Emine Şen

Age-related changes in biomechanical parameters of the cornea and intraocular pressure in a healthy Turkish population.

BACKGROUND/AIM To investigate age-related changes in intraocular pressure (IOP) and biomechanical parameters of the cornea in healthy subjects. MATERIALS AND METHODS There were 404 healthy subjects included prospectively in this study. The subjects were divided into 3 groups (Group 1:93 subjects aged < 18, Group 2:189 subjects aged between 18 and 59, and Group 3:122 subjects aged ≥ 60). Corneal compensated IOP (IOPCC), Goldmann correlated IOP (IOPg), corneal hysteresis (CH), and corneal resistance factor (CRF) were measured by the Ocular Response Analyzer. RESULTS When all the study groups were evaluated, a moderately significant negative correlation was found between age and CH and between age and CRF (Spearmans rho = -0.372 and -0.353, respectively; P < 0.0001 for both correlations). There were significant age-related differences among the 3 groups in terms of IOPg, CH, CRF, and central corneal thickness (P = 0.002, P = 0.000, P = 0.000, P = 0.006). There was no confirmation of any difference of IOPcc among the groups (P = 0.427). CONCLUSION The mean values of IOPg, CH, and CRF were lower than the other parameters in Group 3 but no significant differences were determined in IOPcc values in the age groups.

The effect of trabeculectomy on serum brain-derived neurotrophic factor levels in primary open-angle glaucoma

PurposeWe aimed to investigate the effect of trabeculectomy on serum brain-derived neurotrophic factor (BDNF) levels. Our secondary goal was to compare serum and aqueous humor (AH) BDNF levels in primary open-angle glaucoma (POAG) and control subjects.MethodsThis prospective, cross-sectional study consists of 20 eyes of with advanced-stage POAG who had trabeculectomy and 19 eyes of age- and sex-matched control healthy subjects who had cataract surgery. Serum and AH samples were obtained preoperatively in trabeculectomy group and control subjects. Serum samples were obtained at the third postoperative month in both groups.ResultsThe aqueous humor and serum levels of BDNF at the surgery day were found to be strongly positive correlated (r = 0.868; p < 0.001). Serum and AH BDNF levels of POAG cases were significantly lower than control subjects at the surgery day (respectively p = 0.038, p = 0.011). In POAG cases, serum BDNF levels significantly increased at the third month after trabeculectomy while there was not a significant difference in control subjects with cataract surgery (p < 0.001; p = 0.717 respectively).ConclusionTrabeculectomy was found to have a positive effect on serum BDNF levels in POAG cases.

Early Postoperative Effects of Cataract Surgery on Anterior Segment Parameters in Primary Open-Angle Glaucoma and Pseudoexfoliation Glaucoma.

Objectives: To compare the effect of cataract surgery on anterior segment parameters measured by optical biometry in primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG). Materials and Methods: Twenty-five eyes of 25 patients with POAG and 29 eyes of 29 patients with PXG who had uncomplicated phacoemulsification and posterior chamber intraocular lens implantation surgery were included to our prospective study. Central corneal thickness (CCT), anterior chamber depth (ACD) and axial length (AL) were measured with an optical biometer preoperatively and at 1 month postoperatively. The pre- and postoperative values of intraocular pressure (IOP) and the anterior segment parameters and the differences between POAG and PXG were compared statistically by paired t, independent t and chi-square tests. Results: The mean values of preoperative CCT (p=0.042) and ACD (p=0.012) were significantly lower in the PXG than in the POAG group. In the PXG group, IOP decreased (p=0.001) but CCT (p=0.03) and ACD (p=0.001) increased significantly postoperatively; AL did not change significantly. In the POAG group, IOP decreased (p=0.01) and ACD (p=0.004) increased significantly postoperatively, while AL and CCT did not change significantly. There were no significant differences in the pre- to postoperative changes in IOP (p=0.76), AL (p=0.44) and CCT (p=0.52) values between the two groups. However, the postoperative increase in ACD was larger in the PXG group (p=0.03). Conclusion: Cataract surgery may cause some changes in IOP and anterior segment parameters like ACD and CCT postoperatively in eyes with POAG and PXG, and these changes may differ between eyes with PXG and POAG.

A Comparison of Optic Disc Topographic Parameters in Primary Open-Angle Glaucoma Cases with or without Family History of Glaucomai

Amaç: Aile hikayesi olan ve olmayan primer aç›k aç›l› glokom (PAAG) olgular›n›n tan› esnas›ndaki optik disk topografik de¤erlerinin k›yaslanmas›. Gereç ve Yöntem: Aile hikayesi olan (26 hasta, 52 göz) ve olmayan (28 hasta, 56 göz) PAAG olgular›, geriye dönük olarak incelendi. Tüm hastalar›n düzeltilmifl görme keskinli¤i, biyomikroskopik, fundus ve gonyoskopik muayeneleri, Goldmann aplanasyon tonometresi ile göziçi bas›nc› (G‹B) de¤erleri, Heidelberg Retinal Tomografi (HRT) III ile optik disk topografi analizleri, Humphrey otomatize perimetri ile görme alan› incelemeleri ve ultrasonik pakimetri ile merkezi kornea kal›nl›k (MKK) de¤erleri kaydedildi. ‹statistiksel yöntem olarak Mann-Whitney U testi, ki kare ve t test kullan›ld›. Sonuçlar: Ailesinde glokom hikayesi pozitif olan grup ile olmayan grup aras›nda; yafl, cinsiyet, MKK, G‹B, HRT III parametreleri aç›s›ndan fark saptanmad›. Tan› esnas›ndaki yafl ortalamas› aile hikayesi pozitif olan grupta 48,1±8,6, olmayan grupta ise 56,4±10,9 idi. Aile hikayesi olan olgularda yafl anlaml› olarak daha genç bulundu (p:0,003). Tart›flma: Aile hikayesi olan ve olmayan PAAG hastalar›nda tan› esnas›nda optik disk topografik parametreleri aras›nda fark tesbit edilmemifltir. Ancak aile hikayesi olan PAAG olgular›nda daha erken yaflta tan› konuldu¤u gözlenmifltir. (TOD Dergisi 2010; 40: 205-8) Anahtar Kelimeler: Aile hikayesi, Heidelberg retinal tomografi, optik disk topografisi, primer aç›k aç›l› glokom