Elisabeth Bock
University College Dublin
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Publication
Featured researches published by Elisabeth Bock.
Journal of Neurochemistry | 2002
Andrew G. Foley; Barbara P. Hartz; Helen C. Gallagher; Lars C.B. Rønn; Vladimir Berezin; Elisabeth Bock; Ciaran M. Regan
Abstract: The neural cell adhesion molecule (NCAM) mediates cell adhesion and signal transduction through trans‐homophilic‐ and/or cis‐heterophilic‐binding mechanisms. Intraventricular infusions of anti‐NCAM have revealed a functional requirement of NCAM for the consolidation of memory in rats and chicks in a specific interval 6‐8 h after training. We have now extended these studies to a synthetic peptide ligand of NCAM (C3) with an affinity for the IgI domain and the capability of inhibiting NCAM‐mediated neurite outgrowth in vitro. Intraventricular administration of a single 5 μg bolus of C3 strongly inhibited recall of a passive avoidance response in adult rats, when given during training or in the 6‐8‐h posttraining period. The effect of C3 on memory consolidation was similar to that obtained with anti‐NCAM as the amnesia was not observed until the 48‐h recall time. The unique amnesic action of C3 during training could be related to disrupted NCAM internalization following training. In the 3‐4‐h posttraining period NCAM 180, the synapse‐associated isoform, was down‐regulated in the hippocampal dentate gyrus. This effect was mediated by ubiquitination and was prevented by C3 administration during training. These findings indicate NCAM to be involved in both the acquisition and consolidation of a passive avoidance response in the rat. Moreover, the study provides the first in vivo evidence for NCAM internalization in learning and identifies a synthetic NCAM ligand capable of modulating memory processes in vivo.
Archive | 2003
Vladimir Berezin; Elisabeth Bock; Morten Albrechtsen
Archive | 1999
Lars Christian B. Rønn; Elisabeth Bock; Arne Holm; Marianne Olsen; Soren Ostergaard; Peter H. Jensen; Flemming M. Poulsen; Vladislav Soroka; Igor Ralets; Vladimir Berezin
Archive | 2004
Morten Albrechtsen; Elisabeth Bock; Vladimir Berezin; Arne Holm
Archive | 2002
Vladislav V. Kiselyov; Galina Skladchikova; Vladimir Berezin; Elisabeth Bock
Archive | 2012
Vladimir Berezin; Elisabeth Bock
Archive | 2006
Elisabeth Bock; Vladimir Berezin; Darya Kiryushko
Archive | 2005
Elisabeth Bock; Vladimir Berezin
Archive | 2006
Vladimir Berezin; Elisabeth Bock
Archive | 2007
Elisabeth Bock; Vladimir Berezin; Vladislav V. Kiselyov