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Elijah H. Gold

Schering-Plough

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Featured researches published by Elijah H. Gold.

Pharmacy World & Science | 1982

Angiotensin-converting enzyme inhibitors

Elijah H. Gold; Bernard R. Neustadt; Elizabeth M. Smith

Inhibition of angiotensin converting enzyme (scace) in patients suffering from renovascular hypertension results in lowering of the blood-pressure. The development of captopril, an orally activeace inhibitor and the structure-activity relationship of captopril analogues are described. Some side effects of captopril were attributed to the presence of an SH-group in the molecule. This led to the development of a series of non-mercaptoace inhibitors derived from captopril. One of them, enalapril, a potentace inhibitor with a long duration of antihypertensive action, is now tested in clinical trials.

Archive | 1981

Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them

Elizabeth M. Smith; Joseph Theodore Witkowski; Ronald J. Doll; Elijah H. Gold; Bernard R. Neustadt; Albert Solomon Yehaskel

Journal of Medicinal Chemistry | 1988

Synthesis and pharmacological activity of angiotensin converting enzyme inhibitors: N-(mercaptoacyl)-4-substituted-(S)-prolines.

Elizabeth M. Smith; Gerald F. Swiss; Bernard R. Neustadt; Elijah H. Gold; Jane A. Sommer; Arthur Brown; Peter J.S. Chiu; Rosa Moran; Edmund J. Sybertz; Thomas Baum

Journal of Medicinal Chemistry | 1982

Synthesis and comparison of some cardiovascular properties of the stereoisomers of labetalol.

Elijah H. Gold; Wei Chang; Marvin P. Cohen; Thomas Baum; Stewart Ehrreich; Gordon Johnson; Nicholas Prioli; Edmund J. Sybertz

Journal of Organic Chemistry | 1972

Reductive cleavage of sulfonamides with sodium bis(2-methoxyethoxy)aluminum hydride

Elijah H. Gold; Esther Babad

Archive | 1987

Carboxyalkyl dipeptides and medical use thereof in treating hypertension and congestive heart failure

Elijah H. Gold; Bernard R. Neustadt; Elizabeth M. Smith

Archive | 1987

Carboxyalkyl dipeptides and anti-hypertensive use thereof

Elijah H. Gold; Bernard R. Neustadt; Elizabeth M. Smith

Archive | 1982

7-Carboxyalkylaminoacyl-1,4-dithia-7-azaspiro[4.4]-nonane-8-carboxylic acids

Elijah H. Gold; Bernard R. Neustadt; Elizabeth M. Smith

Journal of Medicinal Chemistry | 1989

Angiotensin converting enzyme inhibitors: spirapril and related compounds

Elizabeth M. Smith; Gerald F. Swiss; Bernard R. Neustadt; Paul McNamara; Elijah H. Gold; Edmund J. Sybertz; Thomas Baum

Journal of Medicinal Chemistry | 1981

Gastric antisecretory agents. 2. Antisecretory activity of 9-[(aminoalkyl)thio]-9H-xanthenes and 5-[(aminoalkyl)thio]-5H-[1]benzopyrano[2,3-b]pyridines.

James A. Bristol; Elijah H. Gold; Irwin Gross; Raymond G. Lovey; James F. Long

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Bernard R. Neustadt

Arthur D. Little

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Elizabeth M. Smith

Merck

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Joel G. Berger

Schering-Plough

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Wei K. Chang

Duke University

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Ronald J. Doll

Schering-Plough

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Esther Babad

Schering-Plough

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John W. Clader

Schering-Plough

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Wei Kong Chang

Schering-Plough

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Lydia Peer

Schering-Plough

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Wei Chang

Schering-Plough

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