Elizabeth A. Day

Dynamics of T cell memory in human cytomegalovirus infection

Primary human cytomegalovirus (HCMV) infection of an immunocompetent individual leads to the generation of a robust CD4+ and CD8+ T cell response which subsequently controls viral replication. HCMV is never cleared from the host and enters into latency with periodic reactivation and viral replication, which is controlled by reactivation of the memory T cells. In this article, we discuss the magnitude, phenotype and clonality of the T cell response following primary HCMV infection, the selection of responding T cells into the long-term memory pool and maintenance of this memory T cell population in the face of a latent/persistent infection. The article also considers the effect that this long-term surveillance of HCMV has on the T cell memory phenotype, their differentiation, function and the associated concepts of T cell memory inflation and immunosenescence.

GrowYourIC: A Step Toward a Coherent Model of the Earth's Inner Core Seismic Structure

A complex inner core structure has been well-established from seismic studies, showing radial and lateral heterogeneities at various length scales. Yet, no geodynamic model is able to explain all the features observed. One of the main limits for this is the lack of tools to compare seismic observations and numerical models successfully. We use here a new Python tool called GrowYourIC to compare models of inner core structure. We calculate properties of geodynamic models of the inner core along seismic ray paths, for random or user-specified datasets. We test kinematic models which simulate fast lateral translation, super-rotation, and differential growth. We explore first the influence on a real inner core data set, which has a sparse coverage of the inner core boundary. Such a data set is however able to successfully constrain the hemispherical boundaries due to a good sampling of latitudes. Combining translation and rotation could explain some of the features of the boundaries separating the inner core hemispheres. The depth shift of the boundaries, observed by some authors, seems unlikely to be modelled by a fast translation, but could be produced by slow translation associated to super-rotation.

Compositional heterogeneity near the base of the mantle transition zone beneath Hawaii

Global seismic discontinuities near 410 and 660 km depth in Earth’s mantle are expressions of solid-state phase transitions. These transitions modulate thermal and material fluxes across the mantle and variations in their depth are often attributed to temperature anomalies. Here we use novel seismic array analysis of SS waves reflecting off the 410 and 660 below the Hawaiian hotspot. We find amplitude–distance trends in reflectivity that imply lateral variations in wavespeed and density contrasts across 660 for which thermodynamic modeling precludes a thermal origin. No such variations are found along the 410. The inferred 660 contrasts can be explained by mantle composition varying from average (pyrolitic) mantle beneath Hawaii to a mixture with more melt-depleted harzburgite southeast of the hotspot. Such compositional segregation was predicted, from petrological and numerical convection studies, to occur near hot deep mantle upwellings like the one often invoked to cause volcanic activity on Hawaii.Seismic discontinuities near 410 and 660 km depth have often been used to map lateral variations in mantle temperature. Here, the authors apply array analysis to SS reflections off these discontinuities under Hawaii and find evidence of lateral variations in mantle composition at 660 km, but not at 410 km.

Mapping Mantle Transition Zone Discontinuities Beneath the Central Pacific With Array Processing of SS Precursors: Array Analysis of MTZ Discontinuities

We image mantle transition zone (MTZ) discontinuities beneath the Central Pacific using ~120,000 broadband SS waveforms. With a wave packet-based array processing technique (curvelet transform), we improve the signal-to-noise ratio of SS precursors and remove interfering phases, so that precursors can be identified and measured over a larger distance range. Removal of interfering phases reveals possible phase shifts in the underside reflection at the 660, that is, S^(660)S, which if ignored could lead to biased discontinuity depth estimates. The combination of data quantity and improved quality allows improved imaging and uncertainty estimation. Time to depth conversions after corrections for bathymetry, crustal thickness, and tomographically inferred mantle heterogeneity show that the mean depths of 410 and 660 beneath the Central Pacific are 420 ± 3 km and 659 ± 4 km, respectively. The mean MTZ thickness (239 ± 2 km) is close to global estimates and suggests an adiabatic mantle temperature of ~1,400°C for the Central Pacific. Depth variations of the 410 and 660 appear to be relatively small, with peak-to-peak amplitudes of the order of 10–15 km. The 410 and 660 are weakly anticorrelated, and MTZ is thinner beneath Hawaii and to the north and east of the hotspot and thicker southwest of it. The relatively small discontinuity topography argues against the presence of large-scale (more than 5° wide) thermal anomalies with excess temperatures over 200 K across the transition zone. The data used cannot exclude stronger thermal anomalies that are of more limited lateral extent or that are not continuous across the MTZ.