Elvan Tabachnik

Sustained-release theophylline: A significant advance in the treatment of childhood asthma

7. Reeves DS, and Bywater M J: Assay of antimicrobiaI agents, in deLouvois J, editor: Selected topics in clinical bacteriology, London, 1976, Baili6re Tindall, pp 21-79. 8. Chamberlain J, Coombes JD, Dell D, Fromson JM, Ings R J, Macdonald CM, and McEwen J: Metabolism of cefotaxime in animals and man, J Antimicrob Chemother 6(Suppt):69, 1980. 9. Reeves DS, White, LO, Holt HA, Bahari D, Bywater M J, and Bax RP: Human metabolism of cefotaxime, J Antimicrob Chemother 6(Suppl):93, 1980. 10. Sedman A J, and Wagner JG: CSTRIP, a fortran IV computer program for obtaining initial polyexponential parameter estimates, J Pharm Sci 65:1006, 1976. 11. Metzler CM, Elfring GL, and McEwen A J: A package of computer programs for pharmacokinetic modeling, Biometrics 30:562, 1974 (abstr). 12. Boxenbaum HG, Riegelman S, and Elashoff RM: Statistical estimations in pharmacokinetics, J Pharmacokinet Biopharm 2:123, 1974. 13. Wagner JG: Linear pharmacokinetic equations allowing direct calculation of many needed pharmacokinetic parameters from the coefficients and exponents of polyexponential equation which have been fitted to the data, J Pharmacokinet Biopharm 4:443, 1976. 14. Fillastre JP, Leroy A, Humbert G, and Godin M: Pharmacokinetics of cefotaxime in subjects with normal and impaired renal function, J Antimicrob Chemother 6(Suppl):103, 1980. 15. Fu KP, Aswapokee P, Ho I, Matthijssen C, and Neu, HC: Pharmacokinetics of cefotaxime, Antimicrob Agents Chemother 16:592, 1979. t6. Luthy R, Munch R, Blaser J, Bhend H, and Siegenthaler W: Human pharmacology of cefotaxime (HR 756), a new cephalosporin, Antimicrob Agents Chemother 16:127, 1979.

Ethnic differences in lung function in Israeli children.

BACKGROUND--The population of Israel consists of immigrants from many different countries. It is not known whether a single nomogram can be used for spirometric values of children of different ethnic descent. METHODS--Spirometry was performed in 753 second or third generation Israeli children (7-14 years) of different ethnic groups. Both parents of 503 of the children were of the same ethnic background. Subjects were allocated to six ethnic groups (European, Iraqi, North African, Indian, Yemenite, and Georgian). RESULTS--Standing height contributed most to the prediction of spirometric values (forced expiratory volume in one second, forced vital capacity), whereas sitting height did not contribute further. Statistical analysis showed significant ethnic differences. The Georgians had higher spirometric values for FEV1 than all the other ethnic groups, and higher FVC values than those of the Yemenite, North African, and Indian groups. FVC was lower among the Indian than all other groups. CONCLUSION--Differences in normal spirometric values were found among second or third generation Israeli children of different ethnic origins. European, North African, Iraqi, and Yemenite children could be characterised by single equation, whereas children of Georgian and Indian descent needed different predicting equations.