a originalidad y control que se exigen a los artículos que se publiquen en Nutrición Hospitalaria.OBJECTIVES: To analyze the complications related to enteral nutritional support in patients with lateral amyotrophic sclerosis included in our home-based mechanical ventilation program (HMVP), with a special emphasis on gastrointestinal complications. METHOD: Retrospective, descriptive study of the patients included in our HMVP directed by intensive care physicians, by means of systematic review of the medical records (included in a Microsoft Access database) during the period 2004-2011. RESULTS: In the period 2004-2011, 73 patients with a diagnosis of lateral amyotrophic sclerosis were followed: 34 (46.6%) refused nutritional support through gastrostomy or nasogastric tube, whereas 39 (53.4%) accepted. Twenty (51.3%) of the 39 patients with (home-based nutritional support) were females. The mean age of the patients was 60.6 + 13.4 years (95% CI 56.4-64.8). Diagnoses at the time of inclusion in the HMVP were: LAS, 21 cases (53.8%), and LAS with bulbar impairment 18 (43.1%). 34 patients (87.2%) were fed through percutaneous endoscopic gastrostomy (PEG), 3 (7.7%) through surgical gastrostomy, and 3 (7.7%). PEG was performed at the time of inclusion of the patients in the program, with a mean duration of 222.7 + 356.6 days (95% CI: 110.8-334.7). In patients with LAS, the mean duration was 271.4 + 449.5 days (95% CI: 130.3-412.1), and with LAS and bulbar impairment of 126.4 + 131.3 days (95% CI: 90-172.6). The mean duration of the nasogastric tube was 7.3 + 4.8 months (95% CI: 4-10.6). The mean duration of enteral nutrition was 578.6 + 872.9 days (95% CI: 304.7-852.6). There were complications in 35 patients (89.7%), and no complications occurred in only 4 patients (10.3%) (See table 2). Constipation occurred after initiating EN in 30 patients (76.9%); however, it was already present in 18 of them (60%). The remaining gastrointestinal complications observed were: abdominal bloating (9 patients; 23.1%); abdominal pain (6; 15,.4%); nausea and vomiting (5; 12.8%); diarrhea (3; 7.7%). CONCLUSIONS: Gastrointestinal complications are the most common ones; constipation stands out as the main problem in patients with LAS and HEN. However it may not be considered as a complication exclusively due to nutritional support since it is also a manifestation in the disease course. The occurrence of granulomas is also common.Obesity combined with breast cancer is a public health problem, given the high incidence and prevalence of both diseases. The aim of this review is to determine the current status of research on the relationship between the body weight of breast cancer patients and their prognosis. Overweight and obesity at the time of diagnosis are associated with a worse prognosis in breast cancer survivors. Observational studies show that breast cancer mortality is 33% higher in obese than in non-obese survivors. Furthermore, weight gain after diagnosis is common in these patients and is even greater in those receiving chemotherapy. Weight gains of 2-8 kg are observed in 68% of patients 3 years after diagnosis. Each 5 kg increase in body weight is associated with a 13% increase in breast cancer specific mortality. The mechanisms that cause this weight gain are not totally known. A higher weight gain is also associated with higher the risk of co-morbid cardiometabolic diseases, which worsen the quality of life and shorten overall survival. On the other hand, excess adipose tissue is an indirect promoter of tumor cell proliferation and releases circulating estrogens. Hence, preventing excess weight is important in these patients. An important limitation is the small number of randomised controlled trials investigating the type of diet that could be recommended specifically to breast cancer survivors. The evidence from current studies suggests that a healthy diet, low in fat and simple sugars and with a high proportion of fruit, vegetables and wholegrain products, has the potential to reduce morbidity and the risk of recurrence significantly, thus improving prognosis and quality of life in the long term.Objective To investigate the species and breeding density of acaroid mites in the stored rhizomatic traditional Chinese medicinal materials in Anhui province, China, in order to supply evidences for control and prevention of such species. Methods The stored traditional Chinese medicinal materials of root-stock origins were collected in 30 herb stores and warehouses in 17 cities across