Elif Sargin Altunok

Evaluation of hepatitis B virus transmission and antiviral therapy among hepatitis B surface antigen-positive pregnant women

The aim of the present study was to assess the potential risk of hepatitis B virus (HBV) vertical transmission among Turkish parturient women and to evaluate the efficacy and safety of antiviral agents.

Protease Inhibitors Drug Resistance Mutations in Turkish Patients with Chronic Hepatitis C

BACKGROUND Drug resistance development is an expected problem during treatment with protease inhibitors (PIs), this is largely due to the fact that Pls are low-genetic barrier drugs. Resistance-associated variants (RAVs) however may also occur naturally, and prior to treatment with Pls, the clinical impact of this basal resistance remains unknown. In Turkey, there is yet to be an investigation into the hepatitis C (HCV) drug associated resistance to oral antivirals. MATERIALS AND METHODS 178 antiviral-naïve patients infected with HCV genotype 1 were selected from 27 clinical centers of various geographical regions in Turkey and included in the current study. The basal NS3 Pls resistance mutations of these patients were analyzed. RESULTS In 33 (18.5%) of the patients included in the study, at least one mutation pattern that can cause drug resistance was identified. The most frequently detected mutation pattern was T54S while R109K was the second most frequently detected. Following a more general examination of the patients studied, telaprevir (TVR) resistance in 27 patients (15.2%), boceprevir (BOC) resistance in 26 (14.6%) patients, simeprevir (SMV) resistance in 11 (6.2%) patients and faldaprevir resistance in 13 (7.3%) patients were detected. Our investigation also revealed that rebound developed in the presence of a Q80K mutation and amongst two V55A mutations following treatment with TVR, while no response to treatment was detected in a patient with a R55K mutation. CONCLUSION We are of the opinion that drug resistance analyses can be beneficial and necessary in revealing which variants are responsible for pre-treatment natural resistance and which mutations are responsible for the viral breakthrough that may develop during the treatment.

ENFEKSİYÖZ MONONÜKLEOZU TAKLİT EDEN BİR AKUT MYELOİD LÖSEMİ OLGUSU

Mononukleoz sendromunun en sik sebebi Epstein-Barr Virus (EBV) enfeksiyonudur. EBV’ nin neden oldugu enfeksiyoz mononukleoz, bogaz agrisi, ates, lenfadenopati klinigi ve serolojik olarak heterofil antikorlarin varligi ile karakterizedir. Ancak mononukleoz benzeri tabloya neden olan bircok viral enfeksiyon oldugu gibi enfeksiyon disi nedenler de vardir. Bunlardan biri de hematolojik malignitelerdir. Bu makalede; ates, bogaz agrisi, yutma guclugu, boyunda sislik klinigi olan, periferik yaymasinda atipik lenfositler ve heterofil antikor pozitifligi ile enfeksiyoz mononukleozu taklit eden bir akut myeloid losemi olgusu sunulmaktadir.