Emre Ergul

Bilateral paget disease of the male nipple: First report

Bilateral breast carcinoma is reported to occur in 5-10% of all patients with breast cancer. Paget disease of the breast represents 1-3% of all breast malignancies [Ashikari R, Park K, Huvos AG, Urban JA. Pagets disease of the breast. Cancer 1970;26:680-5; Marshall JK, Griffith KA, Haffty BG, Solin LJ, Vicini FA, McCormick B, et al. Conservative management of Paget disease of the breast with radiotherapy. Cancer 2003;97:2142-9]. However, synchronous bilateral Paget disease of the nipple is extremely rare. We report synchronous bilateral Paget disease with infiltrative ductal carcinoma in a 74-year-old man who underwent bilateral mastectomy.

Glomus tumor of the breast: first report.

Glomic tumors are uncommon, painful, and usually benign hamartomas which often found on the fingertips. They arise from the normal glomus apparatus, located in the subcutaneous tissue. A glomus body is composed of an afferent arteriole, an anastomotic Suquet-Hoyer canal, an efferent venule, actin-containing glomus cells surrounding the canals, the intraglomerular reticulum, and a capsular portion [1]. The normal glomus body is a contractile neuromyoarterial receptor that controls blood pressure and temperature by regulating peripheral blood flow. Glomus bodies are present in the stratum reticularis of the dermis throughout the body. So, glomus tumors can occur in many parts of the body. We did not come across any case of glomus tumor at breast during our review of literature. Also, Bisceglia et al reported, at their review, that no glomus tumor either sporadic or in the context of any immunodeficiency has been recorded at breast [2]. Here, we present the first case.

Does low molecular weight heparin impair anastomotic wound healing

BackgroundEnoxaparin is an important molecule which had been using in prophylaxis and treatment of deep venous thrombosis. Also, it is showed that it prevents postsurgical peritoneal adhesions in rats. It is aimed to evaluate its effects on gastrointestinal wound healing.MethodsThirty Wistar albino rats were divided into three groups as control, subcutan, and intraperitoneal enoxaparin groups. Left colon anastomoses were performed. On postoperative seventh day, anastomotic healing was evaluated by measuring anastomotic bursting pressure, tissue hydroxyproline levels, and histopathological examination.ResultsThe anastomotic bursting pressure was highest in subcutan enoxaparin group (p < 0.001), intraperitoneal enoxaparin group (p < 0.01) came the second, and the control group has the worst value. The hydroxyproline results were found nearly similar to the bursting pressure values (subcutan (p < 0.001) > intraperitoneal (p < 0.05) > control). Neovascularization in subcutan group (p < 0.001) has a statistically significant difference to other groups.ConclusionEnoxaparin did not interfere with colonic anastomotic resistance but improved the intestinal wound healing.

Castleman's disease of the duodenum: a case report.

Castleman’s disease, or angiofollicular lymphoid hyperplasia, or angiomatous lymphoid hamartoma is a rare lymphoproliferative disorder of uncertain origin, which was first described in 1956 (1). The pathologic characteristic of this disease is hyperplasia of the lymph follicle, multiple blood vessel penetration and infiltration of plasma cells in the interfollicular area. In 1972, KELLER et al. (2) named this disease Castleman’s disease and divided it into two types : hyaline vascular (HV) type and plasma cell (PC) type, a classification that is still used at present. To our knowledge, only two cases of Castleman’s disease of the gastro-intestinal tract have been reported. These two cases were found in the stomach (3, 4). However, as far as we know, Castleman’s disease of the duodenum has not been reported. We report a rare form of this disease with a literature review.