Emi Ito

Relation Between the Prefrontal Cortex and Cerebro-Cerebellar Functions: Evidence From the Results of Stabilometrical Indexes

The relation between prefrontal cortex and cerebro-cerebellar functions of 50 normal healthy elderly people was examined. The function of the prefrontal cortex was measured by means of a letter fluency test and the Digit Cancellation Test (D-CAT, a test for the assessment of attention). Two indexes of postural tremor measured by the stabilometer were employed for the indication of cerebello-thalamo-cortical circuit functions. The results of groups consisting of participants showing higher or lower scores than the mean of the norm on the stabilometer index measurements were compared with their D-CAT and letter fluency test performances. The results showed that 2 indexes of cerebello-thalamo-cortical circuit functions related to the attention function while the relation to the language function was rather weak. The results of the behavioral measures demonstrated a mutual relation between prefrontal cortex and cerebello-thalamo-cortical circuit functions and strongly suggest the notion that the human brain functions as a system, which includes neocortex, subcortex, and cerebellum.

Activities with Higher Influence on Quality of Life in Older Adults in Japan

The present study aimed to investigate the influence of 10 activities on quality of life (QOL) in Japanese older adults and to verify which activities had higher influence on QOL level. The subjects were 465 Japanese community-dwelling older adults. QOL was assessed by the brief version of the World Health Organization Quality of Life (WHOQOL-BREF) and the complementary assessment to measure the QOL of older adults (WHOQOL-OLD) module. Activity and participation were measured through a questionnaire concerning frequency of engagement in several activities. The activity with the highest influence on WHOQOL-BREF was physical activity (β = 0.209, p < 0.01), followed by art activity (β = 0.169, p < 0.01) and reading and writing (β = 0.141, p < 0.01). The activity with the highest influence on WHOQOL-OLD was social activity (β = 0.222, p < 0.01), followed by reading and writing activity (β = 0.118, p < 0.05). The limitations of this study were the proportion of subjects and the place of recruitment. Further studies investigating in deep the relation between QOL and activity and participation, and other subjective and environmental factors that may influence the QOL are still needed among a higher and homogeneous subjects sample.

The relation between cognitive function and UI in healthy, community-dwelling, middle-aged and elderly people

The aim of this study was to examine the relation between UI and cognitive function among non-disabled middle-aged and elderly community-dwelling people. A total of 201 participants (86 men and 115 women) were given a structured questionnaire regarding their condition of UI as well as a cognitive assessment battery (memory, attention, verbal fluency, information processing speed, and visuospatial function). The results showed a significant relation between UI and cognitive tasks for letter fluency, attention, and information processing speed, while no relation was found in cognitive tasks for memory and visuospatial function. Based on these findings, possible mechanisms regarding the relation between UI and cognitive function, and preventive methods to reduce the prevalence of UI in middle-aged and upper middle-aged community dwellers are discussed.

Developmental trajectories of verbal and visuospatial abilities in healthy older adults: Comparison of the hemisphere asymmetry reduction in older adults model and the right hemi-ageing model

Two models of cognitive ageing, the hemisphere asymmetry reduction in older adults (HAROLD) model and the right hemi-ageing model, were compared based upon the verbal memory and visuospatial task performance of 338 elderly participants. Comparison of the developmental trajectories for four age groups (50s, 60s, 70s and 80s) supported the HAROLD model, but not the right hemi-ageing model. Performance differences between the verbal memory and visuospatial tasks in the earlier age groups decreased in the later age groups. There was a sex difference in the cognitive-decline trajectories for verbal and visuospatial task performance after the 50s.

Relations Between Exercise Habit and Visual Attentional Ability in Older Adult Community Dwellers: Evidences From the Yakumo Study:

Objective: The relation between mild everyday exercise and cognitive ability in healthy older people was examined using cohort study database. Methods: Individually calculated linear regression coefficients in digit cancelation task performances for 11 years age from 65 to 75 years were compared between mild exercise habit holders and non-holders. Results: Exercise habit holders showed significantly smaller age-related decline than non-holders, irrespective of task difficulty. Discussion: The results suggested that even mild exercise habit for long years possesses benefits on sustaining cognitive function in older people as well as the physical activities such as programmed in a sport gym. It also becomes clear that it is difficult for ordinary older adult to continue exercising habits for many years. Therefore, more substantial ways are required for local health officials to advertise the effectiveness of mild exercise habits and to devise the necessary work to become a habit.

Donor−π–Acceptor Type Unsymmetrical Triarylborane-Based Fluorophores: Synthesis, Fluorescence Properties, and Photostability

A two-step synthesis to prepare tricoordinate organoboron compounds bearing three different aryl groups has been developed. After the first aryl substitution to an aryl boronic ester took place, the intermediate species, that is, bis(diarylborinate) species, was isolated as an air- and moisture-stable solid, which allowed the second aryl substitution to carry out in a selective manner. Subsequently, a series of unsymmetrical triarylboranes possessing a sterically bulky aryl group, triarylamine moiety, and para-functionalized phenyl ring was synthesized. Not only did these triarylboranes exhibit remarkable solvent-dependent fluorescence as expected for donor-π-acceptor (D-π-A) systems, they were also accompanied by profound persistence against photoirradiation especially for that bearing a 1,3,5-tri- tert-butylphenyl ring. This survey exemplifies that sufficient electronic and steric modification is key to construct photostable D-π-A type triarylborane-based fluorophores.

Sex Difference in Cognitive Aging for Letter Fluency and Semantic Fluency

This study examined the sex difference in cognitive aging for verbal abilities. To examine developmental changes on Letter Fluency (LFT) and Semantic Fluency (SFT) tests, healthy 224 women and 139 men over 40 years old participated in this study. The results showed that performance of both sex in the 40’s and 50’s remained at the same level, but the performance declining for the LFT and the SFT after the 70’s were not parallel. For the LFT, men showed a steep decline from 50’s to 70’s, whereas women showed a gradual decline from 50’s to 80’s. For the SFT, men showed a sharp decline from 50’s to 70’s and remained at a similar level after the 70’s, whereas women did not show a steep performance decline from their 50’s to 70’s and their performance level in 70’s was the same as in 80’s.

Developmental Changes of Prefrontal Cortex and Cerebro-Cerebellar Functioning in Older Adults: Evidence from Stabilometer and Cognitive Tests

The relation between cognitive and postural functioning was examined as developmental changes among healthy older adults. The 339 participants (207 women and 132 men) of four age groups (50’s, 60’s, 70’s, and 80’s) were given the Digit Cancellation Test (D-CAT) for the assessment of prefrontal cortex related cognitive functioning, and the Logical Memory Test for the assessment of fronto-parietal cortex related cognitive functioning. The postural functioning of the participants was measured by a stabilometer for the assessment of cerebro-cerebellar related motor functioning. The results showed that the developmental changes in performances for non-automatic intentional cognitive and automatic motor postural functioning were not parallel. Cognitive functioning did not show clear sex difference while motor postural functioning showed robust sex difference. Largely, cognitive functioning DCAT and Logical Memory Test showed gradual performance decrease 23-48% for each age group from 50’s to 80’s while robust motor postural functioning performance decreased approximately 60% from 70’s to 80’s in men and approximately 65% from 60’s to 70’s in women. Based upon these findings, characteristics of age-related changes in cerebro-cerebellar brain systems in middle aged and older healthy people are discussed.