Emel Aslan

Histopathological and Biochemical Effects of Ecballium elaterium on Sepsis-Induced Lung Injury

ABSTRACT Purpose: The aim of this study was to investigate the role of Ecballium elaterium (EE) on sepsis-induced lung injury. Materials and Methods: A total of 30 male rats were divided into three groups as follows: control, sepsis, and treatment groups (sepsis + EE) with each group containing 10 rats. A rat model of sepsis induced by cecal ligation and puncture (CLP) was used. In the treatment group, rats were injected intraperitoneally with 2.5 mg/kg EE after CLP. Interleukin-6 (IL-6), tumor necrosis factor (TNF)-α, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) values after a 24-hr period were measured via cardiac puncture. Animals were harvested after the procedure and biochemical analysis was done and histopathological changes of the tissue sections of lungs were examined thereafter. Results: A statistically significant decrease was observed in the IL-6 (p < .05), TNF-α (p < .05), and TOS (p < .01) levels in the sera of the treatment group compared to those of the sepsis group. Following the treatment, the TOS (p = .01) and OSI (p < .05) levels in the lung tissue of rats indicated a statistically significant decrease compared to those of the sepsis group. The histopathological follow-up undertaken after the administration of the EE treatment to septic rats showed significantly lower values of alveolar wall thickness (p < .001), interstitial edema (p = .018), and neutrophil infiltration (p = .047). Conclusion: EE treatment may have beneficial effects on sepsis-induced lung injury, and therefore has potential for clinical use.

Risk factors for colistin-associated acute kidney injury: a multicenter study from Turkey

The aim of this study was to investigate the incidence of acute kidney injury (AKI) and risk factors due to colistin use in patients infected with multidrug-resistant pathogens. This multicenter, retrospective, observational study was conducted in Turkey, at 5 different research and university hospitals. Cox regression analyses were performed, to determine independent predictors of AKI. From April 2012 to July 2014, a total of 216 patients aged between 18-94 years, treated with colistimethate sodium (CMS) were included in the study. The mean age of the patients was 60.3 ± 20.1 years. The overall incidence of AKI was 34.3% (74/216) at any time during treatment. Concomitant use of loop diuretics, baseline creatinine level, and CMS dosage were independently associated with AKI. According to our results, patients with higher baseline creatinine levels, or patients who had to use concomitant loop diuretics may need to be monitored more closely, and dose adjustment should be done promptly. More comprehensive studies are, however, still needed to evaluate the efficacy of low-dose colistin since higher doses tend to increase the risk of AKI.

Our Diabetic Foot Infections We Followed Accompanied By Alternative Methods

5-7 Mayıs 2016, İstanbul’da yapılacak olan IV. Ulusal Diyabetik Ayak İnfeksiyonları Simpozyumu’na poster olarak kabul edildi. *Sorumlu Yazar: Doç. Dr. Fatma Bozkurt, Dicle Üniversitesi Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Diyarbakır, Cep: 0 (505) 771 07 92, E-mail: drfatmayakut@hotmail.com Geliş Tarihi: 21.04.2016, Kabul Tarihi: 28.04.2016 KLİNİK ÇALIŞMA / CLINICAL RESEARCH

Chronic Viral Hepatitis-Induced Liver Cirrhosis in a Patient with Brucellosis

Brucellosis is an endemic infectious disease in our country. Clinical signs and symptoms are spread over a wide spectrum; musculoskeletal, gastrointestinal system, cardiovascular system and the genitourinary system can be affected. Elevation of transaminases is a common finding in brucellosis due to involvement of reticuloendothelial system including the liver and spleen. In the patient presented here, hepatic cirrhosis was found due to chronic hepatitis B and delta hepatitis infection in the investigations made for not to overlook viral causes that might cause transaminase elevation and it was emphasized that these possible conditions shouldn’t be overlooked in our region where brucellosis and hepatitis B are common.