Emine Sen
University of Health Sciences Antigua
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International Journal of Ophthalmology | 2014
Mehmet Yasin Teke; Ufuk Elgin; Pinar Nalcacioglu-Yuksekkaya; Emine Sen; Pinar Ozdal; Faruk Öztürk
AIM To discuss and compare the fundus autofluorescence (FAF) and optical coherence tomography (OCT) in acute or chronic central serous chorioretinopathy (CSCR). METHODS Medical records of 100 cases of CSCR were reviewed. Acute and chronic cases were evaluated according to the duration of decreased visual acuity, serous retinal detachment (RD) and focal leakage on fluorescein angiography (FA). Chi-square test was used for statistical analysis. RESULTS Forty cases had acute and 60 cases had chronic CSCR. FAF showed focal hypo-autofluorescence in 34 (85%) and iso-autofluorescence in 6 (15%) of acute cases and hypo-autofluorescence in 51 (85%), hyper-autofluorescence in 6 (10%) and iso-autofluorescence in 3 (5%) of chronic cases. OCT showed serous RD with distinct borders correlated with FAF findings (hypo-autofluorescence) in all acute CSCR cases. In chronic CSCR group, OCT showed serous RD with indistinct borders correlated with FAF findings. The differences between the OCT and FAF findings of the two groups were significant (P=0.000). CONCLUSION OCT and FAF findings can support the clinical observations in differential diagnosis of acute and chronic CSCR and help clinicians to evaluate retinal pigment epithelium, outer segments of photoreceptors and the components of serous RD.
European Journal of Ophthalmology | 2014
Emine Sen; Yüksel Onaran; Pinar Nalcacioglu-Yuksekkaya; Ufuk Elgin; Faruk Öztürk
Purpose To evaluate the variation in biomechanical properties and central corneal thickness (CCT) for each trimester during pregnancy and to compare the values with those in nonpregnant women. Methods We prospectively studied the eyes of 32 pregnant and 34 age-matched non-pregnant women. The parameters included corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOP), and corneal-compensated IOP measured by the Ocular Response Analyzer (ORA). The CCT was also measured with an ultrasonic pachymeter attached to the ORA. Results The mean age was 27.0 ± 3.8 years in the study group and 28.0 ± 4.1 years in the control group. The mean CH measurement was 10.6 ± 1.4 mmHg in the study group and 10.1 ± 1.3 mmHg in the control group. The mean CRF value was 9.6 ± 1.7 mmHg in the study group and 10.0 ± 1.4 mmHg in the control group. The mean CCT value was 541.1 ± 22.4 μm in the study group and 536.5 ± 27.1 μm in the control group. No statistically significant differences were found regarding CH, CRF, or CCT values between the 2 groups (independent t test, p = 0.160, p = 0.355, p = 0.450, respectively). Conclusions Hormonal changes during pregnancy may not affect corneal biomechanics. This may be due to the balanced effect of the various hormones on the cornea during pregnancy.
Journal of Ocular Pharmacology and Therapeutics | 2010
Emine Sen; Melike Balikoglu-Yilmaz; Sibel Bozdag-Pehlivan; Nuran Sungu; Fatma Nur Aksakal; Ayse Altinok; Tülay Tuna; Nursen Unlu; Hüseyin Üstün; Gültekin Köklü; Faruk Öztürk
PURPOSE To investigate effectiveness of doxycycline after trabeculectomy in rabbits by evaluating bleb appearance, intraocular pressure, and levels of matrix metalloproteinase-1, -2, -3, and -9 and tissue inhibitors of metalloproteinase (TIMP)-1 and -2 in the subconjunctival (sc) area. METHODS Twenty-nine New Zealand White rabbits were assigned into 1 of 6 groups as follows: topical doxycycline (0.1%), postoperative sc injection of doxycycline (100 mg/2 mL), and intraoperative mitomycin-C (MMC) (0.2 mg/mL) and their respective control groups. RESULTS There was significant difference between intraocular pressure in the case groups, but there was no significant difference in topical doxycycline and MMC groups during the follow up. In the topical doxycycline group, levels of TIMP-1 and perifericTIMP-1 were higher and levels of perifericMMP-2 and inflammation were lower than their controls. In the sc doxycycline group, peripheral inflammation was higher than in the corresponding control. Only peripheral inflammation was significantly different between case groups, with the highest level in sc and the lowest level in MMC groups. Further, topical doxycycline group showed no significant difference in bleb appearance or peripheral inflammation compared with MMC group. Conjunctival burn and corneal vascularization were detected only in the sc doxycycline group. CONCLUSIONS Topical doxycycline is more effective than sc doxycycline but is similar to MMC, and it can be an alternative to MMC in trabeculectomy in rabbits.