Anhui province. Mites were collected by using Tullgren funnel and directicopy, and identified under microscopy. Results 22 species of acaroid mites, belonging to 15 genera under 5 families, were identified from the total 47 stored samples, in which Tyrophagus putrescentiae，Acarus farinae, Carpoglyphus lactis, and Cologlyplus berlesei were predominant. Conclusion Breeding density of acaroid mites was high in the stored rhizomatic traditional Chinese medicinal materials in Anhui province. This indicates that the traditional Chinese medicinal herbs of root-stock origins in storage are seriously contaminated by the acaroid mites, and such infestation should be positively controlled to reduce the potential harm to public health.INTRODUCTION For critically patients, enteral immunonutrition results in notable reductions in infections and in length of stay in hospital, but not on mortality, raising the question as to whether this relate to the heterogeneous nature of critically ill patients or to the absence of the altered absorption of specific nutrients within the immunonutrient mix (e.g. iron). Immune-associated functional iron deficiency (FID) is not only one of the many causes or anaemia in the critically ill, but also a cause of inappropriate immune response, leading to a longer duration of episodes of systemic inflammatory response syndrome and poor outcome. OBJECTIVE This prospective cross-sectional study was undertaken to assess the prevalence of FID in critically ill patients during their stay in intensive care (ICU) in order to find the more appropriate population of patients that can benefit from iron therapy. METHOD Full blood cell counts, including reticulocytes (RETIC), serum iron (SI), transferring levels (TRF) and saturation (satTRF), serum TFR receptor (sTfR), ferritin (FRT) and C-reactive protein (CRP) were measured in venous blood samples from 131 random patients admitted to the ICU for at least 24 h (Length of ICU stay, LIS; min: 1 day; max: 38 days). RESULTS Anaemia (Hb < 12 g/dL) was present in 76% of the patients (Hb < 10 g/dL in 33%), hypoferremia (SI < 45 microg/dl) in 69%; satTRF < 20% in 53%; FRT < 100 ng/mL in 23%; sTfR > 2.3 mg/dL in 13%; and CRP > 0.5 mg/dL in 88%. Statistically significant correlations (r of Pearson; *p < 0.05, **p < 0.01) were obtained for serum CRP levels and WBC**, Hb*, TRF**, satTRF*, and FRT**. There was also a strong correlation between TRF and FRT (-0.650**), but not between FRT and satTRF or SI. LIS correlated with Hb*, CRP**, TRF*, satTRF* and FRT**. CONCLUSIONS A large proportion of critically ill patients admitted to the ICU presented the typical functional iron deficiency (FID) of acute inflammation-related anaemia (AIRA). This FID correlates with the inflammatory status and the length of stay at the ICU. However, 21% of the ICU patients with AIRA had an associated real iron deficiency (satTRF < 20; FRT < 100 and sTfR > 2.3). Since oral supplementation of iron seems to be ineffective, all these patients might benefit of iv iron therapy for correction of real or functional iron deficiency, which in turn might help to ameliorate their inflammatory status.In August 1976, a young man named LeRoy fell from a ledge, fracturing his femur. Major internal bleeding was suspected. During a laparotomy, the trauma team ensured that all internal organs were intact and the orthopedic team set his fracture. Thirty days later, LeRoy died. He had eaten little; each day he only received three liters of glucose, the equivalent of 510 calories, intravenously. The glucose was insufficient to meet his nutritional needs, and he lost over 20% of his body weight during his hospital stay. The cause of death was due to “physicianinduced” malnutrition. Meanwhile, a paper around the same time documented that the prevalence of malnutrition in Boston hospitals was 44% and that malnutrition itself was a predictor of higher complication and death rates. As a result, like-minded physicians formed a society that created training programs and encouraged formation of hospital nutrition teams. Industry produced nutrition formulas and catheters. Complications in sick hospitalized patients plummeted while survival rates rose, and California passed legislation to mandate nutritional support. Though the health care industry recognized the importance of nutrition in patient care, Congress failed to pass fiscal support for nutrition teams. As a result, hospitals disbanded their newly created nutrition teams, nutrition education and skills declined, and hospital