Enid C. Rodaniche

The use of sulfaguanidine in non-specific ulcerative colitis and other infections of the bowel

1. Sulfaguanidine, while not as readily absorbed from the intestine as other sulfonamides, is, nevertheless, absorbed to some extent. When doses of 10 to 15 grams are given daily, the blood levels may reach 10 mg. %. 2. Although reactions may occur during its administration, sulfaguanidine appears to be less toxic than other commonly used sulfonamides. 3. Sulfaguanidine, in doses of 10 to 15 grams daily, usually decreases the bacterial count of the feces markedly and transforms the flora from one predominantly coliform in type to one composed almost entirely of gram positive organisms. 4. Sulfaguanidine is of no value in the treatment of Paratyphoid B infection. It apparently has no advantage over other sulfonamides in the treatment of lymphogranuloma venereum. The long continued use of sulfaguanidine in chronic, non specific ulcerative colitis has not yielded any striking therapeutic results.