Journal of Glaucoma | 2012
Emine Sen; Dilek Berker; Ufuk Elgin; Yasemin Tutuncu; Faruk Öztürk; Serdar Guler
Purpose:To compare the optic nerve head topographic parameters of the cases with Graves disease (GD), and the age and sex-matched control group, by using Heidelberg retinal tomography III. Materials and Methods:We evaluated both eyes of 65 patients with GD and 54 age and sex-matched controls. For statistical analysis, Mann-Whitney U test and independent sample t test were used. Statistical significance was set as P<0.05. Results:The study group consisted of 22 male (33.8%) and 43 female (66.2%) GD cases with a mean age of 40.3±11.9 years and the control group consisted of 26 male (48.1%) and 28 female (51.9%) healthy controls with a mean age of 36.9±7.6 years. The differences between the age and sexes of the groups were not statistically significant (P=0.07 and P=0.11, respectively). The mean intraocular pressure of the study group was 14.6±2.9 mm Hg (range, 8 to 20 mm Hg), whereas in the control group, it was 13.4±2.1 mm Hg (range, 10 to 19 mm Hg). The difference between the intraocular pressures was statistically significant (P=0.01). The mean retinal nerve fiber layer (RNFL) thickness (0.31±0.08 mm) and the mean RNFL cross-sectional area (1.52 ±0.43 mm2) of the control group were greater than the mean RNFL thickness (0.25±0.06 mm) and the mean RNFL cross-sectional area (1.30±0.32 mm2) of the study group (P=0.02, P=0.03 respectively). Conclusions:This result suggests that patients with GD may have thinner RNFL than healthy controls.
Journal of Medical Case Reports | 2010
Ayse Altinok; Melike Balikoglu; Emine Sen; Kurtuluş Serdar
IntroductionCorneal damage associated with abuse of topical anesthetics is a rare clinic entity. Topical anesthetic abuse is one of the causes of ring keratitis. Ring keratitis is easily overlooked because it can mimic acanthamoeba keratitis or other infectious keratitis. The outcome is often poor, leading to persistent epithelial defects, corneal scarring, and perforations.Case presentationWe report the clinical presentation, diagnosis, and treatment of a 65-year-old Caucasian man, who worked as a health care worker, with bilateral toxic keratopathy caused by topical anesthetic abuse. Nonpreserved amniotic membrane transplantation was performed for both eyes of the patient.ConclusionIt is important to identify and treat patients who abuse topical anesthetics before permanent vision loss ensues. Nonpreserved amniotic membrane transplantation may be useful in relieving pain and improving corneal surface in anesthetic agent abusers.