complications and death rates have risen again.Some bioethicists consider older age as a limiting factor for receiving special medical care. Older adults comprise the majority of home enteral nutrition patients (neoplams of the head, neck, and upper gastrointestinal tract neuromuscular swallowing disorders, dementia, etc) On the contrary, there are very few data on Home Parenteral Nutrition (HPN) in the elderly. We report these of a 75 years old man affected from a severe short bowel syndrome due to mesenteric thrombosis. After a hospital stay of two months he was sent home on HPN. His current caregiver was her wife, a 72 year old woman suffering from incipient Parkinson’s disease. HPN lasted for 11 years and was stopped because of clinical deterioration. During this time he presented 5 catheter- related infections (1.3 episodes/1,000 days). 5 catheters were used (average length 788 days). He was hospitalized four times because of HPN complications. Functional status was maintained along almost all the length of HPN. Conclusions: The rate of complications in this patient was similar to other groups of age receiving HPN. The technique was not burdensome for the family. Older age cannot be consider, by itself a limiting factor when receiving long term nutritional support.Patients submitted to hematopoietic stem cells transplantation (HSCT) have an increased risk for having hyponutrition, both in the phase prior to transplantation and after this one. The indication of specialized nutritional support is common in allogenic HSCT, whereas patients submitted to auto-HSCT need it in the presence of complications that compromise an adequate nutrients intake. Enteral nutrition through a nasogastric tube has difficulties in these patients; the presence of mucositis delays the indication for enteral nutrition, which usually is poorly tolerated. Thus, frequently parenteral nutrition needs to be used as the route for nutritional support. The use of specific substrates, such as glutamine, is a controversial issue.La edad media fue 4,29 anos (0,1-14,4); el 48% de los ninos tenian menos de 3,5 anos. En el 70% de los casos, el motivo de la indicacion fue la disminucion de la ingesta. La duracion media fue 116,16 dias (4-1.165), manteniendose durante menos de 100 dias en el 79% de los pacientes. El porcentaje calorico medio administrado fue del 68%, precisando el 48% de la serie un aporte < 50%. El tipo de acceso inicial fue la sonda nasogastrica en el 92% de los ninos, la gastrostomia en el 5% y la sonda nasoyeyunal en el 3%. El modo de alimentacion mas frecuentemente utilizado fue la administracion exclusivamente nocturna en el 39% de los casos. El soporte de modo continuo se realizo en el 32%. La dieta polimerica pediatrica se empleo en el 70% de los pacientes. Los datos antropometricos, a excepcion de la talla, mejoraron de forma significativa tras la aplicacion del soporte. El 33% de los pacientes mostraban un indice de Waterlow inicial ≥ 90%.Metodo: Se realizo una busqueda de GPC disponibles en Internet en New Zeland Guidelines Group, Nacional Institute for Clinical Excellence, Scottish Intercollegiate Guidelines Network, Canadian Medical Association Infobase, Health Services/Technology Assesment, Fisterra y Medline. Se incluyeron ademas las direcciones de la ASPEN y la SENPE. Se recuperaron todas aquellas guias editadas o actualizadas en los ultimos cinco anos, en idioma ingles o castellano.Resumen es: Las enfermedades cardiovasculares representan la primera causa de muerte en Venezuela desde el ano 1967. Existen evidencias que demuestran que la lesion ...Material y metodo: Estudio retrospectivo. Cuando existe indicacion de administrar nutricion enteral en intestino, las enfermeras de nuestra Unidad colocan este tipo de sonda en la misma habitacion del enfermo, segun tecnica descrita por el fabricante. Despues de 24 horas de su colocacion, y sin fijarla en el ala de la nariz durante este tiempo, se realiza una radiografia de abdomen en decubito supino para valorar la situacion de la punta de la sonda (gastrica vs intestinal). Si no progresa a intestino, se reajusta la longitud introducida de la sonda y se repite la radiografia en las siguientes 24 horas. Ninguno de los pacientes tenian ventilacion asistida o sedo-relajacion. El exito en la colocacion se expresa como porcentaje de paso a traves del piloro.Introduction: Significant malnutrition exists in a high percentage of patients with head and neck cancer. Malnutrition is associated with defects in immune function that may