Elisa Rojas

Ultraviolet light exposure and skin cancer in the city of Arica, Chile

An increase in the amount of solar ultraviolet light that reaches the Earth is considered to be responsible for the worldwide increase in skin cancer. Solar ultraviolet B (UVB) light (290-320 nm) has multiple effects that can be harmful to human beings. The city of Arica in Chile receives high UV levels. This can explain the high prevalence of skin cancer in the Arica population. In the present study, pathological reports of skin cancer were collected from an Arica hospital and retrospectively examined to investigate the possible effects of UV radiation. Among the malignant skin tumor types, basocellular and spinocellular carcinomas were more common in men (44.4 and 16.6%, respectively) than in women (24.9 and 10.7%, respectively). Basocellular carcinoma was observed in individuals 40-79 years of age. The incidence of skin cancer significantly increased (P<0.05) between 2000 and 2006 per 100,000 population. The factor of incidence of skin cancer per 100,000 population significantly increased (P<0.05) between 1980 and 2000 in both genders, but was higher in men (0.79-1.99) than in women (0.63-1.56). The results of the study indicate a steady increase in the incidence of skin cancer in Arica, Chile, most probably due to the high levels of ultraviolet light to which individuals are exposed throughout the year, and the cumulative effect of this type of radiation on the skin.

EFECTO DE LA ALTURA EN LA RADIACIÓN SOLAR ULTRAVIOLETA EN ARICA NORTE DE CHILE

In this work, using transfer radiative models, we present results obtained when calculating the levels of solar ultraviolet radiation that reach Arica at sea level, as well as altitudes of 4.500 m above sea level. (Lat.: 18o 49’ S; Long. 70o 19’ W). The level of solar ultraviolet radiation that reaches the earth varies due to multiple factors, such as the geographical location (latitude), the thickness of the ozone layer present above, the cloud cover and the altitude above sea level. Locations at both sea level and at 4500 m above sea level can be found in northern Chile. These locations are specially adequate for the study of the effects of altitude in the increase of solar ultraviolet radiation. This topic is relevant because a great number of people, having jobs related to copper mining and tourism, who often travel moving from places that are located at sea level to settings that are situated at 5000 m above sea level, are exposed to significantly increased solar ultraviolet radiation.

Skin cancer risk affected by ultraviolet solar irradiance in Arica, Chile

The present study analyzed the risk of skin cancer due to ultraviolet erythemal irradiance (UVery) in Arica, Chile, using measurements of the solar ultraviolet index (UVI) between 2006 and 2011. The daily maximum value by biometer Yankee Environmental Systems (YES) solar ultraviolet B (UVB)-1 was measured between 2007 and 2012, and seasonal variations were clearly observed, with higher UVI levels during the summer when UVI usually reached extreme values of >11. The maximum UVI value was 15.6 in the summer of 2008 and the minimum was 2.2 in the winter of 2008. The UVI mean values that were collected monthly at noon between 2006 and 2010 fluctuated between 13 and 6, and reached higher values in January and lower values in June and July. Thus, a seasonal UVI response was observed during the two seasons. The accumulated UVery/day was calculated between September 2006 and 2007, the time when Arica normally receives the highest UVI levels. It was also noted that 60% of the days in September demonstrated values of >3.41 kJ/m2/day, while 3.3% of cloudy days had values of <2.0 kJ/m2/day. The mean value of UVery during 2007 was 3.23 kJ/m2/day and the variation was 1.9–4.6 kJ/m2/day. These UVery values were several times higher than the minimal erythemal doses (MEDs) corresponding to the skin types most frequently observed in Chile, skin types III and IV. The MED for skin type IV was 0.60 kJ/m2. The results demonstrated that the skin cancer rate was increased due to the fact that individuals from Arica are exposed to several times more UVery than the MED for their skin type during the spring and summer seasons.

Association between non‑melanoma and melanoma skin cancer rates, vitamin D and latitude

Vitamin D synthesis takes place in the skin due to solar ultraviolet-B (UVB) radiation. Several studies have shown the association between low sun exposure, non-melanoma skin cancer (NMSC) and a lack of vitamin D synthesis. Since such synthesis in the body depends on the exposure of the skin to solar UVB radiation (290-320 nm), experimental measurements of this type of solar radiation are important. Tarapaca University in Arica, Chile, established a solar UV radiation laboratory in 2006 and since then this laboratory has performed systematic experimental solar UVB measurements using a calibrated biometer instrument. The results, which are presented in the current study, showed the association between NMSC and MSC rates, and the time required to produce 1,000 IU vitamin D with latitudinal variation. Solar UV index (UVI) levels reported in 6 cities from the north to the south of Chile indicated that the UVI ratio of monthly mean values was 1.8 times higher in Arica than in Punta Arenas in January (summer in Chile), whereas it was 14 times higher in June (winter). This factor is an important consideration, since vitamin D synthesis is directly associated with the exposure of individuals to solar UVB radiation. A similar trend was observed in Antofagasta, Santiago, Concepcion, Valdivia and Punta Arenas. It can be concluded from these data that there is a direct association between NMSC rates and mortality, and UVB radiation, meaning that this type of cancer would not depend on vitamin D synthesis and therefore on calcium uptake. By contrast, MSC rates increased with decreased levels of vitamin D, and thus calcium uptake, in all cities, with the only exception being Punta Arenas.