Enid T. Oppenheimer

Sarcomas Induced in Rats by Implanting Cellophane

Conclusions 1. Sarcomas were induced in albino fats by the insertion of regenerated cellulose film either subcutaneously or by wrapping it around one kidney. 2. These tumors occurred in about 35% of the rats surviving the operation more than 11 months. 3. The tumors were transplantable. 4. This is a simple method for inducing sarcomas experimentally. 5. The foregoing results in rats should be taken into consideration in the surgical use of cellophane in man.

Oral Administration of Penicillin.

A convenient, practical and effective procedure of administering penicillin by mouth consists of mixing the drug with one tablespoonful of aluminum hydroxide. Substantially higher blood levels are obtained following a 50,000 and a 100,000 unit dose of penicillin with this method than after administration of the drug dissolved in water, either with or without previous ingestion of a mild antacid, such as aluminum hydroxide. Adsorption of penicillin on aluminum hydroxide appears to exert a local protective effect against that portion of gastric acid with which it comes into contact.