impair the host response to malignancy. Malnutrition and immunosupression make patients highly susceptible to postoperative infections and complications. Objectives: Compare two immunoenhanced enteral nutritions with a control diet, and evaluate the effect in postoperative infections, length of stay and inflammatory markers. Patients: A population of 44 patients with oral and laryngeal cancer was enrolled in a randomized trial. At surgery, patients were randomly allocated to three groups: (group I); patients receiving an arginine-enhanced formula (group II); patients receiving a standard polymeric formula, and (group III) patients receiving an arginine, RNA and omega-3 fatty acids enhanced formula, in an isonitrogenous way. Results: The duration of enteral nutrition in the three groups was similar with an average duration of 14,5 ± 8 days. The length of postoperative stay was similar, with an average of 19,8 ± 8,5 days. Wound infections and general infections were more frequent in the control group. Fistula rates were not improved in the enhanced diet groups. No significant intergroup differences in the trend of the two plasma proteins (albumin, transferrin), lymphocytes, weight, IL-6, CPR and TNFα were detected. The control group showed the highest levels of TNFα at the fourteenth postoperative day. Gastrointestinal tolerance and diarrhoea rate were similar in all the patients. Conclusions: Immunoenhanced enteral nutrition formulas improved the infection rate in the postoperative of head and neck cancer patients. In the fistula rates, we observed that technical problems and nutritional status might have played an equally important role, and therefore the positive effect of immunonutrition in this parameter might have been overestimated.Introduction: Due to the high prevalence of overweight and obesity, new strategies are needed for its prevention and treatment. Nutritional Coaching (NC) has been shown to be effective in weight reduction, even though the innovation of this concept, it’s not always used properly. Objective: To verify if NC, added to dietary assessment, is an effective approach for weight loss in overweight or obese population, compared with only technical dietary assessment. Methodology: We performed a search for papers related to NC to establish quality parameters for this intervention. A systematic review was conducted, including randomized controlled trials that apply CN according to the selected parameters and comparing it with technical dietary assessment. Results: Eight high quality studies were included in the analysis. Among these, six revealed statistical differences on behalf of the group that received NC. Conclusion: Nutritional Coaching is an effective approach for weight reduction. Future nutritional coaching intervention research would benefit from clear definitions of this new model.Introducción: El control de calidad es fundamental en cualquier intervención de enfermería clínico-asistencial y más aun en el paciente crítico. El protocolo de Enfermería de Nutrición Parenteral Total (NPT), que incluye el cambio de bolsa de nutrición, equipo de perfusión y cuidado del catéter venoso central (CVC) define unas actividades básicas. Fundamentamos el seguimiento en dos aspectos principales: 1. El paciente tiene un potencial de complicaciones relacionadas con la inserción del CVC y su manipulación, y 2. las repetidas manipulaciones de la conexión del CVC al equipo durante el tratamiento puede incidir en las infecciones del mismo.Material y metodo: Se estudiaron 27 pacientes (16 hombres y 11 mujeres) con carcinoma de colon y una edad media de 62,1 anos ? 11,2 (M?DE), de los cuales un 59% estaban en un estadio III de la enfermedad. De los pacientes incluidos, 11 habian recibido tratamiento quimioterapico previo y 16 no. El protocolo de Oncologia supuso la administracion aislada de 5fluoracilo en el 80% de los pacientes combinado con Oxaliplatino en un 17%. En todos los casos se registraron parametros antropometricos y analiticos (hemograma completo, glucosa, creatinina, bilirrubina, ALAT, ASAT, fosfatasa alcalina, albumina y marcadores tumorales) determinados antes de la cirugia y al final de la nutricion parenteral. Para evaluar la posible influencia del soporte nutricional los pacientes fueron divididos en dos grupos, en funcion de si habian o no recibido tratamiento citostatico previo a la intervencion. El analisis estadistico se realizo con el test ?2 y el de Wilcoxon (SPSS 10.0), aceptandose un nivel de significacion estadistica para p < 0,05.