European Journal of Ophthalmology | 2014
Pinar Nalcacioglu-Yuksekkaya; Emine Sen; Aşan Önder; Semra Çetinkaya; Tülay Tos; Ece Kurtul; Zehra Aycan
Purpose To evaluate central corneal thickness (CCT) values in patients with Turner syndrome (TS) and compare these values with healthy subjects. Methods A total of 31 subjects with TS and 67 age- and sex-matched healthy subjects made up the study and control group, respectively. The CCT values were measured by an ultrasound pachymeter in this cross-sectional prospective study. The ocular findings were recorded. We also evaluated to effect of karyotype analysis, recombinant growth hormone therapy (GHT), and mean duration of treatment on the CCT parameter in patients with TS. Results The mean CCT values were 582.0 ± 40.8 μm (490-648) in the TS and 549.1 ± 34.6 μm (494-601) in the healthy group. The mean intraocular pressure (IOP) by Goldmann applanation tonometry was 16.3 ± 3.1 mm Hg (9-22) in the TS and 15.2 ± 2.5 mm Hg (10-21) in the healthy group. The mean CCT value was significantly higher in the TS group (p<0.05) but there was no statistically significant difference between the 2 groups for IOP (p>0.05). There was also no significant difference for CCT regarding the karyotype, GHT use, and mean duration of treatment in patients with TS (p>0.05). Conclusions Central corneal thickness values should be considered during measurement of IOP in individuals with TS as these values may be higher than in healthy subjects.
Ophthalmologica | 2013
Mehmet Yasin Teke; Ufuk Elgin; Emine Sen; Pinar Ozdal; Faruk Öztürk
Purpose: To detect the early effects of pars plana vitrectomy (PPV) combined with intravitreal gas tamponade on corneal biomechanics and compare these effects of sulfur hexafluoride (SF<sub>6</sub>) and perfluropropane (C<sub>3</sub>F<sub>8</sub>). Methods: 19 eyes underwent PPV with C<sub>3</sub>F<sub>8</sub>, 14 eyes underwent PPV with SF<sub>6</sub> tamponade and 16 eyes underwent PPV without tamponade. Corneal biomechanical parameters were measured preoperatively and at the first postoperative week by an ocular response analyzer. Results: There were no significant differences of corneal hysteresis (CH), corneal resistance factor (CRF), corneal compensated intraocular pressure (IOPcc) and Goldmann-correlated intraocular pressure (IOPg) between the groups preoperatively. The mean CRF, IOPcc and IOPg significantly increased at the first postoperative week in the C<sub>3</sub>F<sub>8</sub> group. In the SF<sub>6</sub> group, CRF increased significantly but the increases in IOPcc and IOPg were not significant. In the PPV group, the increases in CRF, IOPcc and IOPg were not significant. The mean CH decreased in the C<sub>3</sub>F<sub>8</sub>, SF<sub>6</sub> and PPV groups postoperatively but these results were not significant. No statistically significant differences were found between the changes of preoperative and postoperative CH, CRF and IOPg between the groups, but the increase in IOPcc was statistically significantly higher in the C<sub>3</sub>F<sub>8</sub> group than the others. Conclusion: SF<sub>6</sub> and C<sub>3</sub>F<sub>8</sub> gas tamponade may affect corneal biomechanical parameters at the early postoperative period which should be related with surgery, gas tamponade or intraocular pressure changes.
International Journal of Ophthalmology | 2016
Esra Ergan; Faruk Öztürk; Emrullah Beyazyildiz; Ufuk Elgin; Emine Sen; Ali Bulent Cankaya; Tugrul Celik
AIM To evaluate total antioxidant status (TAS), total oxidant status (TOS), and the oxidative stress index (OSI) of the aqueous humor (AH) in patients with glaucoma. METHODS The prospective study was composed of a study group (n=31) and a control group (n=31). Fifteen patients in the study group were diagnosed with primary open angle glaucoma (POAG), and 16 patients were diagnosed with pseudoexfoliation glaucoma (PEG). The control group was composed of non-glaucomatous patients with cataracts. AH samples were collected and analyzed for TAS, TOS, and OSI levels. RESULTS Mean AH TAS level was significantly higher in patients with glaucoma than that in the control group (P<0.01). Mean TOS and OSI levels tended to increase in patients with glaucoma. No significant differences in TAS, TOS, or OSI levels were observed between patients with POAG and PEG. CONCLUSION High levels of TAS were observed in patients with glaucoma, which was likely a response to the increased oxidative stress observed in these patients.
