Elizabeth J. Williams
Medical University of South Carolina
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Publication
Featured researches published by Elizabeth J. Williams.
Pediatric Transplantation | 2018
Vanessa Fabrizio; Amy E. Wahlquist; Elise Hill; Elizabeth J. Williams; Cindy Kramer; Jennifer Joi Jaroscak; Angie Duong; Elizabeth Garrett-Mayer; Michelle Hudspeth
Hematopoietic stem cell graft cellular composition has been generally accepted to impact outcomes. Recent studies question this hypothesis. We conducted a single‐center retrospective study of sixty‐one pediatric BMT recipients for malignant (68%) and nonmalignant diseases (32%) examining effects of graft composition on engraftment, acute GVHD, chronic GVHD, and survival at day 100 and 1 year. Grafts contained a median of 3.63 x 08 TNC/kg (range: 0.031‐10.31 x 108 TNC/kg) and 4.09 x 106 CD34+/kg (range: 0.76‐24.15 x 106 CD34+/kg) with median neutrophil and platelet engraftment times of 17 and 29 days, respectively. A univariate analysis showed a trend for increasing TNC and increasing time to neutrophil engraftment HR: 0.875; CI: 0.075‐1.001). Increasing CD34+ counts shortened time to platelet engraftment (HR: 1.085; CI: 1.015‐1.161). No significant relationship was found between TNC, CD34+, or CD3+ and acute or chronic GVHD. TNC or CD34+ did not affect day 100, 1‐year survival, or 2‐year survival. Increasing CD3+ counts demonstrated a negative trend on day 100 survival (HR: 1.108; CI: 1.001‐1.036) but not 1‐year survival or 2‐year survival. These results add additional data questioning the effect of graft composition on outcomes in pediatric BMT patients with important ramifications for the management of donors.
Biology of Blood and Marrow Transplantation | 2018
Elizabeth J. Williams; Michelle Hudspeth; Cindy Kramer
Biology of Blood and Marrow Transplantation | 2017
Elizabeth J. Williams; Michelle Hudspeth
Biology of Blood and Marrow Transplantation | 2017
Colleen Butcher; Kathy Hogan Edwards; Michelle Hudspeth; Kristy Martin; Elizabeth J. Williams; Robert K. Stuart; Amanda Littleton; Leah Judd; Melinda Cone; Cindy Kramer
Biology of Blood and Marrow Transplantation | 2017
Cindy Kramer; Colleen Butcher; Michelle Hudspeth; Jennifer Joi Jaroscak; Robert K. Stuart; Elizabeth J. Williams; Leah Judd; Saurabh Chhabra; Amanda Littleton; Valeriy Sedov; Juan Carlos Varela; Kristy Martin; Laura Cole; Rebecca Welsh; Melinda Cone; Yolanda Williams
Biology of Blood and Marrow Transplantation | 2017
Elizabeth J. Williams; Michelle Hudspeth; Cindy Kramer
Biology of Blood and Marrow Transplantation | 2016
Elizabeth J. Williams
Biology of Blood and Marrow Transplantation | 2016
Elizabeth J. Williams
Biology of Blood and Marrow Transplantation | 2016
Ridhi Gupta; Rashmi Khanal; Mark Thomas Burbridge; Elizabeth garrett Mayer; Ellen Baldino; Colleen Butcher; Kylie Capdevil; Kathy Hogan Edwards; Carolyn Ann Gentles; Randi Hoffman; Amanda Littleton; Kristy Martin; Cindy Kramer; Molly Schneider; Valeriy Sedov; Juan Carlos Varela; Elizabeth J. Williams; Robert K. Stuart; Saurabh Chhabra
Biology of Blood and Marrow Transplantation | 2016
Mark Thomas Burbridge; Ridhi Gupta; Rashmi Khanal; Ellen Baldino; Colleen Butcher; Kylie Capdevila; Kathy Hogan Edwards; Carolyn Ann Gentles; Amanda Littleton; Kristy Martin; Cindy Kramer; Molly Schneider; Valeriy Sedov; Juan Carlos Varela; Elizabeth J. Williams; Robert K. Stuart; Saurabh Chhabra