Weight loss and nutritional anemia in patients submitted to Roux-en-Y gastric bypass on use of vitamin and mineral supplementation

Background/Aims: To determine the influence of the Pro12Ala polymorphism of the PPARγ2 gene and the dietary lipid intake on energy metabolism and nutritional outcomes in obese women after an acute fat load or following a low-calorie diet for 10 weeks. Methods: Sixty obese women (aged 30–46 years) participated in the study and were assigned to 2 groups depending on the genotype: Pro12Pro and Pro12Ala/Ala12Ala carriers. At baseline and after 2 nutritional (short- or long-term) interventions, measurement of anthropometrical and body composition (bioelectrical impedance) variables, dietary assessments, energy metabolism (indirect calorimetry) measurements as well as biochemical and molecular (PPARγ2 genotype) analyses were performed. All women received a high-fat test meal to determine the postprandial metabolism (short term) and an energy-restricted diet for 10 weeks (long term). Results: The frequencies of the Pro12Pro and Pro12Ala/Ala12Ala genotypes were 83.33 and 16.67%, respectively, and reached Hardy-Weinberg equilibrium. Interestingly, the postprandial energy expenditure after the fat load was higher in subjects carrying the Ala allele. At baseline, the habitual monounsaturated fatty acid (MUFA) intake inversely correlated with fat oxidation and body mass index in the obese Pro12Ala/Ala12Ala carriers, while a lower PUFA intake (%) in the long-term trial was associated with an increase in the respiratory quotient only in Ala carriers but not in the Pro12Pro genotyped group. Conclusions: The Pro12Ala polymorphism in the PPARγ2 gene influenced energy metabolism in the assayed short- and long-term situations since the response to both nutritional interventions differed according to the genotype. The results suggest that fat oxidation and energy expenditure may be lower in Pro12Pro carriers compared to Pro12Ala/Ala12Ala genotypes, while in obese women with Pro12Ala/Ala12Ala polymorphisms in the PPARγ2 gene fat oxidation was negatively correlated with the MUFA and PUFA (%) intake.

Perda ponderal e presença de anemias carenciais em pacientes submetidos à bypass gástrico em Y-de-roux em uso de suplementação de vitaminas e mine

Background Obesity is a chronic disease with high growth in population and bariatric surgery is currently considered the most effective treatment for weight reduction; on the other hand, nutritional deficiencies are observed after this procedure. Aim To analyze weight loss progression and nutritional anemia in patients submitted to Roux-en-Y gastric bypass on use of vitamin and mineral supplementation. Methods Retrospective analysis of 137 patients of both sexes, aged between 18-60 years, using supplemental multivitamins and minerals, were included; personal information, anthropometric and laboratory data in the preoperative, 12, 24, 36 and 48 months postoperatively were collected. Results Postoperatively, in both sexes, occurred weight loss compared to the pre-operative weight gain at 48 months and maintenance of body mass index. There was a decrease in the percentage of excess weight loss at 48 months postoperatively compared to the time of 12, 24 and 36 months in men and decreased at 48 postoperative months compared to the time of 24 months in females. There was a decreased in serum ferritin in both sexes and increased serum iron at 48 months postoperatively in males. There was a decreased in vitamin B12 and folic acid increased serum at 48 postoperative months in females. Conclusions Surgical treatment was effective for reducing weight, body mass index reduction and achievement of success in the late postoperative period along with multivitamin and mineral supplementation on prevention of serious nutritional deficiencies and anemia.

Impact of advanced and basic carbohydrate counting methods on metabolic control in patients with type 1 diabetes

RACIONAL: A obesidade e doenca cronica com elevado crescimento na populacao. A cirurgia bariatrica e considerada o tratamento mais efetivo para reducao de peso; por outro lado, deficiencias nutricionais sao observadas apos esse procedimento. OBJETIVO: Avaliar a evolucao da perda ponderal e a presenca de anemias carenciais em pacientes submetidos ao bypass gastrico em Y-de-Roux em uso de suplementacao de vitaminas e minerais. METODOS: Analise retrospectiva de 137 pacientes de ambos os sexos, com idade entre 18-60 anos, em uso de suplementacao de polivitaminas e minerais incluindo informacoes pessoais, dados antropometricos e laboratoriais nos periodos pre-operatorio, 12, 24, 36 e 48 meses de pos-operatorio. RESULTADOS: No pos-operatorio, em ambos os sexos, ocorreu perda de peso em relacao ao pre-operatorio, ganho de peso aos 48 meses e manutencao do indice de massa corporal. Houve diminuicao do percentual de perda de excesso de peso aos 48 meses pos-operatorios comparado com os tempos 12, 24 e 36 meses em homens e diminuicao aos 48 meses pos-operatorios em relacao aos 24 meses no sexo feminino. Houve diminuicao da ferritina serica em ambos os sexos e aumento do ferro serico aos 48 meses pos-operatorio no sexo masculino. Houve diminuicao da vitamina B12 e aumento do acido folico sericos aos 48 meses do pos-operatorio no sexo feminino. CONCLUSOES: O tratamento cirurgico mostrou-se eficaz para reducao de peso, reducao do indice de massa corporal e alcance do sucesso no pos-operatorio tardio juntamente com a suplementacao de polivitaminico e minerais na prevencao de deficiencias nutricionais importantes e anemias.

