Elisa Pianigiani

A new model of epidermal culture for the surgical treatment of vitiligo.

Background Vitiligo can be successfully treated with grafts of autologous cultured epidermal cells.

Rothmund-Thomson Syndrome (Thomson-Type) and Myelodysplasia

Rothmund–Thomson syndrome (RTS) is a genetic disease characterized by developmental abnormalities and poikilodermatous skin changes that appear in infancy. An association with myelodysplastic syndromes is rarely reported in RTS, even though impairment of immune function and recurrent infections are described in the literature. A case of Thomson‐type RTS in a 14‐year‐old girl with trilinear myelodysplasia is presented. The patient was kept under hematologic surveillance for myelodysplastic syndrome. Bone marrow transplantation was considered unnecessary at present.

Congenital Subcutaneous Granuloma Annulare

Abstract:  Granuloma annulare is a palisading granulomatous skin disease which may be generalized, localized, perforating, or subcutaneous. Subcutaneous granuloma annulare is self‐limiting, affecting infants and children, with typical postnatal onset. Here we report a patient with congenital clinical manifestations.

A new surgical approach for the treatment of severe epithelial skin sun‐induced damage

Background  Cutaneous photoageing is a complex biological process affecting all layers of the skin. Skin damage resulting from intrinsic ageing and extrinsic photoageing may trigger skin cancer. In patients with advanced photoageing and/or diffuse actinic damage, local therapy is often inadequate and the possibility of combined therapy needs to be assessed.

Intraoperative skin expansion in emergency repair of the scalp.

We report the case of a road accident victim who sustained fracture of the frontal bone and extensive skin loss. Immediate repair of the skin breach was necessary to protect the set bone fragments. Intraoperative skin expansion provided an immediate gain in tissue and avoided the waiting period required with traditional expansion methods. Besides an excellent immediate functional result, acceptable aesthetic results, confirmed 6 months later, were also obtained. ( J Dermatol Treat (2001) 12: 25-28)

Two cases of juvenile pemphigus vulgaris: long‐term follow‐up

patients (2). Our patient, of necessity, spent a prolonged period with his head in the same position in the ICU because of cerebral edema. This resulted, in pressure-induced ischemic changes over the scalp occiput. Although the hair loss was perhaps minor, it is likely to be permanent and may lead to embarrassment in the future. Such alopecia is preventable by regularly moving the position of the head during and after general anesthesia or immobilization; however, regular movements may not always be practical. We believe that such hair lossmay not be uncommon, but is often unrecognized. A pertinent reason for the latter is that an occipital bald patch may remain unnoticed until long after a period of immobilization so that such an etiology may not even be considered.

Juvenile pemphigus vulgaris: efficacy of moderate doses of deflazacort.

Abstract: A 13‐year‐old girl with pemphigus vulgaris (PV) had clinical features of chronic stomatitis. The histologic and immunologic findings were typical of a diagnosis of PV. Good therapeutic results were obtained with moderate doses of deflazacort, 1 mg/kg/day slowly tapered to 0.1 mg/kg every other day. The patient had no significant side effects.

SNHG5 promotes proliferation and induces apoptosis in melanoma by sponging miR-155

Background: Melanoma is the most common malignancy of skin cancer. Small nucleolar RNA host gene 5 (SNHG5), a long non-coding RNA (lncRNA), has been demonstrated to be abnormally expressed in multiple malignances. However, the roles and molecular mechanisms of SNHG5 in melanoma progression have not been well identified. Methods: RT-qPCR assays were used to detect the expression patterns of SNHG5 and microRNA-155 (miR-155). Cell proliferation was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and colony formation assays. Cell apoptosis rate was measured by flow cytometry via double-staining of fluorescein isothiocyanate (FITC)-labeled annexin V (Annexin V-FITC) and propidium iodide (PI). The interaction between SNHG5 and miR-155 was validated using bioinformatics analysis, subcellular fraction assay, luciferase assay and RNA immunoprecipitation (RIP) assay. A mouse model of melanoma was established to further verify the effect of SNHG5 on tumor growth in vivo. Results: SNHG5 expression was upregulated in melanoma tumor tissues and cell lines. Moreover, higher SNHG5 expression was associated with advanced pathogenic status and poor prognosis. Functional analysis showed that SNHG5 knockdown suppressed proliferation and facilitated apoptosis in melanoma cells. Mechanical exploration revealed that SNHG5 acted as a molecular sponge of miR-155 in melanoma cells. Restoration experiments delineated that miR-155 down-regulation partly abrogated SNHG5-knockdown-mediated anti-proliferation and pro-apoptosis effect in melanoma cells. In vivo assays further demonstrated that SNHG5 depletion hindered tumor growth through up-regulating miR-155 expression. Conclusion: SNHG5 promoted the development of melanoma by sponging miR-155 in vitro and in vivo, implying the important implication of lncRNAs in melanoma progression and providing a potential therapeutic target for melanoma.

Pyemotes ventricosus detection in a baby skin folds

A 20-month-old healthy baby was referred during the summertime for a 15 and 20 days-history of two erythematous scaling patches of the axillar (fig.1a) and popliteal (fig.1b) folds, respectively, slightly itching at onset. The clinical history was mute except for contacts with cats in the last months and anti-Meningococcal vaccination one month before, followed by fever and transient erythema of the chest. This article is protected by copyright. All rights reserved.

Current insights into skin banking: storage, preservation and clinical importance of skin allografts

php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). Journal of Biorepository Science for Applied Medicine 2017:5 41–56 Journal of Biorepository Science for Applied Medicine Dovepress