International Journal of Ophthalmology | 2014
Pinar Nalcacioglu-Yuksekkaya; Emine Sen; Ufuk Elgin; Mumin Hocaoglu; Faruk Öztürk; Sebahat Yilmaz; Havva Nur Peltek Kendirci; Semra Çetinkaya; Zehra Aycan
AIM To compare the corneal parameters of children with congenital isolated growth hormone deficiency and healthy subjects. METHODS In this cross-sectional, prospective study, 50 cases with growth hormone (GH) deficiency treated with recombinant GH and 71 healthy children underwent a complete ophthalmic examination. The corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg) and corneal-compensated intraocular pressure (IOPcc) were measured with the Ocular Response Analyzer (ORA). Central corneal thickness (CCT) was measured by a ultrasonic pachymeter. RESULTS The mean age was 13.0±3.0 years in the GH deficiency group consisting of 21 females and 29 males and 13.4±2.4 years in the healthy children group consisting of 41 females and 30 males. There was no statistically significant difference between the groups for gender or age (Chi-square test, P=0.09; independent t-test, P=0.28, respectively). The mean duration of recombinant GH therapy was 3.8±2.4y in the study group. The mean CH, CRF, IOPg and IOPcc values were 11.0±2.0, 10.9±1.9, 15.1±3.3, and 15.1±3.2 mm Hg respectively in the study group. The same values were 10.7±1.7, 10.5±1.7, 15.2±3.3, and 15.3±3.4 mm Hg respectively in the control group. The mean CCT values were 555.7±40.6, 545.1±32.5 µm in the study and control groups respectively. There was no statistically significant difference between the two groups for CH, CRF, IOPg, IOPcc measurements or CCT values (independent t-test, P=0.315, 0.286, 0.145, 0.747, 0.13 respectively). CONCLUSION Our study suggests that GH deficiency does not have an effect on the corneal parameters and CCT values. This observation could be because of the duration between the beginning of disease and the diagnosis and beginning of GH therapy.
Indian Journal of Ophthalmology | 2014
Emine Sen; Yasemin Tutuncu; Ufuk Elgin; Melike Balikoglu-Yilmaz; Dilek Berker; F. Nur Aksakal; Faruk Öztürk; Serdar Guler
Aims: The aim was to compare the intraocular pressure (IOP), central corneal thickness (CCT), and optic disc topography findings of biochemically controlled acromegalic patients and the control group and to evaluate the effect of the duration of acromegaly and serum growth hormone and insulin-like growth factor-1 (IGF-1) levels on these ocular parameters. Materials and Methods: IOP measurement with Goldmann applanation tonometry, CCT measurement with ultrasonic pachymetry, and topographic analysis with Heidelberg retinal tomograph III were performed on 35 biochemically controlled acromegalic patients and 36 age- and gender-matched controls. Results: Mean IOP and CCT were 14.7 ± 2.9 mmHg and 559.5 ± 44.9 μm in the acromegaly patients and 13.0 ± 1.6 mmHg and 547.1 ± 26.7 μm in controls (P = 0.006 and P = 0.15, respectively). A significant moderate correlation was found between the duration of acromegaly and CCT (r = 0.391) and IOP (r = 0.367). Mean retinal nerve fiber layer (RNFL) thickness was significantly lower in the acromegalic patients (0.25 ± 0.05 mm) as compared to controls (0.31 ± 0.09 mm) (P = 0.01). A significant moderate correlation was detected between IGF-1 level and disc area (r = 0.362), cup area (r = 0.389) and cup volume (r = 0.491). Conclusion: Biochemically controlled acromegalic patients showed significantly higher CCT and IOP levels and lower RNFL thickness compared to healthy controls and the duration of disease was correlated with CCT and IOP levels.