Nutritional profile of patients in a multidisciplinary treatment program for severe obesity and preoperative bariatric surgery

OBJECTIVE Diets based on carbohydrate counting remain a key strategy for improving glycemic control in patients with type 1 diabetes. However, these diets may promote weight gain because of the flexibility in food choices. The aim of this study was to compare carbohydrate counting methods regarding anthropometric, biochemical, and dietary variables in individuals with type 1 diabetes, as well as to evaluate their knowledge about nutrition. METHODS Participants were allocated in basic or advanced groups. After 3 mo of the nutritional counseling, dietary intake, anthropometric variables, lipemia, and glycemic control were compared between groups. A questionnaire regarding carbohydrate counting, sucrose intake, nutritional knowledge, and diabetes and nutrition taboos also was administered. RESULTS Ten (30%) participants had already used advanced carbohydrate counting before the nutritional counseling and these individuals had a higher body mass index (BMI) (P < 0.01) and waist circumference (WC) (P = 0.01) than others (n = 23; 69.7%). After 3 mo of follow-up, although participants in the advanced group (n = 17; 51.52%) presented higher BMI (P < 0.01) and WC (P = 0.03), those in the basic group (n = 16; 48.48%) showed a higher fat intake (P < 0.01). The majority of participants reported no difficulty in following carbohydrate counting (62.5% and 88% for basic and advanced groups, respectively) and a greater flexibility in terms of food choices (>90% with both methods). CONCLUSIONS Advanced carbohydrate counting did not affect lipemic and glycemic control in individuals with type 1 diabetes, however, it may increase food intake, and consequently the BMI and WC, when compared to basic carbohydrate counting. Furthermore, carbohydrate counting promoted greater food flexibility.

Systematic review; nutritional therapy in gestational diabetes mellitus

Background Along with the augmentation in obesity rates in recent years, the demand for bariatric surgery has startlingly increased. Nutritional counseling in the preoperative period is very important because it contributes to higher success rate in the post-operative period. Aim To assess the nutritional status of patients in a multidisciplinary program for the treatment of severe obesity and pre-operatively for bariatric surgery, characterizing the consumption of healthy nutrients. Methods A retrospective analysis of 30 patients was conducted. Personal information, anthropometric data and dietary assessment by 24-hour food record were collected. The analysis of energy intake was performed in Dietpro 5.1 Professional® program. The statistical treatment of the caloric intake was performed by an ANOVA test with Bonferronis post hoc and for anthropometric data the paired t test was used. Results From the total, 73% of the patients were women and 27% male, mean age was 48.4+12.9 and 49.8+8.1, respectively. A lower weight in the 5th appointment was observed when compared with the 1st one. There was a reduction in caloric intake in the 2nd, 3rd, 4th and 5th appointments when compared with the 1st. It was observed that in the 5th appointment more than 50% of the patients underwent six meals a day. There was an increase in the consumption of fruit along the appointments and 72.2% of patients consumed 1-2 servings of fruit a day. Vegetables intake was high in all appointments in the pre-operative period and, although low, the whole grain products consumption has increased during the pre-operative period achieving 30% of the study population. Conclusion There was a decrease in body weight, a trend in the decrease of the body mass index and waist circumference and quantitative and qualitative improvement of food consumption.