Emine Türkmen

Prevention of renal ischemia/reperfusion-induced injury in rats by leflunomide

Objective: There is increasing evidence to suggest that toxic oxygen radicals play an essential role in the pathogenesis of ischemia/reperfusion (I/R) injury in the kidney. This study was designed to investigate the effects of leflunomide, an isoxazole derivative and a unique immunomodulatory agent, in I/R‐induced renal injury in rats.

Attenuation of ureteral obstruction‐induced renal injury by polyenylphosphatidylcholine

Background:  The cytoprotective, antioxidant and antifibrotic effects of polyenylphosphatidylcholine (lecithin, PPC) have been demonstrated both experimentally and clinically. The present study investigated whether PPC treatment has any beneficial effect on renal injury in unilateral partial ureteral obstruction (UUO) in rats.

Spindle cell lipoma in an intramuscular lipoma

Intramuscular lipoma (IML) is a relatively common variant of lipomas. The most important sites for IML are the large muscles of the extremities. Spindle cell lipoma (SCL) is a rare and distinct variant of lipoma. Most SCL arise in the neck, shoulders or back. It has also been described in unusual sites, such as the oral cavity, larynx, bronchus, breast, orbit and extremities. However, localization of a SCL in an IML has not been described yet. Thus, we present the first SCL located in an IML, which was localized underneath the fascia and embedded within the left sartorius muscle of a 55‐year‐old man. Microscopically, the SCL component of the tumor was sharply circumscribed by a fibrous capsule and clearly seperated from the IML in which it was localized. The collagen‐forming spindle cells of the SCL showed neither atypia nor pleomorphism. These cells stained positive for CD34, while the mature fat tissue component of the SCL was positive for S‐100 protein and negative for CD34. Spindle cells were negative for S‐100 protein. Vimentin stained both components of the SCL, as well as the striated muscle fibers and mature fat tissue of the IML. In conclusion, careful morphological observation along with immunohistochemistry for CD34 and S‐100 protein are essential to differentiate this rare tumor from lesions that enter the differential diagnosis.

Role of Matrix Metalloproteinase-7 in Colorectal Adenomas

Matrix metalloproteinases (MMPs) degregade and remodel the extracellular matrix. They are known to be overexpressed as normal mucosa progresses to adenomas and carcinomas. In our prospective study we measured the overexpression of MMP-7 immunohistochemically in various types of colonic adenomas. Although MMP-7 has already been shown to be overexpressed in various types of colonic adenomas, tubular versus villous adenomas had not been further seperated to date. Seventy-six patients had either normal mucosa (n=15) or tubular (n=32), tubulovillous (n=16), or villous (n=13) colonic adenoma. MMP-7 expression was classified into three categories, as negative, weakly stained, or strongly stained, depending on the percentage of cells stained. Each adenoma was graded according to the percentage of strongly stained areas in the adenoma as G0, G1, G2, or G3. Sixty-nine percent of villous adenomas showed grade 3 staining of MMP-7, versus none of the tubular adenomas. G0 and G1 staining was not detected in the villous adenomas. The results of the study show that the degrees of overexpression of the three subtypes of colonic adenomas were statistically significantly different. In conclusion, MMP-7 overexpression is thought to be an early event in the adenoma-carcinoma pathway.

Polyenylphosphatidylcholine pretreatment ameliorates ischemic acute renal injury in rats

Aim:  Polyenylphosphatidycholine has been demonstrated to have antioxidant, cytoprotective and anti‐inflammatory effects. Whether polyenylphosphatidycholine pretreatment affects ischemia/reperfusion‐induced renal damage in vivo is not known and was investigated here in rats.

A Newborn with Massive Congenital Astroblastoma

1Department of Pathology, Inonu University School of Medicine, Malatya, Turkey; 2Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas; 3Department of Radiology, Inonu University School of Medicine, Malatya, Turkey; 4Department of Pediatrics, Inonu University School of Medicine, Malatya, Turkey; 5Division of Neonatology, Department of Pediatrics, Inonu University School of Medicine, Malatya, Turkey

Two cases of severe familial ochronotic arthropathy

Ochronotic spondylarthropathy, a long-term musculoskeletal manifestation of alkaptonuria and involvement of joints may lead to a radiographic appearance similar to that of degenerative joint disease. We report the cases of two siblings with progressive familial ochronotic arthropaty treated with total hip arthroplasty.RésuméLa spondylarthropathie de l’ochronose, une manifestation musculo-squelettique à long terme d’alcaptonurie se traduit par des images radiologiques articulaires simulant une arthrose dégénérative. Nous rapportons ici deux cas d’enfants de mêmes parents, souffrant d’arthropathie ochronotique familiale progressive, traités par arthroplastie totale de hanches.